The CC chemokine receptor 5 Δ32 mutation is not associated with inflammatory bowel disease (IBD) in NE England

Genes and Immunity

Volumn 2, Issue 2, 2001, Pages 114-116

  Craggs, A ^a   Welfare, M ^a   Donaldson, P T ^a,b   Mansfield, J C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

CCR5 32 mutation; Crohn's disease (CD); Genetic polymorphism; Inflammatory bowel disease (IBD); Ulcerative colitis (UC)

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ARTICLE; CROHN DISEASE; GENE FREQUENCY; GENETICS; HUMAN; MUTATION; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; ULCERATIVE COLITIS; UNITED KINGDOM;

COLITIS, ULCERATIVE; CROHN DISEASE; ENGLAND; GENE FREQUENCY; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; RECEPTORS, CCR5;

EID: 0035321129     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363735     Document Type: Article

References (24)

1. Satsangi J, Parkes M, Jewell DP, Bell JI. Genetics of inflammatory bowel disease. Clin Sci 1998; 94: 473-478.
2. Monsen U, Brostrom O, Nordenvall B, Sorstad J. Prevalence of inflammatory bowel disease among relatives of patients with ulcerative colitis. Scand J Gastroenterol 1987; 22: 214-218.
3. Orholm M, Munkholm P, Langholz E, Nielsen OH, Sorensen IA, Binder V. Familial occurrence of inflammatory bowel disease. N Engl J Med 1991; 324: 84-88.
4. Tysk C, Linberg E, Jarnerot G, Floderus-Myrhed. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins: a study of heritability and the influence of smoking. Gut 1988; 29: 990-996.
5. Satsangi J, Parkes M, Louis E et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 1996; 14: 199-202.
6. Louis E, Satsangi J, Roussomoustakaki M et al. Cytokine gene polymorphisms in inflammatory bowel disease. Gut 1996; 39: 705-710.
7. Baggiolini M. Chemokines and leukocyte traffic. Nature 1998; 392: 565-568.
8. Alkhatib G, Combadiere C, Broder CC et al. CC-CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996; 272: 1955-1958.
9. Wolinsky SM, Korber BTM, Neumann AU et al. Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection. Science 1996; 272: 537-542.
10. Samson M, Soularue P, Vassart G, Parmentier M. The genes encoding the human CC-chemokines receptors CC-CKR1 to 5 are clustered in the p21.3-p24 region of chromosome 3. Genomics 1996; 36: 522-526.
11. Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet 1997; 16: 100-103.
12. Paxton WA, Martin SR, Tse D et al. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure. Nat Med 1996; 2: 412-417.
13. Samson M, Libert F, Doranz BJ et al. Resistance to HIV infection in Caucasian individuals bearing mutant alleles of the CCR5 chemokine receptor gene. Nature 1996; 382: 722-725.
14. Liu R, Paxton WA, Choe S et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996; 86: 367-377.
15. Michael NL, Chang G, Louie LG et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med 1997; 3: 338-340.
16. Gomez-Reino JJ, Pablos JL, Carreira PE et al. Association of rheumatoid arthritis with a functional chemokine receptor, CCR5. Arthritis & Rheumatism 1999; 42: 989-992.
17. Sellebjerg F, Madsen HO, Jensen CV, Jensen J, Garred P. CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis. J Neuroimmunol 2000; 102: 98-106.
18. Barcellos LF, Schito AM, Rimmler JB et al. CC-chemokine receptor 5 polymorphism and age onset in familial multiple sclerosis. Immunogenetics 2000; 51: 281-288.
19. Szalai C, Csazar A, Czinner A et al. Chemokine receptor CCR2 and CCR5 polymorphisms in children with insulin-dependent diabetes mellitus. Pediatric Res 1999; 46: 82-84.
20. Simmons JD, Marshall SEF, Welsh KI, Jewell DP. The CCR5 32 base pair deletion confers susceptibility to ulcerative colitis and Crohn's disease. Gut 1999; 44 (Suppl 1): A44 (Abstr. W173).
21. Gambaro G, Anglani F, D'Angelo A. Association studies of genetic polymorphisms and complex disease. Lancet 2000; 355: 308-311.
22. Anonymous. Freely associating. Nat Genet 1999; 22: 1-2.
23. Wang J, Guan E, Roderiquez G, Norcross MA. Inibition of CCR5 expression by IL-12 through induction of beta-chemokine in human T lymphocytes. J Immunol 1999; 163: 5763-5769.
24. Bailer RT, Lee B, Montaner LJ. IL-13 and TNF-alpha inhibit dual-tropic HIV-1 in primary macrophages by reduction of surface expression of CD4, chemokine receptors CCR5, CXCR4 and post-entry viral gene expression. Eur J Immunol 2000; 30: 1340-1349.