A comparative study of cellular and molecular pharmacology of doxorubicin and MEN 10755, a disaccharide analogue

Biochemical Pharmacology

Volumn 62, Issue 1, 2001, Pages 63-70

  Bigioni, Mario ^a   Salvatore, Carmela ^a   Bullo, Angela ^a   Bellarosa, Daniela ^a   Iafrate, Elisabetta ^a   Animati, Fabio ^a   Capranico, Giovanni ^b   Goso, Cristina ^a   Maggi, Carlo Alberto ^a   Pratesi, Graziella ^c   Zunino, Franco ^c   Manzini, Stefano ^a  

^a Menarini Ricerche SpA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Anthracycline disaccharides; Apoptosis; DNA breaks; DNA topoisomerase; Doxorubicin; Drug uptake

Indexed keywords

ADENINE; ANTHRACYCLINE; CARBOHYDRATE DERIVATIVE; DISACCHARIDE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; SABARUBICIN; UNCLASSIFIED DRUG; [7 O [2,6 DIDEOXY 4 O (2,3,6 TRIDEOXY 3 AMINO ALPHA LEVO LYXO HEXOPYRANOSYL)ALPHA LEVO LYXO HEXOPYRANOSYL (4 DEMETHOXY 14 HYDROXY DAUNOMYCINONE)]];

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DNA DAMAGE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXPOSURE; DRUG MECHANISM; DRUG POTENCY; DRUG UPTAKE; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; MITOSIS; OVARY CARCINOMA; PRIORITY JOURNAL;

EID: 0035400724     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00645-1     Document Type: Article

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