Gene dosage-dependent functions for phosphotyrosine-grb2 signaling during mammalian tissue morphogenesis

Current Biology

Volumn 11, Issue 9, 2001, Pages 662-670

  Saxton, Tracy M ^a,b,c   Cheng, Alec M ^a   Ong, Siew Hwa ^a   Lu, Yong ^a   Sakai, Ryuichi ^a   Cross, James C ^a,b   Pawson, Tony ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHOSPHOTYROSINE; ADAPTOR PROTEIN; BINDING KINETICS; BIOCHEMICAL PATHWAY; CELL DIFFERENTIATION; CELL MUTANT; FIBROBLAST; HETEROZYGOSITY; MITOGEN ACTIVATED PROTEIN KINASE; MORPHOGENESIS; MORPHOLOGY; PHOSPHATIDYLINOSITOL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN TYROSINE KINASE; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0035337295     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00198-1     Document Type: Article

References (50)

1. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
2. Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries
3. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
4. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro
5. Guaninenucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling
6. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
7. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
8. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
9. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation
10. Signaling through scaffold, anchoring, and adaptor proteins
11. Increasing complexity of the Ras signaling pathway
12. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator
13. The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5
14. A Grb2-associated docking protein in EGF- and insulinreceptor signaling
15. Association of Ash/Grb-2 with dynamin through the Src homology 3 domain
16. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
17. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases
18. Association of the Shc and Grb2/Sem5 SH2containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
19. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signaling
20. A lipid-anchored Grb2-binding protein that links FGFreceptor activation to the Ras/MAPK signaling pathway
21. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
22. C. elegans cell-signaling gene sem-5 encodes a protein with SH2 and SH3 domains
23. Craniofacial defects in AP-2 null mutant mice
24. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure
25. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
26. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
27. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
28. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
29. The Sos1 and Sos2 Ras-specific exchange factors: Differences in placental expression and signaling properties
30. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
31. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen- activated protein kinase activation
32. Essential role of Gab1 for signaling by the c-Met receptor in vivo
33. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
34. Cellular and molecular biology of neural crest cell lineage determination
35. Neural crest diversification
36. Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos
37. Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis
38. Morphological and biochemical characterization and analysis of apoptosis
39. Apoptosis: Identification of dying cells
40. The Trk family of neurotrophin receptors
41. Steel factor and c-kit receptor: From mutants to a growth factor system
42. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
43. Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
44. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
45. Modulation of cellular apoptotic potential: Contributions to oncogenesis
46. Multiple developmental roles of VEGF suggested by a LacZ-tagged allele
47. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
48. Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2
49. Epidermal growth factor receptor as a mediator of developmental toxicity of dioxin in mouse embryonic teeth
50. Antagonistic interactions between FGF and BMP signaling pathways: A mechanism for positioning the sites of tooth formation