Sphingolipid Metabolic Changes during Chiral C2-Ceramides Induced Apoptosis in Human Leukemia Cells

Archives of Pharmacal Research

Volumn 24, Issue 2, 2001, Pages 144-149

  Baek, Mi Young ^a   Yoo, Hwan Soo ^a   Nakaya, Kazuyasu ^b   Moon, Dong Cheul ^a   Lee, Yong Moon ^a  

^a Chungbuk National University   (South Korea)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Apoptosis; C2 ceramide; Cell cycle; Sphingosine; Sphingosine kinase

Indexed keywords

CERAMIDE; DNA FRAGMENT; SPHINGOLIPID;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL STRAIN HL 60; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; HUMAN; METABOLISM; PATHOLOGY; PROMYELOCYTIC LEUKEMIA; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CELL CYCLE; CELL SURVIVAL; CERAMIDES; DNA FRAGMENTATION; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; SPHINGOLIPIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035319067     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976482     Document Type: Article

References (14)

1. Bielawska, A., Crane, H. M., Liotta, D., Obeid, L. M., and Hannun, Y. A., Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J. Biol. Chem., 268, 26226 (1993).
2. Chao, R., Khan, W., and Hannun, Y. A., Retinoblastoma protein dephosphorylation induced by D-erythro sphingosine. J. Biol. Chem., 267, 23459 (1992).
3. Cuvillier, O., Edsall, L., and Spiegel, S., Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. J. Biol. Chem., 275, 15691 (2000).
4. Dbaibo, G. S., Pushkareva, M. Y., Jayadev, S., Schwarz, J.K., Horowitz, J. M., Obeid, L. M., and Hannun, Y. A., Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc. Natl. Acad. Sci. USA, 92, 1347 (1995).
5. Huwiler, A., Kolter, T., Pfeilschifter, J. and Sardhoff, K., Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim. Biophys. Acta, 1485, 63 (2000).
6. Jayadev, S., Liu, B., Bielawska, A. E., Lee, J. Y, Nazaire, F., Pushkareva, M. Y, Obeid, L. M. and Hannun, Y. A., Role for ceramide in cell cycle arrest. J. Biol. Chem., 270, 2047 (1995).
7. Merrill, A. H., Schmelz, E. M., Dillehay, D. L., Spiegel, S., Shayman, J. A., Schroeder, J. J., Riley, R. T., Voss, K. A. and Wang, E., Sphingolipids-the enigmatic lipid class: biochemistry, physiology, and pathophysiology Toxicol. Appl. Pharmacol., 142, 208 (1997).
8. Obeid, L. M., Linardic, C. M., Karolak, L. A. and Hannun Y.A., Programmed cell death induced by ceramide. Science, 259, 1769 (1993).
9. Okazaki, T., Bielawski, A., Bell, R. M., and Hannun, Y. A., Role of ceramide as a lipid mediator of 1α, 25- dihydroxyvitamin D3-induced HL-60 cell differentiation. J. Biol. Chem., 265, 15823 (1990).
10. Perry, D. K., and Hannun, Y. H., The role of ceramide in cell signaling. Biochim. Biophys. Acta, 1436, 233 (1998).
11. Ridgway, N. D. and Merriam, D. L., Metabolism of shortchain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells. Biochim. Biophys. Acta, 1256, 57 (1995).
12. Smith, E. R. and Merrill, A. H., Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture. J. Biol. Chem., 270, 18749 (1995).
13. ++ mobilization in human platelets: Evaluation with sphingosine kinase inhibitors. J. Biochem. (Japan), 126, 84 (1999)
14. Yoon, H. T., Yoo, H. S., Shin, B. K., Lee, W. J., Kim, H. M., Hong, S. P., Moon, D. C., and Lee, Y. M., Improved fluorescent determination method of cellular sphingoid bases in high-performance liquid chromatography. Arch. Pharm. Res., 22, 294-299 (1999).