Minimal model analyses of beta cell secretion, insulin sensitivity and glucose effectiveness in glucose tolerant, non-diabetic first-degree relatives of Ghanaian patients with type 2 diabetes and healthy control subjects

Ethnicity and Disease

Volumn 11, Issue 2, 2001, Pages 201-210

  Amoah, Albert G B ^a   Owusu, Samuel K ^a   Ayittey, Osa Mensah ^a   Schuster, Dara P ^b   Osei, Kwame ^b  

^a UNIVERSITY OF GHANA   (Ghana)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Ghanaians; Glucose Effectiveness; Insulin Sensitivity; Relatives; Type 2 Diabetes

Indexed keywords

ADULT; ARTICLE; ETHNOLOGY; FEMALE; GENETICS; GHANA; GLUCOSE TOLERANCE TEST; HUMAN; HYPERINSULINISM; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS;

ADULT; DIABETES MELLITUS, TYPE 2; FEMALE; GHANA; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; MALE;

EID: 0035288797     PISSN: 1049510X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Tattersal RB, Fajans S. Prevalence of diabetes and glucose intolerance in 199 offspring of 37 conjugal parents' diabetes. Diabetes. 1975;24:452-462.
2. Barrett AH, Eff C, Leslie RDG, Pyke DA. Diabetes in identical twins. A study of 200 pairs. Diabetologia. 1981;20:87-93.
3. Martin BC, Warram JH, Ronser B, Rich SS, Soeldner JS, Krowlewski AS. Familial clustering of insulin sensitivity. Diabetes. 1992;41:850-854.
4. Lillioja S, Mott DM, Zawadzki JK, et al. In vivo insulin action is a familial characteristic in non-diabetic Pima Indians. Diabetes. 1987;36:1329-1335.
5. Martin BC, Warram JH, Krowleski AS, Bergman RW, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a follow-up study. Lancet. 1991;340(1):925-929.
6. O'Rahilly SP, Rudenski AS, Burnett MA, Nugent Z, Hosker JP, Darling P. Beta cell dysfunction rather than insulin sensitivity is the primary defect in familial type 2 diabetes. Lancet. 1986;2:3660-3663.
7. Vaag A, Henrikson JE, Madsbad S, Holm N, Beck-Nelson. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin dependent mellitus. J Clin Invest. 1995;95:690-698.
8. DeFronzo RA, Ferrannini E, Simonson DC. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism. 1989;38:387-395.
9. Reaven GM, Bernstein R, Davis B, Olefsky JM. Nonketotic diabetes mellitus: insulin deficiency or insulin resistance. Am J Med. 1976;60:80-88.
10. Reaven GM, Hollenbeck CB, Chen Y-D. Relationship between glucose tolerance, insulin secretion, and insulin action to obese individuals with varying degrees of glucose tolerance. Diabetologia. 1989;32:52-55.
11. Sicree RA, Zimmet PZ, King HOM, Coventry JS. Plasma insulin in Nauruans: prediction of deterioration in glucose tolerance over 6 years. Diabetes. 1987;36:179-186.
12. Saad MF, Knowler WC, Pettitt DJ, Nelson RG, Mott DM, Bennett PH. Sequential changes in serum insulin concentration during development of non-insulin-dependent diabetes. Lancet. 1989; 1(113):909-915.
13. Motalal M, Omar MAK. Evidence for impaired pancreatic beta cell function in southern African Indians with impaired glucose tolerance. Diabet Med. 1994;11:437-444.
14. Davis MJ, Metcalfe J, Gray IP, Day JL, Hale CN. Insulin deficiency rather than hyperinsulinemia in newly diagnosed type 2 mellitus. Diabet Med. 1994:10:305-312.
15. Harris MI, Hadden WC, Knowler WC, Bennett PH. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in US population aged 20-74. Diabetes. 1987:36:523-524.
16. King H, Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. Diabetes Care. 1993;16:157-177.
17. King H, Aubert R, Herman WH. Global burden of diabetes, 1995. Prevalence, numerical estimates and projections. Diabetes Care. 1998; 21:1414-1433.
18. Haffner SM, Stern MP, Mithell BD, Hazuda HP, Patterson JK. Incidence of type 2 diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body fat distribution. Diabetes. 1990;39:281-288.
19. McLarty DG, Pollitt C, Swai ABM. Diabetes in Africa. Diabet Med. 1990;1(11):670-684.
20. Osterbe T, Welby TJ, Prior LAM, Salmond CE, Stokes YM. Type 2 non-insulin-dependent diabetes mellitus, migration and westernization: the Tokelau Island Study. Diabetologia. 1992;32:585-590.
21. Cooper RS, Rotimi CN, Kaufman JS, et al. Prevalence of NIDDM among populations of African Diaspora. Diabetes Care. 1997;20:343-348.
22. Mbanaya JCN, Njogang J, Salah JN, Minkoulou E, Balkau B. Prevalence of NIDDM and impaired glucose tolerance in rural and urban populations in Cameroon. Diabetologia. 1997;40:824-829.
23. Joffe BI, Panz VR, Wing JR, Rall FJ, Seftel HC. Pathogenesis of non-insulin-dependent diabetes in the Black population of southern Africa. Lancet. 1992;340:460-462.
24. Rubenstein AH, Seftel HC, Miller K, Bersohn I, Wright AD. Metabolic response to oral glucose in healthy South African White, Indian and African subjects. BMJ. 1969:748-751.
25. Ezenwaka CE, Akanji AO, Osei K, et al. Glucose and serum insulin responses to intravenous glucose challenge in relatives of Nigerian patients with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 1993;20:175-181.
26. Haffner SM, D'Agistnio R, Saad MF, et al. Increased insulin resistance and insulin secretion in non-diabetic African Americans and Hispanics compared with non-Hispanics compared with non-Hispanic Whites. The Insulin Resistance Atherosclerosis Study. Diabetes. 1996;45:742-754.
27. Osei K, Cottrell DA. Minimal model analyses of insulin sensitivity and glucose dependent glucose disposal in Black and White Americans: a study of persons at risk for type 2 diabetes. Eur J Clin Invest. 1994;24:843-850.
28. Osei K, Ezenwaka EC, Cottrell DA, Akanji AO, Adejuwon CA, O'Dorisio TM. Serum insulin and glucose concentrations in people at risk for type 2: a comparative study of African Americans and Nigerians. Diabetes Care. 1993;16:1367-1375.
29. Haffner S, Howard R, Saad P, et al. Insulin sensitivity and acute insulin responses in African Americans, non-Hispanic Whites and Hispanics and NIDDM: the insulin resistance and Atherosclerosis Study. 1997;46:63-69.
30. Osei K, Schuster DP. Metabolic characteristics of West African descendants: a comparative study of African Americans and Ghanaian immigrants using minimal model analysis. Diabetologia. 1995; 38:1103-1109.
31. Osei K, Cottrell DA, Harris B. Differences in basal and post-stimulation glucose homeostasis in non-diabetic first-degree relatives of Black and White patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 1992;75:82-86.
32. Osei K, Schuster DP. Ethnic differences in secretion, sensitivity and hepatic extraction of insulin in Black and White Americans. Diabet Med. 1994; 11:755-762.
33. Cruickshank JK, Cooper J, Burnett M, MacDuff J, Drubra U. Ethnic differences in fasting plasma c-peptide and insulin in relation to glucose tolerance and blood pressure. Lancet. 1991;11:338-342.
34. Fontbonne A, Papoz L, Eschwege E, Roger M, Saint-Paul M, Simon D. Features of insulin resistance syndrome in men from French Caribbean Islands: The Telecom Study. Diabetes. 1992;41: 1385-1389.
35. Osei K, Gaillard T, Schuster DP. Pathogenetic mechanism of impaired glucose tolerance and type II diabetes in African Americans. The significance of insulin secretion, insulin sensitivity and glucose effectiveness. Diabetes Care. 1997;20:396-404.
36. Osei K, Schuster DP. Decreased insulin-mediated but not non-insulin-dependent glucose disposal in glucose intolerance and type 2 diabetes in African (Ghanaian) immigrants. Am J Med Sci. 1996;311: 113-121.
37. Aronoff SL, Bennett PH, Goden P, Rushford M. Unexplained hyperinsulinemia in normal and pre-diabetic Pima Indians when compared with normal Caucasians: an example of racial differences in insulin secretion. Diabetes. 1977;26:827-840.
38. Leslie RDG, Ganash A, Volkma HP, Poncher MM, Hanning I, Alberti KGMM. Metabolic abnormalities in children of non-insulin-dependent patients. BMJ. 1986;293:840-842.
39. Leslie RDG, Ganash A, Volkman HP, Hanning I, Alberti KGMM. Insensitivity of insulin in offspring of non-insulin-dependent diabetic patients. Diabetes Metab. 1988;3:235-237.
40. Erickson J, Franssila Kallunki A, Ekstrand A, et al. Early metabolic defects in persons at risk for non-insulin-dependent diabetes mellitus. N Engl J Med. 1989;321:337-343.
41. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Increased insulin concentrations in non-diabetic offspring of diabetic patients. N Engl J Med. 1986;319:1297-1301.
42. World Health Organization Study Group. Diabetes mellitus: report of WHO Study Group. World Health Organ Tech Rep Ser. 1985;7727:88.
43. Segal KR, Loan MC, Fitzgerald PL, Hodgdon JA, Van Itallie TB. Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study. Am J Clin Nutr. 1988;47:4-17.
44. Bergman RN. Toward physiological understanding of glucose tolerance: minimal model approach. Diabetes. 1989;336:1512-1527.
45. Taniguchi A, Nakai Y, Fukushima M, et al. Insulin sensitivity and insulin secretion in subjects with impaired glucose tolerance: a minimal model analysis. Metabolism. 1994;43:714-718.
46. Taniguchi A, Nakai Y, Fukushima M, et al. Pathogenic factors responsible for future glucose tolerance in patients with NIDDM. Diabetes. 1992; 41:1540-1546.
47. Bergman RN, Prager R, Volund A, Olefsky J. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest. 1987;79: 790-800.
48. Kahn SE, Prager RL, McCulloch DK, et al.The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects. Diabetes. 1994;43:587-592.
49. Davies MJ, Rayman G, Grentell A, Gray IP, Hales CN. Loss of the first phase response to intravenous glucose in subjects with persistent impaired glucose tolerance. Diabet Med. 1994;11:432-436.
50. Lundgren H, Bengtsson C, Blohme G, Lapidus L, Waldenstom J. Fasting serum insulin concentration and early insulin response as risk determinants for developing diabetes. Diabetes. 1990;7: 440-443.