Epitope mapping on Wegener's granulomatosis autoantigen proteinase 3

Chinese Medical Journal

Volumn 114, Issue 7, 2001, Pages 760-763

  Huang, Zhen ^a   Lockwood, Christopher Martin ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Anti neutrophil cytoplasmic autoantibodies; Epitope; Proteinase 3; Vasculitis; Wegener's granulomatosis

Indexed keywords

AUTOANTIGEN; MONOCLONAL ANTIBODY; MYELOBLASTIN; SERINE PROTEINASE;

ANIMAL; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HUMAN; IMMUNOLOGY; MOUSE; WEGENER GRANULOMATOSIS; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIGENS; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HUMANS; MICE; MYELOBLASTIN; SERINE ENDOPEPTIDASES; WEGENER GRANULOMATOSIS;

EID: 0035411877     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Hoffman GS, Specks U. Antineutrophil cytoplasmic antibodies. Arthritis Rheum 1998;41:1521-1537.
2. Huang Z, Zhao MH, Lockwood CM. Epitope mapping on the proteinase 3 molecule using monoclonal antibodies and sera from patients with Wegener's granulomatosis. Clin Exp Immunol 1995; 101:50-51.
3. Zhao MH, Lockwood CM. A comprehensive method to purify three major ANCA antigens: proteinase 3, myeloperoxidase and bactericidal/permeability-increasing protein from human neutrophil granule acid extract. J Immunol Methods 1996;197:121-130.
4. Zhao MH, Jones SJ, Lockwood CM. Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasm autoantibodies (ANCA) in vasculitis. Clin Exp Immunol 1995;99:49-56.
5. Bini P, Gabay JE, Teitel A, et al. Antineutrophil cytoplasmic autoantibodies in Wegener's granulomatosis recognize conformational epitope(s) on proteinase 3. J Immunol 1992; 149: 1409-1415.
6. Williams RC, Staud R, Malone CC, et al. Epitopes on proteinase 3 recognized by abtibodies from patients with Wegener's granulomatosis. J Immunol 1994;152:4722-4737.
7. Chang L, Binos S, Savige J. Epitope mapping of anti-proteinase 3 and anti-myeloperoxidase antibodies. Clin Exp Immunol 1995;102: 112-119.
8. Sommarin Y, Rasmussen N, Wieslander J. Characterization of monoclonal antibodies to proteinase 3 and application in the study of epitopes for classic anti-neutrophil cytoplasm antibodies. Exp Nephrol 1995;3:249-256.