Synthesis and evaluation of the analgesic and antiinflammatory activities of O-substituted salicylamides

Archives of Pharmacal Research

Volumn 24, Issue 3, 2001, Pages 171-179

  Fahmy, H H ^a   El Eraky, W ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Analgesic and antiinflammatory activities; O substituted salicylamides; Oxadiazole; Pyrazol; Pyrazolone; Thiadiazole

Indexed keywords

ANALGESIC AGENT; CARRAGEENAN; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; NONSTEROID ANTIINFLAMMATORY AGENT; SALICYLAMIDE DERIVATIVE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; EDEMA; ELECTROSTIMULATION; MALE; PATHOLOGY; PLEURISY; RAT; STOMACH ULCER; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; EDEMA; ELECTRIC STIMULATION; INDICATORS AND REAGENTS; MALE; PLEURISY; RATS; SALICYLAMIDES; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035375930     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02978252     Document Type: Review

References (17)

1. Abbas, S. E., El-Ansary, S. L., and Mikhael, A. N., Synthesis of Some 1,3,4-Oxadiazolines and Thiazolidinones of Expected Antibacterial Activity. Egypt. J. Pharm. Sci., 35, 21-30 (1994).
2. Abdel-Motti, F. M., Alafaleg, E. I., and Almehbad, N. Y. F., Synthesis and Reaction of Some Derivatives of Pyridazinylthioglycolic Acid Hydrazide with Possible Antimicrobial Activity. ibid, 36, 117-124 (1995).
3. Charlier, R., M. Prost, F. Binon, and G. Deltour, Pharmacology of an Anti-tussive-1-Phenyl-2-propynyl-4-propinoxypiperidine acid Fumarate. Arch. Intern. Pharamacodyn., 134, 306 (1961).
4. Coleman, D. L., Wood, N. L., and Darling, W. M. Martindale the Extrapharmacopoei Edited by James E. E. Reynolds Published by Direction of The Council of Royal Pharmaceutical Society of Great Britain. Thirtieth Edition, 1-36 (1993).
5. Corell, T., Moller, J. K., and Splawinskim, J., A New Antiinflammatory Derivative of Indiazole Which Is Less Ulcerogenic than Indomethacin in Rats. Acta Pharmacol., er. Toxicol., 45, 232-239 (1979).
6. Daidone, G., Raffa, D., and Piescia, S., Synthesis and Evaluation of the Analgesic and Antiinflammatory Activities of N-Substituted Salicylamides, IL. Farmaco 44 (5), 465-473 (1989).
7. El-sebai, A. I., Rida, S. M., Beltagy, Y. A., and Abdel-Khalek, M. M. Synthesis of Some New Semisynthetic Penicillins. Pharmazie, 29 (9), 581 (1974).
8. Fahmy, H. H., Synthesis of Some New Quinoline Derivatives of Potential Antimicrobial Activity. Egypt. J. Pharm. Sci., 38, 403-414 (1997).
9. Fahmy, H. H., W. Abdou, A. M., and El-eraky, W., Synthesis of some new pyrazolones as potent antiinflammatory agent. Bull. Fac. Pharm. Cairo Univ., 33, 85-92 (1995).
10. Fathalla, O. A., E. Kassem, M. M., Farouk, A., Synthesis of Some New Oxadiazoles and Thiazoles of Quinoline Derivatives as Antimicrobial Agents, Proceedings of the First International Scientific Conference (Science & Development), Fac. of Science Al-Azhar University, Cairo, 20-23 March, 101-112 (1995).
11. Furniss, B. S., Hannaford, A. N., Smith, P. W. G., and Tachel, A. R., Vogels Text Book of Practical Organic Chemistry, edited by Longmann, Singapore Publishers, Singapore, Pte Ltd. 716 (1989).
12. Kassem, E. M. M. and El-Masry, A., Synthesis of Some New Benzothiazole-2-Acrylic Acid Hydrazide Derivatives of Possible Biological Activity, Proceedings of the First International Scientific Conference (Science & Development), Fac. of Science Al-Azhar University, Cairo, 20-23 March, 114-134 (1995).
13. Kassem, E. M. M., El-difrawy, S., Fathalla, O. A., El-Ansary A., and Abdou, W. A. M., Synthesis of Some New Thiazolidinone Amide and Pyrazolidinones of Possible Inhibitory Effect on Biomphalaria Alexandrina Snail Enzymatic Activities. Egypt. J. Bilh., 15, 171-181 (1993).
14. Kumar, R. and Giri, S., Nizamuddin, Synthesis of Some 1-[5′-(Substituted-Phenoxymethyl)-1′,3′,4′-Thiadiazol- 2′-yl]-4-Substituted-2-azetidinones as Potential Fungicides. J. Indian Chem. Soc., LXV, 571-573 (1998).
15. Snedecol, W. G. and Cochran, G. W., Statistical Methods, Iowa State University, press, Ames., Iowa State. Ames., (1971).
16. Velo, G. P., Dunn, C. T., Giroud, J. P., Timisit, J., and Willoughby, D. A., Distribution of Prostaglandin in Inflammatory Exudate. J. Path., 111, 149 (1973).
17. Winter, C. A., Risley, E. A., and Nuss, G. W., Carrageenan Induced Oedema in Hind Paw of the Rat as an Assay for Antiinflammatory Drug. Proc. Soc. Exp. Biol. Med., 111, 544-547 (1962).