Purification of saponin compounds in Bupleurum falcatum by solvent partitioning and preparative LC

Bioscience, Biotechnology and Biochemistry

Volumn 65, Issue 7, 2001, Pages 1648-1651

  Kim, Namsoo ^a   Park, In Seon ^a  

^a Korea Food Research Institute   (South Korea)

Author keywords

Preparative LC; Purification; Saikosaponins; Solvent partitioning

Indexed keywords

BUPLEURUM; BUPLEURUM FALCATUM;

DRUG DERIVATIVE; OLEANOLIC ACID; SAIKOSAPONIN; SAPOGENIN; SAPONIN; SOLVENT;

ARTICLE; BUPLEURUM; CHEMICAL STRUCTURE; CHEMISTRY; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY;

BUPLEURUM; CHROMATOGRAPHY, LIQUID; MOLECULAR STRUCTURE; OLEANOLIC ACID; SAPOGENINS; SAPONINS; SOLVENTS;

EID: 0035409611     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.65.1648     Document Type: Article

References (13)

1. Shibata, S., Kitagawa, I., and Fujimoto, H., The structure of saikogenin A, a sapogenin of Bupleurum species. Tetrahedron Letters, 42, 3783-3788 (1965).
2. Kubota, T. and Tonami, F., Triterpenoids from Bupleurum falcatum L.-II. Isolation of saikogenin B and longispinogenin. Tetrahedron, 23, 3353-3362 (1967).
3. Ishii, H., Seo, S., Tori, K., Tozyo, T., and Yoshimura, Y., The structures of saikosaponin-E and acetylsaikosaponins, minor components isolated from Bupleurum falcatum L. determined by C-13 NMR spectroscopy. Tetrahedron Letters, 14, 1227-1230 (1977).
4. Yen, M. H., Lin, C. C., and Yen, C. M., The immunomodulatory effect of saikosaponin derivatives and the root extract of Bupleurum kaoi in mice. PTR,-Phytother-res., 9, 351-358 (1995).
5. Park, Y.-H., Song, M.-J., and Kim, N., Studies on platelet activation of saikosaponin isolated from Bupleuri Radix. J. Food Hyg. Safety, 13, 355-359 (1998).
6. Kimata, H., Hiyama, C., Yahara, S., Tanaka, O., Ishikawa, O., and Aiura, M., Application of high performance liquid chromatography to the analysis of crude drugs: Separatory determination of saponins of Bupleuri Radix. Chem. Pharm. Bull., 27, 1836-1841 (1979).
7. Nose, M., Amagaya, S., Takeda, T., and Ogihara, Y., New derivatives of saikosaponin C. Chem. Pharm. Bull., 37, 1293-1296 (1989).
8. 1. Chem. Pharm. Bull., 39, 1250-1252 (1991).
9. Ishii, H., Nakamura, M., Seo, S., Tori, K., and Tozyo, T., Characterization and nuclear magnetic response spectra of new saponins from the roots of Bupleurum falcatum L. Chem. Pharm. Bull., 28, 2367-2373 (1980).
10. 18 fatty acid, a lignan, and a new chromone. Chem. Pharm. Bull., 38, 3169-3171 (1990).
11. Park, I.-S., Kang, E. M., and Kim, N., High performance liquid chromatographic analysis of saponin compounds in Bupleurum falcatum. J. Chromatogr. Sci., 38, 229-233 (2000).
12. Chapman, L., Johns, T., and Mahunnah, R. L. A., Saponin-like in vitro characteristics of extracts from selected non-nutrient wild plant food additives used by Maasai in meat and milk based soups. Ecol. Food Nutrit., 36, 1-22 (1997).
13. Kimata, H., Sumida, N., Matsufuji, N., Orita, T., Ito, K., Yata, N., and Tanaka, O., Interaction of saponin of Bupleuri radix with ginseng saponin: solubilization of saikosaponin-a with chikusetsu saponin V (= ginsenoside-Ro). Chem. Pharm. Bull., 33, 2849-2853 (1985).