Physiological modulation of rabphilin phosphorylation

Journal of Neuroscience

Volumn 21, Issue 15, 2001, Pages 5473-5483

  Foletti, Davide L ^a   Blitzer, Jeremy T ^a   Scheller, Richard H ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

Author keywords

Brain acute slices; Phosphospecific antibodies; Protein kinases; Rab3a; Rabphilin; Synaptic transmission

Indexed keywords

RAB PROTEIN; RABPHILIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; MOUSE; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION;

EID: 0035426142     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-15-05473.2001     Document Type: Article

References (38)

1. The stimulatory effect of rabphilin 3a on regulated exocytosis from insulin-secreting cells does not require an association-dissociation cycle with membranes mediated by Rab 3
2. A genomic perspective on membrane compartment organization
3. Rabphilin-3A: A multifunctional regulator of synaptic vesicle traffic
4. Evidence that the Rab3a-binding protein, rabphilin3a, enhances regulated secretion. Studies in adrenal chromaffin cells
5. Importance of the Rab3a-GTP binding domain for the intracellular stability and function of Rabphilin3a in secretion
6. 2+- dependent manner. In vitro characteristics and possible significance
7. A small GTP-binding protein dissociates from synaptic vesicles during exocytosis
8. Depolarization of cerebellar granule cells increases phosphorylation of rabphilin-3A
9. 2+/calmodulin- and cAMP-dependent protein kinases in vitro
10. The role of Rab3a in neurotransmitter release
11. Synaptic vesicle phosphoproteins and regulation of synaptic function
12. A phospho-switch controls the dynamic association of synapsins with synaptic vesicles
13. Membrane fusion and exocytosis
14. High affinity Rab3 binding is dispensable for Rabphilin-dependent potentiation of stimulated secretion
15. Phosphorylation of Rabphilin-3A by calmodulin-dependent protein kinase II
16. Physical and functional interaction of rabphilin-3A with alpha-actinin
17. 2+-dependent exocytosis from PC12 cells
18. 2+/phospholipid-binding protein, depends on rab3A/3C
19. Mechanisms of synaptic vesicle exocytosis
20. Region-specific phosphorylation of rabphilin in mossy fiber nerve terminals of the hippocampus
21. Whole-cell voltage-clamp techniques applied to the study of synaptic function in hippocampal slices
22. Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs
23. Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus
24. 2+ and phosphatidylserine
25. Role of the Rab3A-binding domain in targeting of rabphilin-3A to vesicle membranes of PC12 cells
26. Phosphorylation of Rabphilin-3A, a putative target protein for Rab3A, by cyclic AMP-dependent protein kinase
27. Involvement of Rabphilin3 in endocytosis through interaction with Rabaptin5
28. 2+ and phospholipid
29. Structural basis of Rab effector specificity: Crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A
30. Rabphilin knock-out mice reveal that rabphilin is not required for rah3 function in regulating neurotransmitter release
31. Rabphilin-3A is associated with synaptic vesicles through a vesicle protein in a manner independent of Rab3A
32. GTP cleavage by the small GTP-binding protein Rab3A is associated with exocytosis of synaptic vesicles induced by alpha-latrotoxin
33. Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras
34. Protein phosphorylation and the regulation of synaptic membrane traffic
35. Structure of the Janus-faced C2B domain of rabphilin
36. Two pharmacologically and kinetically distinct transient potassium currents in cultured embryonic mouse hippocampal neurons
37. Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains