Pressure- and heat-induced inactivation of butyrylcholinesterase: Evidence for multiple intermediates and the remnant inactivation process

Biochemical Journal

Volumn 356, Issue 2, 2001, Pages 487-493

  Weingand Ziade, A ^a   Ribes, F ^a   Renault, F ^a   Masson, P ^a  

^a CENTRE DE RECHERCHES   (France)

Author keywords

Cholinesterase; Denaturation of intermediates; Temperature

Indexed keywords

CATALYSIS; ESTERS; IODINE; NITROGEN;

SERIES-INACTIVATION PROCESS;

BIOCHEMISTRY;

BUTYRYLTHIOCHOLINE; CHOLINESTERASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME DENATURATION; ENZYME INACTIVATION; ENZYME KINETICS; HEAT; MICHAELIS CONSTANT; PRESSURE; PRIORITY JOURNAL;

BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; HEAT; HUMANS; KINETICS; MODELS, CHEMICAL; PRESSURE; PROTEIN CONFORMATION; PROTEIN DENATURATION; THERMODYNAMICS;

EID: 0035366655     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3560487     Document Type: Article

References (48)

1. Molecular and cellular biology of cholinesterases
2. Comparison of butyrylcholinesterase and acetylcholinesterase
3. The key role of butyrylcholjnesterase during neurogenesis and neural disorders: An antisense-5′ butyrylcholinesterase-DNA study
4. Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure
5. Genetic variants of human serum butyrylcholinesterase influence the metabolism of the muscle relaxant sucinylchloine
6. Butyrylcholinesterase: An enzyme antidote for cocaine intoxication
7. The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase
8. Butyrylcholinesterase accelerates cocaine metabolism: In vitro and in vivo effects in nonhuman primates and humans
9. Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity: In vitro and in vivo quantitative characterization
10. Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: Design, construction and characterization
11. An improved cocaine hydrolase: The A328Y mutant of human butyrylcholinesterase is 4-fold more efficient
12. Acetylcholinesterase: Enzyme structure, reaction dynamics; and virtual transition states
13. Acetylcholinesterase
14. Atomic structure of acetylcholinesterase from Torpedo california: A prototypic acetylcholine-binding protein
15. Conversion of acetylcholinesterase to butyrylcholinesterase: Modeling and mutagenesis
16. Conformational plasticity of butyrylcholinesterase as revealed by high pressure experiments
17. Polyolinduced activation by excess substrate of the D70G butyrylcholinesterase mutant
18. Resistance of butyrylcholinesterase to inactivation by ultrasound: Effects of uitrasound on catalytic activity and subunit association
19. Hydration change during the aging of phosphorylated human butyrylcholinesterase: Importance of residues D70 and E197 in the water network as probed by hydrostatic and osmotic pressures
20. Pressure and propylene carbonate denaturation of native and "aged" phosphorylated cholinesterase
21. Pressure-induced molten globule state of cholinesterase
22. Combined-pressure/heat-induced inactivation of butyrylcholinesterase
23. Differential effect of pressure and temperature on the catalytic behaviour of wild-type human butyrylcholinesterase and its D70G mutant
24. Kinetics of butyrylcholinesterase in reversed micelles under high pressure
25. Pressure-induced structural modifications of butyrylcholinesterase
26. Substrate activation and thermal denaturation kinetics of the tetrameric and the trypsin-generated monomeric forms of horse serum butyrylcholinesterase
27. Stability of butyrylcholinesterase: Thermal inactivation in water and deuterium oxide
28. Turnover rime of acetylcholinesterase
29. The number of catalytic sites in acetylcholinesterase
30. A new and rapid colorimetric determination of acetylcholinesterase activity
31. Reaction volume of protonic ionization for buffering agent. Prediction of pressure dependence of pH and pOH
32. The thermal stability of turnip yellow mosaic virus under hydrostatic pressure
33. A "direct-coloring" thiocholine method for cholinesterases
34. Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
35. Role of aspartate 70 and tryptophan 82 in binding of succinyldithiochioline to human butyrylcholinesterase
36. Asp 70 in the peripheral anionic site of human butyrylcholinesterase
37. Thermal stability of acetylcholinesterase from Bungarus fasciatus venom as investigated by capillary electrophoresis
38. Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates
39. High pressure effects on-protein-structure and function
40. Pressure effects on enzyme activity and stability at high temperatures
41. Conformational changes of proteins
42. Single-step unimolecular non-first-order enzyme deactivation kinetics
43. Conformational change, fluctuation and drift in biological macromolecules: An empirical Langevin approach
44. Dynamics of oligomeric proteins
45. Pressure dissociation and conformational drift of the β dimer of tryptophan synthase
46. Hysteresis and conformational drift of pressure-dissociated glyceraldehydephosphate dehydrogenase