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Volumn 36, Issue 3, 2001, Pages 237-242
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Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring
a
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Author keywords
6 bromomethyl 2,4 pteridinediamine; Antifolate evaluation; Curtius rearrangement; Dihydrofolate reductase; N (4 aminobicyclo 2.2.2 octane 1 carbonyl) L glutamic acid dimethyl ester
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Indexed keywords
AMINOPTERIN;
AMINOPTERIN DERIVATIVE;
DIHYDROFOLATE REDUCTASE;
DIHYDROFOLATE REDUCTASE INHIBITOR;
FOLIC ACID ANTAGONIST;
N [4 [[(2,4 DIAMINO 6 PTERIDINYL)METHYL]AMINO]BICYCLO[2.2.2]OCTANE 1 CARBONYL]GLUTAMIC ACID;
UNCLASSIFIED DRUG;
ALKYLATION;
ANIMAL CELL;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CELL STRAIN HL 60;
CONTROLLED STUDY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
HYDROLYSIS;
LEUKEMIA L 1210;
MOUSE;
NONHUMAN;
STOICHIOMETRY;
STRUCTURE ANALYSIS;
AMINOPTERIN;
CELL DIVISION;
ENZYME INHIBITORS;
FOLIC ACID ANTAGONISTS;
HUMANS;
STRUCTURE-ACTIVITY RELATIONSHIP;
TETRAHYDROFOLATE DEHYDROGENASE;
TUMOR CELLS, CULTURED;
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EID: 0035310803
PISSN: 02235234
EISSN: None
Source Type: Journal
DOI: 10.1016/S0223-5234(01)01224-7 Document Type: Article |
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Times cited : (18)
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References (21)
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