Diaphragm Adaptations Elicited by Severe Chronic Obstructive Pulmonary Disease: Lessons for Sports Science

Exercise and Sport Sciences Reviews

Volumn 29, Issue 2, 2001, Pages 71-75

  Levine, Sanford ^a,c   Nguyen, Taitan ^a   Shrager, Joseph ^a   Kaiser, Larry ^a   Camasamudram, Vijayasarathy ^b   Rubinstein, Neal ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Endurance training; Fast fibers; Fiber type transformation; Mitochondrial oxidative enzymes; Muscle fatigue; Myosin heavy chain; Slow fibers

Indexed keywords

ADENOSINE TRIPHOSPHATE; MYOSIN HEAVY CHAIN;

ADAPTATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIAPHRAGM; EXERCISE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MUSCLE FATIGUE; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ADAPTATION, PHYSIOLOGICAL; ADENOSINE TRIPHOSPHATE; DIAPHRAGM; EXERCISE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG DISEASES, OBSTRUCTIVE; MUSCLE FATIGUE; MYOSIN HEAVY CHAINS;

EID: 0035316578     PISSN: 00916331     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003677-200104000-00006     Document Type: Article

References (15)

1. American Thoracic Society, Medical Section of the American Lung Association. Lung function testing: selection of reference values and interpretative strategies. Am. Rev. Respir. Dis. 144:1202-1218, 1991.
2. Andersen, J.L., P. Schjerling, and B. Saltin. Muscle, genes, and athletic performance. Sci. Am. 283:48-55, 2000.
3. Bellamare, F., and A. Grassino. Force reserve of the human diaphragm in patients with chronic obstructive pulmonary disease. J Appl. Physiol. 55:8-15, 1983.
4. Bellemare, F., and A. Grassino. Force reserve of the diaphragm in patients with chronic obstructive pulmonary disease. J. Appl. Physiol. 55:8-15, 1983.
5. Bernard, P.T., and S. Levine. Critique on the application of diaphragmatic time-tension index to spontaneously breathing human. J. Appl. Physiol. 60:1067-1072, 1986.
6. Fitts, R.H. Celluar, molecular, and metabolic basis of muscle fatigue. In: Handbook of Physiology (Section 12) - Exercise: Regulation and Integration of Multiple Systems, edited by L.B. Rowell and J.T. Shepherd. New York: Oxford, 1996, p. 1151-1183.
7. Jones, N.L., and K.J. Killian. Mechanisms of disease: exercise limitation in health and disease. N. Engl. J. Med. 343:632-641, 2000.
8. Levine, S., L. Kaiser, J. Leferovich, and B. Tikunov. Cellular adaptations in the diaphragm in chronic obstructive pulmonary disease. N. Engl. J Med. 337:1799-1806, 1997.
9. Mercadier, J.J., K. Schwartz, S. Schiaffino, C. Wisnewsky, S. Ausoni, M. Heimburger, R. Marrash, R. Pariente, and M. Aubier. Myosin heavy chain gene expression changes in the diaphragm of patients with chronic lung hyperinflation. Am. J Physiol. 274:L527-L534, 1998.
10. Monod, H., and J. Scherrer. The work capacity of a synergistic muscular group. Ergonomics. 8:329-337, 1965.
11. Nguyen, T., J. Shrager, L. Kaiser, L. Mei, M. Daood, J. Watchko, N. Rubinstein, and S. Levine. Developmental myosin heavy chains in the adult human diaphragm: coexpression patterns and effect of COPD. J. Appl. Physiol. 88:1446-1456, 2000.
12. NHLBI Workshop summary. Respiratory muscle fatigue: report of the Respiratory Muscle Fatigue Workshop Group. Am. Rev. Respir Dis. 142:474-480, 1990.
13. Polkey, M.I., D. Kyroussis, S.E. Keilty, C.H. Hamnegard, G.H. Mills, M. Green, and J. Moxham. Exhaustive treadmill exercise does not reduce twitch transdiaphragmatic pressure in patients with COPD. Am. J. Respir. Crit. Care Med. 152:959-964, 1995.
14. Roussos, C.S., and P.T. Macklem. Diaphragmatic fatigue in man. J. Appl. Physiol. 43:189-197, 1977.
15. Roussos C.S., and M. Aubier. Neural drive and electromechanical alterations in the fatiguing diaphragm. In: Human Muscle Fatigue: Physiological Mechanisms. London: Pitman Medical, 1981 (Ciba Foundation Symposium 82), p. 213-233.