Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction

Journal of Physiology

Volumn 532, Issue 3, 2001, Pages 637-647

  Naves, Ligia A ^a,c   Van Der Kloot, William ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b Boat House   (United Kingdom)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CHOLINERGIC RECEPTOR STIMULATING AGENT; HEMICHOLINIUM 3; NEOSTIGMINE; VESAMICOL; POTASSIUM CHANNEL;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; EXCITATION CONTRACTION COUPLING; FROG; IONTOPHORESIS; MINIATURE ENDPLATE POTENTIAL; MOTOR NERVE; MUSCLE CONTRACTION; NERVE STIMULATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; STIMULUS; SYNAPSE VESICLE; TIME; ACTION POTENTIAL; ANIMAL CELL; CELL MEMBRANE DEPOLARIZATION; CELL VACUOLE; CELLULAR PARAMETERS; MEMBRANE ELECTROPHYSIOLOGY; NERVE CELL STIMULATION; NERVE ENDING; NEUROTRANSMISSION; RANA PIPIENS; SYNAPTIC POTENTIAL;

ACETYLCHOLINE; ANIMALS; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; CHOLINERGIC AGENTS; CHOLINESTERASE INHIBITORS; DIMETHYLPHENYLPIPERAZINIUM IODIDE; ELECTRIC STIMULATION; HEMICHOLINIUM 3; MEMBRANE POTENTIALS; MOTOR NEURONS; NEOSTIGMINE; NEUROMUSCULAR DEPOLARIZING AGENTS; NEUROMUSCULAR JUNCTION; NICOTINE; NICOTINIC AGONISTS; PATCH-CLAMP TECHNIQUES; PIPERIDINES; RANA PIPIENS; SYNAPTIC VESICLES; UNCOUPLING AGENTS;

EID: 0035338815     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.0637e.x     Document Type: Article

References (41)

1. The amplitude of quantal currents is reduced during short-term depression at neuromuscular synapses in Drosophila
2. The synaptic vesicle cycle
3. Vesicle hypothesis of the release of quanta of acetylcholine
4. A new method for excitation-contraction uncoupling in frog skeletal muscle
5. Changes in miniature end-plate potentials after brief nervous stimulation at the frog neuromuscular junction
6. Development of desensitization during repetitive end-plate activity and single end-plate currents in frog muscle
7. Changes in miniature end-plate currents due to high potassium and calcium at the frog neuromuscular junction
8. Regulation of acetylcholine synthesis in the presence of hemicholinium mustard
9. Statistical methods for model descrimination
10. On the factors which determine the amplitude of the 'miniature endplate potential'
11. Presynaptic ionotropic receptors and the control of transmitter release
12. Quantal nature of synaptic transmission
13. Effects of carbonyl cyanide m-chlorophenylhydrazone (CCCP) on quantal transmitter release and ultrastructure of frog motor nerve terminals
14. Monoethylcholine as a false transmitter precursor at the frog and mouse neuromuscular junctions
15. Transmitter packaging at frog neuromuscular junctions exposed to anticholinesterases; the role of second stage acetylcholine loading
16. Empty synaptic vesicles recycle and undergo exocytosis at vesamicol-treated motor nerve terminals
17. Acetylcholine transport, storage, and release
18. Hemicholinium-3 facilitates the release of acetylcholine by acting on presynaptic nicotinic receptors at a central synapse in Aplysia
19. The pharmacology of vesamicol: An inhibitor of the vesicular acetylcholine transporter
20. Two endocytic recycling routes selectively fill two vesicle pools in frog motor nerve terminals
21. The membrane hyperpolarization of rat dorsolateral septal nucleus neurons is mediated by a novel nicotinic receptor
22. Miniature endplate current rise times < 100 μs from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle
23. Regulation of quantal size by presynaptic mechanisms
24. Hexamethonium- and methyllycacoconitine-induced changes in acetylcholine release from rat motor nerve terminals
25. Immunohistochemical localization of neuronal nicotinic receptor subtypes at the pre- and postjunctional sites in mouse diaphragm muscle
26. Inhibition of packing of acetylcholine into quanta by ammonium
27. The regulation of quantal size
28. Nicotinic agonists antagonize quantal size increases and evoked release at frog neuromuscular junction
29. Statistics for studying quanta at synapses: Resampling and confidence limits on histograms
30. Making quantal analysis easier and more accurate
31. The timing of channel opening during miniature endplate currents at the frog and mouse neuromuscular junctions: Effects of fasciculin-2, other anti-cholinesterases and vesamicol
32. Calcitonin gene-related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions
33. Recycling and refilling of transmitter quanta at the frog neuromuscular junction
34. Quantal acetylcholine release at the vertebrate neuromuscular junction
35. Accounting for the shapes and size distributions of miniature endplate currents
36. Numerical reconstruction of the quantal event at nicotinic synapses
37. Presynaptic inhibition of elicited neurotransmitter release
38. High affinity transport of choline into synaptosomes of rat brain
39. Increasing quantal size at the mouse neuromuscular junction and the role of choline