Implications of selective type II IMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death

Biochemical Pharmacology

Volumn 62, Issue 1, 2001, Pages 91-100

  Barnes, Betsy J ^a   Eakin, Ann E ^a,b   Izydore, Robert A ^c   Hall, Iris H ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

1,5 Diazabicyclo 3.1.0 hexane 2,4 diones; Antineoplastic chemotherapy; Type II IMP dehydrogenase

Indexed keywords

6 ETHOXYCARBONYL 3 ETHYL 3 (4 METHYLPHENYL) 1,5 DIAZABICYCLO[3.1.0]HEXANE 2,4 DIONE; 6 ETHOXYCARBONYL 3 ETHYL 3 PHENYL 1,5 DIAZABICYCLO[3.1.0]HEXANE 2,4 DIONE; 6 ETHOXYCARBONYL 3,3 DIETHYL 1,5 DIAZABICYCLO[3.1.0]HEXANE 2,4 DIONE; CARBONYL DERIVATIVE; INOSINATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CELL LINE; CELL METABOLISM; CHEMICAL STRUCTURE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; TUMOR CELL;

BICYCLO COMPOUNDS, HETEROCYCLIC; CELL DIVISION; DRUG INTERACTIONS; ENZYME INHIBITORS; GUANOSINE; HELA CELLS; HL-60 CELLS; HUMANS; IMP DEHYDROGENASE; TUMOR CELLS, CULTURED;

EID: 0035400551     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00649-9     Document Type: Article

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