Antiretroviral-induced hepatic steatosis and lactic acidosis: Case report and review of the literature

American Surgeon

Volumn 67, Issue 7, 2001, Pages 680-683

  Ellozy, Sharif ^a   Massen, Richard ^a   Chao, Lynn ^c   Divino, Celia M ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DIDANOSINE;

ACUTE ABDOMEN; ADULT; ARTICLE; CASE REPORT; CHEMICALLY INDUCED DISORDER; DIFFERENTIAL DIAGNOSIS; FATTY LIVER; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LACTIC ACIDOSIS; LIVER; LIVER FAILURE; PATHOLOGY; ABDOMEN, ACUTE; ACIDOSIS, LACTIC; CHEMICALLY INDUCED; HIV INFECTIONS;

ABDOMEN, ACUTE; ACIDOSIS, LACTIC; ADULT; ANTI-HIV AGENTS; DIAGNOSIS, DIFFERENTIAL; DIDANOSINE; FATTY LIVER; FEMALE; HIV INFECTIONS; HUMANS; LIVER; LIVER FAILURE;

EID: 0035405602     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Bissuel F, Bruneel F, Habersetzer F, et al. Fulminant hepatitis with severe lactic acidosis in HIV-infected patients on didanosine therapy (case report). J Intern Med 1994;235:367-72.
2. Lai KK, Gang DL, Zawacki JK, Cooley TP. Fulminant hepatic failure associated with 2′,3′-dideoxyinosine (ddl). Ann Intern Med 1991;115:283-4.
3. Sundar K, Suarez M, Banogon P, Shapiro J. Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: Report of two patients and review of the literature. Crit Care Med 1997;25:1425-30.
4. Freimann JP, Helfert KE, Hamrell MR, Stein DS. Hepatomegaly with severe steatosis in HIV-seropositive patients. AIDS 1993;7:379-85.
5. Olano JP, Borucki MJ, Wen JW. Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine. Clin Infect Dis 1995;21:973-6.
6. Fortgang IS, Belitsos PC, Chaisson RE, Moore RD. Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy. Am J Gastroenterol 1995;90:1433-6.
7. Hu B, French S. 2′,3′-Dideoxyinosine-induced Mallory bodies in patients with HIV. Am J Clin Pathol 1997;- 108:280-3.
8. Lewis W, Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nat Med 1995;1:417-22.
9. Tsai CH, Doong SL, Johns DG, et al. Effects of anti-HIV 2′-β-fluoro-2′3′-dideoxynucleoside analogues on the cellular content of mitochondrial DNA and on lactate production. Biochem Pharmacol 1994;48:1477-81.
10. Medina DJ, Tsai CH, Hsiung GD, Cheng YC. Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides. Antimicrob Agents Chemother 1994;38:1824-8.