Proteolysis of von Willebrand factor is increased during cardiopulmonary bypass

Thrombosis Research

Volumn 102, Issue 5, 2001, Pages 467-473

  Perutelli, Paolo ^a  

^a G GASLINI INSTITUTE   (Italy)

Author keywords

Cardiopulmonary bypass; Cardiovascular surgery; Extracorporeal circulation; Multimeric analysis; von Willebrand factor

Indexed keywords

LEUKOCYTE ENZYME; PROTEIN SUBUNIT; PROTEINASE; VON WILLEBRAND FACTOR;

ADOLESCENT; ADULT; ARTICLE; BLEEDING DISORDER; CARDIOPULMONARY BYPASS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MOLECULAR WEIGHT; PLASMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN STRUCTURE; SHEAR STRESS; SUBENDOTHELIUM; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOSIS; TUBE; VON WILLEBRAND DISEASE;

ADOLESCENT; ADULT; BLOTTING, WESTERN; CARDIOPULMONARY BYPASS; CHILD; CHILD, PRESCHOOL; COATED MATERIALS, BIOCOMPATIBLE; DIMERIZATION; FEMALE; HEPARIN; HUMANS; MALE; PEPTIDE HYDROLASES; PROTEIN SUBUNITS; VON WILLEBRAND FACTOR;

EID: 0035370566     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(01)00272-9     Document Type: Article

References (22)

1. Von Willebrand factor: Biological function and molecular defects
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3. Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit
4. Two-dimensional analysis of the structure of human von Willebrand factor
5. Abnormalities of plasma von Willebrand factor multimeric structure induced by extracorporeal circulation
6. A rapid and sensitive method for the analysis of von Willebrand factor multimeric structure
7. Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma
8. Subunit composition of plasma von Willebrand factor
9. Binding of von Willebrand factor to glycoproteins Ib and IIb-IIIa complex: Affinity is related to multimeric size
10. Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets
11. Shear stress enhances the proteolysis of von Willebrand factor in normal plasma
12. Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion
13. Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis
14. Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type IIA von Willebrand disease from those generated by plasmin
15. Blood contact activation: Pathophysiological effects and therapeutic approaches
16. Inflammatory response to cardiopulmonary bypass
17. Endothelial cell-derived high molecular weight von Willebrand factor is converted into the plasma multimer pattern by granulocyte proteases
18. Proteolysis of subendothelial adhesive glycoproteins (fibronectin, thrombospondin, and von Willebrand factor) by plasmin, leukocyte cathepsin G, and elastase
19. Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass
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21. Complement activation during extracorporeal circulation. In vitro comparison of Duraflo II heparin-coated and uncoated oxygenator circuits
22. Complement consumption during cardiopulmonary bypass: Comparison of Duraflo II heparin-coated and uncoated circuits in fully heparinized patients