Production of β-Thujaplicin in Cupressus lusitanica Suspension Cultures Fed with Organic Acids and Monoterpenes

Bioscience, Biotechnology and Biochemistry

Volumn 65, Issue 5, 2001, Pages 1027-1032

  Zhao, Jian ^a,b   Fujita, Koki ^a   Sakai, Kokki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

thujaplicin; Biosynthesis; Cupressus lusitanica; Monoterpene; Organic acid

Indexed keywords

ACID; BETA-THUJAPLICIN; DRUG DERIVATIVE; TERPENE; THUJAPLICIN; TROPOLONE;

ARTICLE; CITRIC ACID CYCLE; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; KINETICS; METABOLISM; TREE;

ACIDS; CELL CULTURE TECHNIQUES; CITRIC ACID CYCLE; CULTURE MEDIA; KINETICS; MONOTERPENES; TERPENES; TREES; TROPOLONE;

EID: 0035348525     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.65.1027     Document Type: Article

References (22)

1. Trust, T. J., and Coombs, R. W., Antibacterial activity of β-thujaplicin. Can. J. Microbiol., 19, 1341-1347 (1973).
2. Okabe, T., Saito, K., and Otomo, Y., Antimicrobial activity and safety of Hinokitiol. Fragrance J., 17, 74-79 (1989).
3. Miyamoto, D., Endo, N., Oku, N., Arima, Y., Suzuki, T., and Suzuki, Y., beta-Thujaplicin zinc chelate induces apoptosis in mouse high metasatic melanoma B16B16 cells. Biological & Pharmaceutical Bulletin, 21, 1258-1262 (1998).
4. Erdtman, H., Conifer chemistry and taxonomy of conifers. In: Kratzl K, Billek G (eds) Biochemistry of Wood, Proc 4th Int Congr. Biochem. Pergamon Press, London, pp. 1-27 (1959).
5. Bently, R., Biosynthesis of tropolones in Penicilium stipitum. J. Biol. Chem., 238, 1895-1903 (1963).
6. Croteau, R., and Johnson, M. A., Biosynthesis of terpenoid wood extractives. In: Higuchi T (ed) Biosynthesis and Biodegradation of Wood Components. Academic Press, Orlando, pp. 397-439 (1985).
7. Sakai, K., Kusaba, K., Tsutsumi, Y., and Shirashi, T., Secondary metobolites in cell culture of woody plants III. Formation of β-thujaplicin in Cupressus lusitanica callus cultures treated with fungal elicitors. Mokuzai Gakkaishi., 40, 1-5 (1994).
8. Itose, R., and Sakai, K., Improved culture condition s for the production of β-thujaplicin by suspension cell cultures of Cupressus lusitanica. Plant Biotechnol., 14, 163-167 (1997).
9. Yamaguchi, T., Itose, R., and Sakai, K., Biosynthesis of heartdwood tropolones I. Incorporation of mevalonate and acetate into β-thujaplicin (hinokitiol) of Cupressus lusitanica cell culture. J. Fac. Agric. Kyushu Univ., 42, 131-138 (1997).
10. Fujita, K., Yamaguchi, Y., and Sakai, K., Biosynthesis of β-thujaplicin in the Cupressus lusitanica suspension cell culture. J. Plant Physiol., 156, 462-467 (2000).
11. Zhao, J., Fujita, K., Yamada, J., and Sakai, K., Improved β-thujaplicin production in Cupressus lusitanica suspension cultures by fungal elicitor and methyl jasmonate. Appl. Microbiol. Biotechnol., 55, in press (2001).
12. Endo, M., Mizutani, T., Matsumura, M., Moriyasu, M., Ichimaru, M., Kato, A., and Hashimoto, Y., High-performance liquid chromatographic determination of hinokitiol in cosmetics by the formation of difluoroborane compounds. J. Chromatog., 455, 430-433 (1988).
13. Ono, M., Asai, T., and Watanabe, H., Hinokitol production in a suspension culture of Calocedrus formosana Florin. Biosci. Biotechnol. Biochem., 62, 1653-1659 (1998).
14. Zhao, J., Zhu, W. H., Hu, Q., and He, X. W., Improved indole alkaloid production in Catharanthus roseus suspension cell cultures by various chemicals. Biotechnol. Lett., 22, 1221-1226 (2000).
15. Pitta-Alvarez, S. I., and Giulietti, A. M., Influence of chitosan, acetic acid and citric acid on growth and tropane alkaloid production in transformed roots of Brugmansia candida: Effects of medium pH and growth phase. Plant Cell Tiss. Org. Cult., 59, 31-38 (1999).
16. Brownleader, M. D., Harborne, J. B., and Dey, P. M., Carbohydrate metabolism: primary metabolism of monosaccharides. In: Dey, P. M., Harborne, J. B., (eds), Plant Phytochemistry, Academic Press, London, pp. 111-140 (1997).
17. Brown, M. S., Faust, J. R., and Goldstein, J. L., Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236-B), a competitive inhibitor of the reductase. J. Biol. Chem., 235, 1121-1128 (1978).
18. Charlwood, B. V., and Banthorpe, D. V., In: Reinhold L, Harbone JB, Swain T (eds), Progress in Phytochemistry, Vol. 5. Pergaman, Oxford, pp. 65-125 (1978).
19. Bohlmann, J., Meyer-Gauen, G., and Croteau, R., Plant terpenoid synthesis: molecular biology and phytogenetic analysis. Proc. Natl. Acad. Sci. USA., 91, 4126-4133 (1998).
20. Lewinsohn, E., Gijzen, M., Savage, T. J., and Croteau, R., Defense mechanisum of conifers. Plant Physiol., 96, 38-43 (1991).
21. Lichtenthaler, H. K., Rohmer, M., and Schwender, J., Two independent biochemical pathways for isopentenyl diphosphate and isoprenoid biosynthesis in higher plants. Physiol. Plant., 101, 643-652 (1997).
22. McCaskill, D., and Croteau, R., Some caveats for bioenginerring terpenoid metabolism in plants. Trends in Biotechnol., 16, 349-355 (1998).