Immunization to Porphyromonas gingivalis enhances the local pro-inflammatory response to subcutaneous bacterial challenge

Journal of Clinical Periodontology

Volumn 28, Issue 5, 2001, Pages 476-482

  Houri Haddad, Yael ^a   Soskolne, W Aubrey ^a   Shapira, Lior ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Cytokines; Immune response; Immunization; Inflammation; Porphyromonas gingivalis

Indexed keywords

ALUMINUM POTASSIUM SULFATE; ALUMINUM SULFATE; BACTERIAL ANTIGEN; BACTERIUM ANTIBODY; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BLOOD; CELLULAR IMMUNITY; COMPARATIVE STUDY; DIFFUSION CHAMBER; EXUDATE; FEMALE; FOLLOW UP; IMMUNIZATION; IMMUNOLOGY; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MONOCYTE; MOUSE; NEUTROPHIL; PATHOLOGY; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SKIN; STATISTICS; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ALUM COMPOUNDS; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; DIFFUSION CHAMBERS, CULTURE; EXUDATES AND TRANSUDATES; FEMALE; FOLLOW-UP STUDIES; FREUND'S ADJUVANT; IMMUNITY, CELLULAR; IMMUNIZATION; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-10; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MICE; MONOCYTES; NEUTROPHILS; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SKIN; STATISTICS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035347539     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-051x.2001.028005476.x     Document Type: Article

References (25)

1. Baker, P. J., Evans, R. T. & Roopenian, D. C. (1994) Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Archives in Oral biology 39, 1035-1040.
2. Frolov, I., Houri-Haddad, Y., Soskolne, A. & Shapira, L. (1998) In vivo exposure to Porphyromonas gingivalis up-regulates nitric oxide but suppresses tumor necrosis factor alpha production by cultured macrophages. Immunology 93, 323-328.
3. Gemmell, E., Bird, P. S., Bowman, J. J. D., Xu, L., Polak, B., Walsh, L. J. & Seymour, G. J. (1997) Immuno-histological study of lesions induced by Porphyromonas gingivalis in a murine model. Oral Microbiology and Immunology 12, 288-297.
4. Gemmell, E., Winning, T. A., Bird, P. S. & Seymour, G. J. (1998) Cytokine profiles of lesional and splenic T cells in Porphyromonas gingivalis infection in a murine model. Journal of Periodontology 69, 1131-1138.
5. Genco, C. A. & Arko, R. J. (1994) Animal chamber models for study of host-parasite interactions. Methods in Enzymology 235, 120-140.
6. Hart, T. C., Shapira, L. & Van Dyke, T. E. (1994) Neutrophil defects as a risk factor for periodontal diseases. Journal of Periodontology 65, 521-529.
7. Holt, S. C. & Bramanti, T. E. (1991) Factors in virulence expression and their role in periodontal disease pathogenesis. Critical Reviews in Oral Biology and Medicine 2, 177-281.
8. Kesavalu, L., Ebersole, J. L., Machen, R. L. & Holt, S. C. (1992) Porhyromonas gingivalis virulence in mice: Induction of immunity to bacterial components. Infection and Immunity 60, 1455-1464.
9. Kojima, T., Yano, K. & Ishikawa, I. (1997) Relationship between serum antibody levels and subgingival colonization of Porphyromonas gingivalis in patients with various types of periodontitis. Journal of Periodontology 68, 618-625.
10. Lehr, H. A. & Arfors, K. E. (1994) Mechanism of tissue damage by leukocytes. Current Opinion in Hematology 1, 92-99.
11. Miyasaki, K. T. (1991) The neutrophil: mechanism of controlling periodontal bacteria. Journal of Periodontology 62, 761-774.
12. Miyazaki, H., Pilot, T., Leclercq, M. H. & Barmes, D. E. (1991a) Profiles of periodontal conditions in adolescents measured by CPITN. International Dental Journal 41, 67-73.
13. Miyazaki, H., Pilot, T., Leclercq, M. H. & Barmes, D. E. (1991b) Profiles of periodontal conditions in adults measured by CPITN. International Dental Journal 41, 74-80.
14. Mooney, J. & Kinane, D. F. (1997) Levels to specific immunoglobulin G tp Porphyromonas gingivalis in gingival crevicular fluid are related to site disease status. Oral Microbiology and Immunology 12, 112-116.
15. Okuda, K., Saito, T., Hirai, K., Harano, K. & Kato, T. (1994) Rôle of antibodies in periodontopathic bacterial infection. In: Genco, R., Hamada, S., Lehner, T., McGhee, J. & Mergenhagen, S. (eds.): Molecular pathogenesis of periodontal disease. ASM Press, Washington DC, pp. 257-265.
16. Person, G. R., Engel, D., Whitney, C., Darveau, R., Weinberg, A., Brunsvold, M. & Page, R. C. (1994) Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates. Infection and Immunity 62, 1026-1031.
17. Rossomando, E. F., Kennedy, J. E. & Hadjimichael, J. (1990) Tumor necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans. Archives in Oral biology 35, 431-434.
18. Shapira, L., Soskolne, A., Halabi, A., Barak, V. & Stabholz, Z. (1997) Induction of tumor necrosis factor alpha and interleukin 1 beta in subcutaneously implanted chamber by lipopolysaccharide. Journal of Endotoxin Research 4, 325-329.
19. Sjostrom, K., Darveau, R., Page, R. C., Whitney, C. & Engel, D. (1992) Opsonic antibody activity against Actinobacillus actinomycetemcomitans in patients with rapidly progressive periodontitis. Infection and Immunity 60, 4819-4825.
20. Snapper, C. M. & Mond, J. J. (1993) Towards a comprehensive view of immunoglobulin class switching. Immunology Today 15, 15-17.
21. Socransky, S. S. & Haffajee, A. D. (1992) The bacterial etiology of destructive periodontal disease: current concepts. Journal of Periodontology 63, 322-331.
22. Stashenko, P., Jandinski, J. J., Fujiyioshi, P., Rynar, J. & Socranski, S. S. (1991) Tissue levels of bone resorptive cytokines in periodontal disease. Journal of Periodontology 62, 504-509.
23. Underwood, K., Sjostrom, K., Darveau, R., Lamont, R., Schenkein, H., Gunsolley, J., Page, R. C. & Engel, L. D. (1993) Serum antibody opsonic antibody activity against Actinobacillus actinomycetemcomitans in periodontal diseases. Journal of Infectious Diseases 168, 1436-1443.
24. Van Dyke, T. E., Lester, M. A. & Shapira, L. (1993) The role of host response in periodontal disease progression: implications for future treatment strategies. Journal of Periodontology 64, 792-806.
25. Weiss, S. J. (1989) Tissue destruction by neutrophils. New England Journal of Medicine 320, 365-376.