Rb-associated protein 46 (RbAp46) suppresses the tumorigenicity of adenovirus-transformed human embryonic kidney 293 cells

International Journal of Cancer

Volumn 93, Issue 3, 2001, Pages 333-338

  Guan, Li Shuang ^a   Li, Guan Cheng ^a   Chen, Cui Cai ^a   Liu, Li Qing ^a   Wang, Zhao Yi ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; G2 M phase; RbAp46; Tumor suppressor

Indexed keywords

GENE PRODUCT; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA SUPPRESSOR ASSOCIATED PROTEIN 46; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENICITY; CELL CYCLE; CELL GROWTH; CELL LINE; CONTROLLED STUDY; CORRELATION FUNCTION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOVIRIDAE; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARRIER PROTEINS; CELL CYCLE; CELL LINE; CELL TRANSFORMATION, VIRAL; DNA FRAGMENTATION; EMBRYO; GENE EXPRESSION; HUMANS; KIDNEY NEOPLASMS; MICE; NUCLEAR PROTEINS; RETINOBLASTOMA; TUMOR STEM CELL ASSAY;

EID: 0035427119     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1338     Document Type: Article

References (28)

1. A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product
2. A retinoblastoma-binding protein with properties related to a negative regulator of Ras in yeast
3. Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast
4. The ancient regulatory-protein family of WD-repeat proteins
5. A conserved family of WD-40 proteins binds to the retinoblastoma protein in both plants and animals
6. Msil, a negative regulator of the Ras-cAMP pathway in Saccharomyces cerevisiae
7. Lin-35 and Lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
8. Histone deacetylase and SAP18, a novel polypeptide, are components of a human Sin3 complex
9. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein
10. The LAZ3 (BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression
11. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
12. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
13. Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition
14. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
15. WT1-mediated growth suppression of Wilms' tumor cells expressing a WT1 splicing variant
16. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis
17. The tumor suppressor gene WT1 inhibits ras-mediated transformation
18. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
19. Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cells
20. Cyclin D3 sensitizes tumor cells to tumor necrosis factor-induced, c-Myc-dependent apoptosis
21. Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E
22. Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells
23. Induction of apoptosis in fibroblasts by c-myc protein
24. Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha
25. Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF
26. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
27. A role of cyclin G in the process of apoptosis
28. The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice