X-ray induction of microsatellite instability at autosomal loci in human lymphoblastoid WTK1 cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 478, Issue 1-2, 2001, Pages 97-106

  Romney, Carla A ^a   Paulauskis, Joseph D ^a   Little, John B ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Genomic instability; Human lymphoblastoid cell; Microsatellite repeats

Indexed keywords

MICROSATELLITE DNA; THYMIDINE KINASE;

ARTICLE; AUTOSOME; CELL CLONE; CHROMOSOME 16Q; CONTROLLED STUDY; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; MICROSATELLITE INSTABILITY; MUTATION RATE; PRIORITY JOURNAL; RADIATION EXPOSURE; X RAY;

CELL LINE; CHROMOSOMES, HUMAN, PAIR 16; DNA; DNA MUTATIONAL ANALYSIS; HUMANS; LYMPHOCYTES; MICROSATELLITE REPEATS; MUTAGENESIS; MUTAGENICITY TESTS; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; THYMIDINE KINASE; X-RAYS;

EID: 0035400488     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00126-9     Document Type: Article

References (38)

1. A new theory on the cancer inducing mechanism
2. The age distribution of cancer and a multistage theory of carcinogenesis
3. A two-stage theory of carcinogenesis in relation to the age distribution of human cancer
4. Mutation and cancer: Statistical study of retinoblastoma
5. A genetic model for colorectal tumorigenesis
6. How many mutations are required for tumorigenesis? Implications from human cancer data
7. Analysis of cancer incidence data on the basis of multistage and clonal growth models
8. The clonal evolution of tumor cell populations
9. Mutator phenotype may be required for multistage carcinogenesis
10. Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor
11. Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus
12. Human lymphoblast lines from lymph node and spleen
13. Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation
14. Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines
15. Abrogation of p53 function by HPV16 E6 delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells
16. + mammalian cells
17. Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates
18. A simple salting out procedure for extracting DNA from human nucleated cells
19. Genetic instability on chromosome 16 in a human B lymphoblastoid cell line
20. The 1993-94 Genethon human genetic linkage map
21. Isolation and chromosomal arrangement of 100 highly informative human simple sequence repeat polymorphisms
22. Dinucleotide repeat polymorphism at D16S287
23. Unusual variability of the complex dinucleotide repeat block at the SPN locus
24. Isolation and characterisation of (AC)n microsatellite genetic markers from human chromosome 16
25. Dinucleotide repeat polymorphisms at D16S260, D16S261, D16S265, D16S266, and D16S267 loci
26. A second-generation linkage map of the human genome
27. The polymerase chain reaction: An improved method for the analysis of nucleic acids
28. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
29. Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations
30. Cancer of the microsatellite mutator phenotype
31. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
32. p53 functions as a cell cycle control protein in osteosarcomas
33. Multiple dispersed spontaneous mutations: A novel pathway of mutation in a malignant human cell line
34. Mutations of transforming growth factor beta I type II receptor, BAX, and insulin-like growth factor II receptor genes in microsatellite unstable cell lines
35. Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status
36. The CEPH consortium linkage map of human chromosome 16