Formamidopyrimidine-DNA glycosylase enhances arsenic-induced DNA strand breaksin PHA-stimulated and unstimulated human lymphocytes

Environmental Health Perspectives

Volumn 109, Issue 5, 2001, Pages 523-526

  Li, Dasheng ^a   Morimoto, Kanehisa ^a,b   Takeshita, Tatsuya ^a   Lu, Yuquan ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Arsenic; Comet assay; Formamidopyrimidine DNA glycosylase (FPG); Human lymphocytes; Oxidative DNA damage

Indexed keywords

ARSENIC; DNA BASE; DNA GLYCOSYLTRANSFERASE; FORMAMIDOPYRIMIDINE DNA GLYCOSYLTRANSFERASE; HYDROGEN PEROXIDE; PHYTOHEMAGGLUTININ; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DNA DAMAGE; DNA DETERMINATION; DNA REPAIR; DNA STRAND BREAKAGE; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME MECHANISM; HUMAN; HUMAN CELL; INCUBATION TIME; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; TOXICITY TESTING;

EID: 0035325084     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.01109523     Document Type: Article

References (28)

1. Is the genotoxic effect of arsenic mediated by oxygen free radicals?
2. Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species
3. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
4. Glutathione peroxidase and catalase modulate the genotoxicity of arsenite
5. Arsenic induces DNA damage via reactive oxygen species in human cells
6. Kinetics The of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells
7. Oxidative damage to DNA: Formation, measurement, and biological significance
8. Endonucleolytic activity from Micrococcus luteus that acts on gamma ray induced damage in plasmid DNA of E. coli minicells
9. Measurement of M. luteus endonuclease-sensitive lesions by alkaline elution
10. Induction and repair of DNA base damage studied in X-irradiated CHO cells using the M. luteus extract
11. Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair
12. The comet assay: What can it tell us?
13. DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells
14. NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells
15. The role of oxidative DNA damage in human arsenic carcinogenesis: Detection of 8-hydroxy-2′-deoxyguanosine in arsenic-related Bowen's disease
16. A simple technique for quantitation of low levels of DNA damage in individual cells
17. Oxidative base damage to DNA: Specificity of base excision repair enzyme
18. Distinct repair activity of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine
19. Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation
20. Radiation-induced DNA base damage detected in individual aerobic and hypoxic cells with endonuclease III and formamidopyrimidine-glycosylase
21. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
22. Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblast
23. Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite
24. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis
25. The effects of hydrogen peroxide on DNA repair activities
26. Reactive oxygen species: Their relation to pneumoconiosis and carcinogenesis
27. Reactive oxygen species-induced molecular damage and its application in pathology
28. Repair of DNA damage induced by oxygen radicals in human non-proliferating and proliferating lymphocytes