Cytotoxicity and effect on collagen biosynthesis of proline analogue of melphalan as a prolidase-convertible prodrug in cultured human skin fibroblasts

Farmaco

Volumn 56, Issue 9, 2001, Pages 701-706

  Chrzanowski, Krzysztof ^a   Bielawska, Anna ^a   Bielawski, Krzysztof ^a   Wolczyński, Slawomir ^a   Palka, Jerzy ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Collagen; Human skin fibroblasts; Prodrug; Prolidase; Proline analogue of melphalan

Indexed keywords

MELPHALAN; PRODRUG;

ARTICLE; CELL VIABILITY; CHROMATOGRAPHY; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS, ALKYLATING; CELL SURVIVAL; CELLS, CULTURED; CHILD; COLLAGEN; DIPEPTIDASES; FIBROBLASTS; HUMANS; MALE; MELPHALAN; PRODRUGS; PROLINE; SKIN;

EID: 0035415880     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01130-2     Document Type: Article

References (18)

1. Metabolism and reactions of alkylating agents
2. Disposition and tumor localization of mitomycin C-dextran conjugates in mice
3. Development of a novel polymeric prodrug of mitomycin C-dextran conjugate with anionic charge. II. Disposition and pharmacokinetics following intravenous and intramuscular administration
4. Utilization of peptide carrier system to improve intestinal absorption: targeting prolidase as a prodrug-converting enzyme
5. Prolidase as a prodrug converting enzyme. III. Synthesis of proline analogue of melphalan and their susceptibility to the action of prolidase
6. Primary structure and gene localization of human prolidase
7. Disorders of proline and hydroxyproline metabolism
8. Iminopeptiduria. A genetic defect in recycling collagen: a method for determining prolidase in red blood cells
9. Scorbutic and fasted guinea pig sera contain an insulin-like growth factor-I reversible inhibitor of proteoglycan and collagen synthesis in chick embryo chondrocytes and adult human skin fibroblasts
10. Determination of collagen synthesis in tissue and cell culture system
11. Optimal conditions for prolidase assay by proline colorimetric determination: application to imidodipeptiduria
12. Photometric estimation of proline and ornithine
13. Protein measurement with the Folin phenol reagent
14. Evaluation of a tetrazolinum-based semiautomated colorimetric assay: assessment of chemosensitivity testing
15. Studies on the transport and cellular distribution of chlorambucil in the Yoshida ascites sarcoma
16. Uptake and decomposition of chlorambucil by L5178Y lymphoblasts in vitro
17. 1 integrin expression in moderately and poorly differentiated lung adenocarcinomas
18. Collagen metabolism disturbances are accompanied by an increase in prolidase activity in lung carcinoma planoepitheliale