C1 inhibitor: Analysis of the role of amino acid residues within the reactive center loop in target protease recognition

Journal of Immunology

Volumn 167, Issue 3, 2001, Pages 1500-1506

  Zahedi, R ^a   MacFarlane, R C ^a   Wisnieski, J J ^a   Davis III, A E ^a  

^a CENTER FOR BLOOD RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BLOOD CLOTTING FACTOR 12A; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C1S INHIBITOR; GLUTAMINE; KALLIKREIN; MUTANT PROTEIN; PLASMIN; SERINE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; THREONINE; THROMBIN; TRYPSIN; VALINE;

AMINO ACID SUBSTITUTION; ANGIONEUROTIC EDEMA; ANIMAL CELL; ARTICLE; CELL STRAIN COS1; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME INHIBITOR INTERACTION; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DENATURATION; SITE DIRECTED MUTAGENESIS;

EID: 0035424141     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.3.1500     Document Type: Article

References (47)

1. Some properties of an esterase derived from preparations of the first component of complement
2. Inhibition by C1-INH of Hageman factor fragment activation of coagulation, fibrinolysis, and kinin generation
3. The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C1′r subcomponent of complement by serum C1′ esterase inhibitor
4. Interaction of plasma kallikrein with the C1 inhibitor
5. Inhibition of activated Hageman factor and activated plasma thromboplastin antecedent by purified C1 inactivator
6. Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: Major role for C1-inhibitor
7. Serpins: The superfamily of serine proteinase inhibitors
8. Mechanism of serpin action: Evidence that C1 inhibitor functions as a suicide substrate
9. Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family: Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes
10. Human α1-proteinase inhibitor: Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function
11. Structure of a serpin-protease complex shows inhibition by deformation
12. The structure of a serpin-proteinase complex revealed by intramolecular distance measurements using donor-donor energy migration and mapping of interaction sites
13. Structural basis for serpin inhibitor activity
14. Major proteinase movement upon stable serpin-proteinase complex formation
15. 359) of α-1-proteinase inhibitor
16. Mutation of antitrypsin to antithrombin
17. Reactivity of α1-antitrypsin mutants against proteolytic enzymes of the kallikrein-kinin, complement and fibrinolytic systems
18. Role of the P2 residue in determining the specificity of serpins
19. Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils
20. Site-directed mutagenesis of the reactive center (serine 394) of antithrombin III
21. Combinatorial mutagenesis of the reactive site region in plasminogen activator inhibitor
22. Protein engineering of chimeric serpins: An investigation into effects of the serpin scaffold and reactive centre loop length
23. The P6-P2 region of serpins is critical for proteinase inhibition and complex stability
24. Influence of the P5 residue on α1-proteinase inhibitor mechanism
25. 443-Val substitution and functional analysis of the recombinant mutant protein
26. 443) in determination of target protease specificity
27. Molecular defects in hereditary angioneurotic edema
28. 387-Val) causing recurrent venous thrombosis
29. 436Thr) results in nonsubstrate-like behavior and in polymerization of the molecule
30. Human C1 inhibitor: Improved isolation and preliminary structural characterization
31. Ovalbumin and angiotensinogen lack serpin S-R conformational change
32. Kinetics of the reaction between human C1-esterase inhibitor and C1r or C1s
33. Kinetics of interaction of C1 inhibitor with complement C1s
34. Kinetics of reaction of human C1-inhibitor with the human complement system proteases C1r and C1s
35. Functional analysis of the serpin domain of C1 inhibitor
36. Characterization of C1 inhibitor-Ta: A dysfunctional C1 inhibitor with deletion of lysine-251
37. Mutagenesis of recombinant protein C inhibitor reactive site residues alters target proteinase specificity
38. Site-directed mutagenesis of the P2 residue of human antithrombin
39. Crystal structure of the catalytic domain of human complement C1s: A serine protease with a handle
40. Comparison of structures of various human fibrinogens and a derivative thereof by a study of the kinetics of release of fibrinopeptides
41. Thrombin specificity: Requirement for apolar amino acids adjacent to the thrombin cleavage site for polypeptide substrate
42. Hereditary angioneurotic edema: Characterization of plasma kinin and vascular permeability-enhancing activities
43. Plasma bradykinin in angio-oedema
44. Epitope mapping of C1 inhibitor autoantibodies from patients with acquired C1 inhibitor deficiency
45. A secondary C1s interaction site on C1-inhibitor is essential for formation of a stable enzyme-inhibitor complex
46. Role of the distal hinge region of C1-inhibitor in the regulation of C1s activity
47. C1 inhibitor cross-linking by tissue transglutaminase