LPS inhibitors: Key to overcoming multidrug-resistant bacteria?

Drug Discovery Today

Volumn 6, Issue 10, 2001, Pages 499-500

  Sansom, Clare ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 DEOXY D MANNO OCTULOSONIC ACID 8 PHOSPHATE SYNTHASE; 3 DEOXY MANNO OCTULOSONIC ACID; ANTIBIOTIC AGENT; ENZYME INHIBITOR; LIPOPOLYSACCHARIDE; PD 404182; UNCLASSIFIED DRUG;

DRUG DEVELOPMENT; ENZYME STRUCTURE; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; MULTIDRUG RESISTANCE; NONHUMAN; SHORT SURVEY;

EID: 0035339062     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)01804-9     Document Type: Short Survey

References (3)

1. Birck M.R., et al. Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J. Am. Chem. Soc. 122:2000;9334-9335.
2. Duewel H.S., et al. Substrate and metal complexes of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus at 1.9A resolution. J. Biol. Chem. 276:2001;8393-8402.
3. Birck M.R., Woodard R.W. Aquifex aeolicus 3-deoxy-D-manno-2-octulosonic acid 8-phosphate synthase: a new class of KDO 8-P synthase. J. Mol. Evol. 52:2001;205-214.