Chromosome stability, DNA recombination and the BRCA2 tumour suppressor

Current Opinion in Cell Biology

Volumn 13, Issue 3, 2001, Pages 338-343

  Venkitaraman, A R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DNA; DOUBLE STRANDED DNA;

CANCER INHIBITION; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL TRANSFORMATION; CHROMOSOME BREAKAGE; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; GENETIC STABILITY; HUMAN; MITOSIS; MODEL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION;

EID: 0035371286     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00217-9     Document Type: Review

References (42)

1. The genetics of breast cancer susceptibility
2. Internal repeats in the BRCA2 protein sequence
3. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2
4. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
5. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
6. Involvement of Brca2 in DNA repair
7. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
8. Brca2 is required for embryonic cellular proliferation in the mouse
9. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
10. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
11. The breast cancer susceptibility gene, BRCA2: At the crossroads between DNA replication and recombination?
12. Recombinational crossroads: Eukaryotic enzymes and the limits of bacterial precedents
13. Initiation of genetic recombination and recombination-dependent replication
14. Replication fork pausing and recombination or 'gimme a break'
15. The importance of repairing stalled replication forks
16. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation
17. BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo
18. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
19. BRCA2 is required for homology directed repair of chromosomal breaks
20. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
21. Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations
22. Requirement of ATM dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks
23. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
24. In search of the tumour-suppressor functions of BRCA1 and BRCA2
25. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
26. DNA double-strand breaks caused by replication arrest
27. RuvAB acts at arrested replication forks
28. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
29. Mitotic checkpoint inactivation fosters the transformation of cells lacking the breast cancer susceptibility gene BRCA2
30. Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1
31. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression
32. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
33. BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
34. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
35. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
36. Sequencespecific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1
37. BRCA2 associates with acetyltransferase activity when bound to P/CAF
38. The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase
39. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells
40. Insights into the functions of BRCA1 and BRCA2
41. Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol