Nitric oxide enhances MPP+-induced hydroxyl radical generation via depolarization activated nitric oxide synthase in rat striatum

Brain Research

Volumn 902, Issue 2, 2001, Pages 223-228

  Obata, Toshio ^a   Yamanaka, Yasumitsu ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Depolarization, 1 Methyl 4 phenylpyridinium ion; Hydroxyl radical; MPP+; Nitric oxide synthase; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 2,3 DIHYDROXYBENZOIC ACID; ALLOPURINOL; DOPAMINE; FERROUS ION; HYDROXYL RADICAL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHLORIDE; POTASSIUM ION; RINGER SOLUTION; SALICYLATE SODIUM; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DEPOLARIZATION; DOSE RESPONSE; DRUG EFFECT; DRUG INFUSION; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ALLOPURINOL; ANIMALS; DOPAMINE; ENZYME INHIBITORS; EXTRACELLULAR SPACE; HERBICIDES; HYDROXYBENZOIC ACIDS; HYDROXYL RADICAL; IRON; IRON CHELATING AGENTS; MALE; MEMBRANE POTENTIALS; MICRODIALYSIS; NEOSTRIATUM; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PARKINSON DISEASE; POTASSIUM; RATS; RATS, WISTAR;

EID: 0035370071     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02203-X     Document Type: Article

References (27)

1. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
2. Brain microdialysis
3. In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia
4. Aorta and skeletal muscle NO synthase expression in experimental heart failure
5. Nitric oxide and oxygen radicals: A question of balance
6. Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products
7. In vivo autoxidation of dopamine in guinea pig striatum increases with age
8. Altered brain metabolism of iron as a cause of neurodegenerative diseases?
9. Hydroxylation of salicylate as an assay for hydroxyl radicals: A cautionary note
10. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
11. Importance of endogenous angiotensin II in the cardiovascular responses to sympathetic stimulation in conscious rabbits
12. +): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra
13. Role of conversion of xanthine dehydrogenase to oxidase in ischemic rat liver cell injury
14. Dopamine-derived 1-methyl-6,7-dihydroxy-isoquinolines as hydroxyl radical promoters and scavengers in the rat brain: In vivo and in vitro studies
15. Oxygen-derived free radicals in postischemic tissue injury
16. +
17. Reserpine prevents hydroxyl radical formation by MPP+ in rat striatum
18. 2+ channels involving depolarization-stimulated nitric oxide synthase activity in primary neuronal culture
19. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
20. ESR spin trapping investigation on peroxynitrite decomposition: No evidence for hydroxyl radical production
21. Mitochondrial toxins in models of neurodegenerative diseases. I: In vivo brain hydroxyl radical production drug systemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions
22. +
23. Inhibition of depolarization-induced nitric oxide synthase activation by NS-7, a phenylpyrimidine derivative, in primary neuronal culture
24. Myocardial protection by R 56865: A new principle based on prevention of ion channel pathology
25. Nitric oxide synthase in cardiac sarcoplasmic reticulum
26. Enzyme-independent formation of nitric oxide in biological tissues