IL-1β is essential for langerhans cell activation and antigen delivery to the lymph nodes during contact sensitization: Evidence for a dermal source of IL-1β

Cellular Immunology

Volumn 211, Issue 2, 2001, Pages 105-112

  Shornick, Laurie P ^a   Bisarya, Alvin K ^a   Chaplin, David D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; Cytokine; Dendritic cell; Interleukin 1 ; Langerhans cell; Skin

Indexed keywords

ANTIGEN; CHLOROBENZENE; FLUORESCEIN ISOTHIOCYANATE; HAPTEN; MESSENGER RNA; RECOMBINANT INTERLEUKIN 1BETA; HLA ANTIGEN CLASS 2; INTERLEUKIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW CELL; CELL ACTIVATION; CONTACT ALLERGY; CONTACT SENSITIZATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; LANGERHANS CELL; LYMPH NODE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKIN CELL; ANIMAL; C57BL MOUSE; CELL TRANSPLANTATION; CYTOLOGY; DERMIS; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; MOUSE MUTANT; SKIN; STAINING;

ANIMALS; ANTIGEN PRESENTATION; BONE MARROW CELLS; CELL TRANSPLANTATION; DERMIS; GENE EXPRESSION; HAPTENS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOPHENOTYPING; INTERLEUKIN-1; LANGERHANS CELLS; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SKIN; STAINING AND LABELING;

EID: 0035413238     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2001.1834     Document Type: Article

References (34)

1. Phenotypic and functional characteristics of in vivo-activated Langerhans cells
2. An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin
3. Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ
4. Langerhans cells produce type IV collagenase (MMP-9) following epicutaneous stimulation with haptens
5. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer flourescein isothiocyanate
6. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization
7. Functional dichotomy between Langerhans cells that present antigen to naive and to memory/effector T lymphocytes
8. Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone
9. + murine epidermal Langerhans cells are deficient in surface expression of the class I major histocompatibility complex
10. Absence of lymph nodes in lymphotoxin-α (LT-α)-deficient mice is due to abnormal organ development, not defective lymphocyte migration
11. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
12. Early molecular events in the induction phase of contact sensitivity
13. Epidermal Langerhans cells are derived from cells originating in the bone marrow
14. Occurrence of donor Langerhans cells in mouse and rat chimeras and their replacement in skin grafts
15. Role of cytokines in epidermal Langerhans cell migration
16. Langerhans cells require signals from both tumour necrosis factor-alpha and interleukin-1 beta for migration
17. Effects of contact allergens on human Langerhans cells in skin organ culture: Migration, modulation of cell surface molecules, and early expression of interleukin-1 beta protein
18. Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: Augmentation by TNF-alpha and IL-1beta
19. Interleukin 1 is present in normal human epidermis
20. The presence of epidermal-derived thymocyte activating factor/interleukin 1 in normal human stratum corneum
21. Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1
22. Activated human Langerhans cells express mRNA for IL-1 alpha and IL-1 beta and produce these cytokines but do not secrete them
23. Synthesis of interleukin-1α and β by normal human melanocytes
24. Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures
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26. Interleukin-1 beta converting enzyme in murine Langerhans cells and epidermal-derived dendritic cell lines
27. T cell-dependent secretion of IL-1 beta by a dendritic cell line (XS52) derived from murine epidermis
28. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro
29. Migration of dendritic cells into lymphatics - The Langerhans cell example: Routes, regulation, and relevance
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31. Cutaneous dermal Ia+ cells are capable of initiating delayed type hypersensitivity responses
32. Human dermal dendritic cells process and present soluble protein antigens
33. Characterization of epidermal cytokine profiles in sensitization and elicitation phases of allergic contact dermatitis as well as irritant contact dermatitis in mouse skin