A full genome screening in a large Tunisian family affected with thyroid autoimmune disorders

Genes and Immunity

Volumn 2, Issue 2, 2001, Pages 71-75

  Maalej, A ^a   Makni, H ^a   Ayadi, F ^b   Bellassoued, M ^c   Jouida, J ^d   Bouguacha, N ^a   Abid, M ^c   Ayadi, H ^a  

^a UNIVERSITY OF SFAX   (Tunisia)

^b HABIB BOURGUIBA HOSPITAL   (Tunisia)

^c HEDI CHAKER HOSPITAL   (Tunisia)

^d Dispensaire de Bir EI Hfai   (Tunisia)

Author keywords

Autoimmune thyroid disorders; Genome screening; Linkage study; Susceptibility gene

Indexed keywords

MICROSATELLITE DNA;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE THYROIDITIS; CHILD; CHROMOSOME 2; FEMALE; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; GENOTYPE; GRAVES DISEASE; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; PEDIGREE; TUNISIA;

ADOLESCENT; ADULT; CHILD; CHROMOSOMES, HUMAN, PAIR 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; GRAVES DISEASE; HUMANS; LINKAGE (GENETICS); MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PEDIGREE; THYROIDITIS, AUTOIMMUNE; TUNISIA;

EID: 0035319849     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363736     Document Type: Article

References (28)

1. Tunbridge WMG, Evered DC, Hall R et al. The spectrum of thyroid disease in a community: the Wickham survey. Clin Endocrinol 1977; 7: 481.
2. DeGroot LJ, Quintans J. The causes of autoimmune thyroid disease. Endocr Rev 1989; 10: 537-562.
3. Weetman AP, McGregor AM. Autoimmune thyroid disease: further development in our understanding. Endocr Rev 1994; 15: 788-830.
4. Tomer Y, Davies TF. Infection, thyroid disease and autoimmunity. Endocr Rev 1993; 14: 107-120.
5. Mather BA, Roberts DF, Scanlon MF et al. HLA antigens and thyroid autantibodies in patients with Graves' disease and their first degree relatives. Clin Endocrinol (Oxf) 1980; 12: 155-163.
6. Vyse TJ, Todd JA. Genetic analysis of autoimmune disease. Cell 1996; 85: 311-318.
7. Stenszky V, Kozma L, Balazs CS, Bear JC, Farid NR. The role of HLA antigens in the manifestations and course of Graves' disease. Mol Biol Med 1986; 3: 53.
8. Brix TH, Christensen K, Niels VH, Harvald B, Hegedus L. Genetic vs environment in Graves' disease a population based twin study. Thyroid 1997; 7: S-13.
9. Payami H, Joe S, Thomson G. Autoimmune thyroid disease in type 1 diabetes. Genet Epidemiol 1989; 6: 137-141.
10. Yanagawa T, Mangklabruks A, Chang YB et al. Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a Caucasian population. J Clin Endocrinol Metab 1993; 76: 1569-1574.
11. Nakao Y, Matsumoto H, Miyazaki T et al. IgG heavy chain allotypes (Gm) in atrophic and goitrous thyroiditis. Clin Exp Immunol 1980; 42: 20-26.
12. Fakhfakh F, Maalej A, Makni H et al. Analysis of immunoglobulin VH and TCR Cβ polymorphisms in a large family with thyroid autoimmune disorder. Exp Clin Immunogenet 1999; 16: 185-191.
13. Pickerill AP, Watson PF, Tandon N, Weetman AP. Tcell receptor beta chain gene polymorphisms in Graves' disease. Acta Endocrinol 1993; 128: 499-502.
14. De Roux N, Shields DC, Misrahi M, Ratanachaiyavong S, McGregor AM, Milgrom E. Analysis of the thyrotropin receptor as a candidate gene in familial Graves' disease. J Clin Endocrinol Metab 1996; 81: 3483-3486.
15. Pirro MT, De Filippis V, Di Cerbo A, Scillitani A, Liuzzi A, Tassi V. Thyroperoxidase microsatellite polymorphism in thyroid disease. Thyroid 1995; 5: 461-164.
16. Roman SH, Greenberg D, Rubinstein P, Wallenstein S, Davies TF. Genetics of autoimmune thyroid disease: lack of evidence for linkage to HLA within families. J Clin Endocrinol Metab 1992; 74: 496-503.
17. Tomer Y, Barbesino G, Keddache M, David A. Greenberg DA, Davies TF. Mapping of a major susceptibility locus for Graves' disease (GD1) to chromosome 14q31. J Clin Endocrinol Metab 1997; 82: 1645-1648.
18. Barbesino G, Tomer Y, Concepcion ES, Davies TF, Greenberg DA and the International Consortium for the Genetics of Autoimmune Thyroid Disease. Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. J Clin Endocrinol Metab 1998; 83: 3290-3295.
19. Tomer Y, Barbesino G, Greenberg DA, Conception E, Davies TF and the International Consortium for the Genetics of Autoimmune Thyroid Disease. A new Graves' disease-susceptibility locus maps to chromosome 20q11.2. Am J Hum Genet 1998; 63: 1749-1756.
20. Vaidya B, Imrie H, Perros P et al. The cytotoxic T lymphocyte antigen is a major Graves' disease locus. Hum Mol Genet 1999; 8: 1195-1199.
21. Vaidya B, Imrie H, Perros P et al. Evidence for a new Graves' disease susceptibility locus at chromosome 18q21. Am J Hum Genet 2000; 66: 1710-1714.
22. Arawaka H, Nagase H, Hayashi N, Fujiwara T, Ogawa M, Shin S, Nakamura Y. Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. Biochem Biophys Res Commun 1994; 200: 836-843.
23. Shields DC, Ratanachaiyavong S, McGregor AM, Collins A, Morton NE. Combined segregation and linkage analysis of Graves' disease with a thyroid autoantibody diathesis. Am J Hum Genet 1994; 55: 540-554.
24. Barbesino G, Tomer Y, Concepcion E et al. Linkage analysis of candidate genes in autoimmune thyroid disease: 1. Selected immunoregulatory genes. J Clin Endocrinol Metab 1998; 83: 1580-1584.
25. Makni H, Makni-Krichene S, Abid M et al. Prédisposition aux maladies autoimmunes thyroidiennes. La Presse Médicale 1997; 26: 1181-1185.
26. Davis LG, Dibner MD, Battey JF. Basic Methods in Molecular Biology. Elsevier Scientific Publishers: The Netherlands, 1986, p 44.
27. Lathrop GM, Lalouel JM, Julier C, Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 1984; 81: 3443-3446.
28. Greenberg AA, Abreu P, Hodge SE. The power to detect linkage in complex disease by means of simple lod-score analyses. Am J Hum Genet 1998; 63: 870-879.