DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules

Nucleic Acids Research

Volumn 29, Issue 15, 2001, Pages 3241-3247

  Stefanovsky, Victor Y ^a   Pelletier, Guillaume ^a   Bazett Jones, David P ^b   Crane Robinson, Colyn ^c   Moss, Tom ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CURVED DNA; DNA; DNA DIRECTED RNA POLYMERASE; DOUBLE STRANDED DNA; ENHANCESOME; HIGH MOBILITY GROUP PROTEIN; HOMEODOMAIN PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; DNA CONTENT; DNA DETERMINATION; DNA FLANKING REGION; DNA STRUCTURE; ENHANCER REGION; GENE DELETION; GENE INSERTION; GENE MUTATION; MOLECULAR MODEL; NONHUMAN; NUCLEOSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RIBOSOME; STRUCTURE ANALYSIS; XENOPUS;

EID: 0035419327     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.15.3241     Document Type: Article

References (32)

1. Recognition of the Xenopus ribosomal core promoter by the transcription factor xUBF involves multiple HMG box domains and leads to an xUBF interdomain interaction
2. Short-range DNA looping by the Xenopus HMG-box transcription factor, xUBF
3. The DNA supercoiling architecture induced by the transcription factor xUBF requires three of its five HMG-boxes
4. Promotion and regulation of ribosomal transcription in eukaryotes by RNA Polymerase I
5. The structural and architectural role of Upstream Binding Factor, UBF
6. The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor
7. Phosphorylation of the rRNA transcription factor upstream binding factor promotes its association with TATA binding protein
8. Dimerization and HMG box domains 1-3 present in Xenopus UBF are sufficient for its role in transcriptional enhancement
9. Recruitment of TATA-binding protein-TAF complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation
10. xUBF contains a novel dimerization domain essential for RNA polymerase I transcription
11. Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription
12. Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription
13. Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF
14. xUBF, an RNA polymerase I transcription factor, binds crossover DNA with low sequence specificity
15. HMG box proteins bind to four-way DNA junctions in their open conformation
16. The structure of the four-way junction in DNA
17. Protein expression
18. The RNA polymerase I transcription factor xUBF contains 5 tandemly repeated HMG homology boxes
19. More ribosomal spacer sequences from Xenopus laevis
20. A complex array of sequences enhances ribosomal transcription in Xenopus laevis
21. Empirical basis for phosphorous mapping and structure determination of DNA:protein complexes by electron spectroscopic imaging
22. Electron microscopy shows that TFIIIA bends DNA
23. Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific binding
24. DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1
25. Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product
26. Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein
27. The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation
28. Differential phosphorylation and localisation of the transcription factor UBF in vivo in response to serum deprivation
29. Analysis of the phosphorylation, DNA-binding and dimerization properties of the RNA polymerase I transcription factors UBF1 and UBF2
30. HMG box 4 is the principal determinant of species specificity in the RNA polymerase I transcription factor UBF
31. The DNA bend angle and binding affinity of an HMG box increased by the presence of short terminal arms
32. The structure of a chromosomal high mobility group protein-DNA complex reveals sequence-neutral mechanisms important for non-sequence-specific DNA recognition