RANTES production from CD4+ lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression

Journal of Infectious Diseases

Volumn 183, Issue 11, 2001, Pages 1678-1681

  Paxton, William A ^a   Neumann, Avidan U ^b   Kang, Stanley ^a   Deutch, Lisa ^b   Brown, R Clark ^c   Koup, Richard A ^d   Wolinsky, Steven M ^c  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b BAR ILAN UNIVERSITY   (Israel)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; RANTES; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; GENE EXPRESSION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS REPLICATION;

ALLELES; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; DISEASE PROGRESSION; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MALE; RANTES; RECEPTORS, CCR5; RECEPTORS, HIV; RNA, MESSENGER; RNA, VIRAL; VIRAL LOAD;

EID: 0035370258     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/320701     Document Type: Article

References (14)

1. Unutmaz D, Kewal Ramani VN, Littman DR. G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models. Semin Immunol 1998; 10:225-36.
2. Paxton WA, Kang S. Chemokine receptor allelic polymorphisms: relationships to HIV resistance and disease progression. Semin Immunol 1998; 10:187-94.
3. Michael NL, Chang G, Louis LG, et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med 1997; 3:338-40.
4. Michael NL. Host genetic influences on HIV-1 pathogenesis. Curr Opin Immunol 1999; 11:466-74.
5. - lymphocytes from exposed, uninfected individuals: association with low expression of CCR5 and high production of β-chemokines. Virology 1998; 244:66-73.
6. Wu L, Paxton WA, Kassam N, et al. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1 in vitro. J Exp Med 1997; 185:1681-91.
7. Zagury D, Lachgar A, Chams V, et al. C-C chemokines, pivotal in protection against HIV type 1 infection. Proc Natl Acad Sci USA 1998; 95:3857-61.
8. +, T-cell clones correlates with the clinical state of human immunodeficiency virus type 1 (HIV-1)-infected individuals and may be responsible for blocking infection with non-syncytium-inducing HIV-1 in vitro. J Virol 1998; 72:876-81.
9. Gordon CJ, Muesing MA, Proudfoot AE, Power CA, Moore JP, Trkola A. Enhancement of human immunodeficiency virus type 1 infection by the CC-chemokine RANTES is independent of the mechanism of virus-cell fusion. J Virol 1999; 73:684-94.
10. Polo S, Veglia F, Malnati MS, et al. Longitudinal analysis of serum chemokine levels in the course of HIV-1 infection. AIDS 1999; 13:447-54.
11. Zhang L, He T, Huang Y, et al. Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1. J Virol 1998; 72: 9307-12.
12. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381:667-73.
13. + T cell responses associated with control of viremia. Science 1997; 278: 1447-50.
14. Ferbas J, Giorgi JV, Amini S, et al. Antigen-specific production of RANTES, macrophage inflammatory protein (MIP)-1α, and MIP-1β in vitro is a correlate of reduced human immunodeficiency virus burden in vivo. J Infect Dis 2000; 182:1247-50.