Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-γ production in human peripheral blood mononuclear and NK cells

Journal of Immunology

Volumn 167, Issue 1, 2001, Pages 497-504

  Lee, S J ^a   Cho, Y S ^a   Cho, M C ^a   Shim, J H ^a   Lee, K A ^a   Ko, K K ^a   Yong Kyung Choe, ^a   Park, S N ^a   Hoshino, T ^a   Kim, S H ^a   Dinarello, C A ^a   Yoon, D Y ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 18; ONCOPROTEIN; VIRUS PROTEIN;

ALPHA CHAIN; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL SURFACE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR FLUID; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERFERON PRODUCTION; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR BLOCKING; REGULATORY MECHANISM; UTERINE CERVIX CARCINOMA; VIRUS PATHOGENESIS; WART VIRUS;

EID: 0035399616     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.1.497     Document Type: Article

References (59)

1. Papillomavims infections: A major cause of human cancers
2. Prevalence of human papillomavirus in cervical cancer: A worldwide perspective
3. Human papillomavirus and invasive cervical cancer in Brazil
4. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
5. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
6. ras to immortalize primary mouse cells
7. Human papillomavirus type 16 gene expression and DNA replication in cervical neoplasia: Analysis by in situ hybridization
8. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
9. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
10. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
11. Comparison of the in vitro transforming activities of human papillomavirus types
12. Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma
13. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein
14. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation
15. Functions of human papillomavirus proteins
16. Analysis of the interaction between human papillomavirus type 16 E7 and the TATA-binding protein, TBP
17. The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors
18. Orthopoxvirus IL-18 binding proteins: Affinities and antagonist activities
19. Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response
20. IL-18 binding and inhibition of interferon γ induction by human poxvirus-encoded proteins
21. Interleukin-18
22. Cloning of a new cytokine that induces IFN-γ, production by T cells
23. A poxvirus protein with a RING zinc finger motif is of crucial importance for virulence
24. Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins
25. In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection
26. Interteukin-18 protects mice against acute herpes simplex virus type 1 infection
27. Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy
28. Convergent infections: Human papillomavirus and human immunodeficiency virus
29. Human papillomavirus type 16 E7 oncoprotein expressed in peripheral epithelium tolerizes E7-directed cytotoxic T-lymphocyte precursors restricted through human (and mouse) major histocompatibitity complex class I alleles
30. Antibodies against early proteins of human papillomaviruses as diagnostic markers for invasive cervical cancer
31. Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer derived cell line and identification of the E7 protein
32. Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis
33. Cytokine production patterns in cervical intraepithelial neoplasia: Association with human papillomavirus infection
34. Comparative lymphokine secretion by cultured normal human cervical keratinocytes, papillomavirus-immortalized, and carcinoma cell lines
35. Production of neutralizing monoclonal anti-hIL-18 antibodies and their applications
36. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
37. Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines
38. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ
39. Characterization of a subclone (DIOS) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens
40. Antibodies to domains II and III of the IL-1 receptor accessory protein inhibit IL-1 activity but not binding: Regulation of IL-1 responses is via type I receptor, not the accessory protein
41. Development of screening systems for drugs against human papillomavirus-associated cervical cancer: Based on E6-E6AP binding
42. Development of screening system for drugs against human papillomavirus-associated cervical cancer: Based on E7-Rb binding
43. Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products
44. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
45. A dot-immunobinding assay for monoclonal and other antibodies
46. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells
47. Inflammatory response in cervical intraepithelial neoplasia and squamous cell carcinoma of the uterine cervix
48. The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours
49. Leukoregulin and γ-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells
50. E7-specific cytotoxic T cell tolerance in HPV-transgenic mice
51. Antibodies to human papillomavirus and to other genital infectious agents and invasive cervical cancer risk
52. Antibodies to HPV-16 E6 and E7 proteins as markers for HPV-16-associated invasive cervical cancer
53. Induction of cellular immunosuppression by the human papillomavirus type 16 E7 oncogenic protein
54. HPV-16 E7 but not E6 oncogenic protein triggers both cellular immunosuppression and angiogenic processes
55. The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha
56. Interleukin 18-interferon γ inducing factor: A novel player in tumour immunotherapy?
57. Virus infection activates IL-1β and IL-18 production in human macrophages by a caspase-1-dependent pathway
58. The E3L gene of vaccinia virus encodes and inhibitor of the interferon-induced, double stranded RNA-dependent protein kinase
59. Repression of the interferon signal transduction pathway by the adenovirus E1A oncogene