Improvement of the synthesis of diphenylmethyl 7β-(o-hydroxy)benzylideneamino-3-hydroxymethyl-3-cephem-4-carboxylate

Farmaco

Volumn 56, Issue 8, 2001, Pages 629-631

  López, Miguel ^a   Rodríguez, Zalua ^a   Valdés, Bárbara ^a   Velez, Hermán ^a   Agüero, Juan ^a   Fini, Adamo ^b   González, Maritza ^b  

^a Centro de Quimica Farmaceutica   (Cuba)

^b Istituto di Scienze Chimiche   (Italy)

Author keywords

Diphenyldiazomethane; p Toluenesulfonamide; Purification

Indexed keywords

7 AMINOCEPHALOSPORANIC ACID; BENZOPHENONE HYDRAZONE; CARBOXYLIC ACID DERIVATIVE; DIAZOMETHANE; DIPHENYLDIAZOMETHANE; DIPHENYLMETHYL 7BETA (4 HYDROXY)BENZYLIDENEAMINO 3 HYDROXYMETHYL 3 CEPHEM 4 CARBOXYLATE; HYDRAZONE DERIVATIVE; TOLUENESULFONAMIDE DERIVATIVE; TOSYLCHLORAMIDE SODIUM; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL REACTION; DRUG PURIFICATION; DRUG PURITY; DRUG SYNTHESIS; TECHNIQUE;

BENZENE; BENZENE DERIVATIVES; BENZHYDRYL COMPOUNDS;

EID: 0035424095     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01115-6     Document Type: Article

References (5)

1. 3-Phosphonium and 3-phosphoranylidene-cephems
2. Studies on β-lactam antibiotics, IX: Synthesis and biological activity of new orally active Cephalosporin, Cefixime (FK0207)
3. Amino-acids and peptides. Part II. A new method for preparing diazodiphenylmethane and related compounds