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Volumn 3, Issue 2, 2001, Pages 147-155

Oxaliplatin: A new agent for colorectal cancer

Author keywords

Clin Oncol; Colorectal Cancer; Irinotecan; Maximum Tolerate Dose; Oxaliplatin

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; CAMPTOTHECIN; DRUG DERIVATIVE; FLUOROURACIL; IRINOTECAN; OXALIPLATIN; PLATINUM COMPLEX;

EID: 0035286255     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-001-0015-6     Document Type: Article
Times cited : (36)

References (49)
  • 1
    • 0032585232 scopus 로고    scopus 로고
    • Randomized trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
    • PID: 9807987, COI: 1:CAS:528:DyaK1cXnsVSmsLs%3D
    • Cunningham D, Pyrhonen S, James RD, et al.: Randomized trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 1998, 352:1413–1418. DOI: 10.1016/S0140-6736(98)02309-5
    • (1998) Lancet , vol.352 , pp. 1413-1418
    • Cunningham, D.1    Pyrhonen, S.2    James, R.D.3
  • 2
    • 0032585197 scopus 로고    scopus 로고
    • Randomized trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
    • PID: 9807986, COI: 1:CAS:528:DyaK1cXnsVSmsLo%3D
    • Rougier P, Man Cutsem E, Bajetta E, et al.: Randomized trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 1998, 352:1407–1412. DOI: 10.1016/S0140-6736(98)03085-2
    • (1998) Lancet , vol.352 , pp. 1407-1412
    • Rougier, P.1    Man Cutsem, E.2    Bajetta, E.3
  • 3
    • 0000389059 scopus 로고    scopus 로고
    • Weekly irinotecan (CPT-11), leucovorin, and fluorouracil is superior to daily x 5 leucovorin + 5-FU in patients with previously untreated metastatic colorectal cancer [abstract]
    • Saltz LB, Locker PK, Pirotta N, et al.: Weekly irinotecan (CPT-11), leucovorin, and fluorouracil is superior to daily x 5 leucovorin + 5-FU in patients with previously untreated metastatic colorectal cancer [abstract]. Proc ASCO 1999, 18:233.
    • (1999) Proc ASCO , vol.18 , pp. 233
    • Saltz, L.B.1    Locker, P.K.2    Pirotta, N.3
  • 4
    • 0034712536 scopus 로고    scopus 로고
    • A randomized phase III trial comparing irinotecan + 5-FU + folinic acid to the same schedule of 5-FU+ folinic acid in patients with metastatic colorectal cancer as front line chemotherapy
    • PID: 10744089, COI: 1:CAS:528:DC%2BD3cXisFOnsb4%3D
    • Douillard JY, Cunningham D, Roth AD, et al.: A randomized phase III trial comparing irinotecan + 5-FU + folinic acid to the same schedule of 5-FU+ folinic acid in patients with metastatic colorectal cancer as front line chemotherapy. Lancet 2000, 355:1041–1047. DOI: 10.1016/S0140-6736(00)02034-1
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 5
    • 0000460127 scopus 로고    scopus 로고
    • Oxaliplatin, tetraplatin, cesplatin, and carboplatin: spectrum of activity in drugresistant cell lines and in the cell lines of the National Cancer Institute’s Anticancer Drug Screen panel
    • PID: 8951344, COI: 1:CAS:528:DyaK28XnsFChtrw%3D
    • Rixe O, Ortuzar W, Alvarez M, et al.: Oxaliplatin, tetraplatin, cesplatin, and carboplatin: spectrum of activity in drugresistant cell lines and in the cell lines of the National Cancer Institute’s Anticancer Drug Screen panel. Biochem Pharmacol 1996, 52:1855–1865. DOI: 10.1016/S0006-2952(97)81490-6
    • (1996) Biochem Pharmacol , vol.52 , pp. 1855-1865
    • Rixe, O.1    Ortuzar, W.2    Alvarez, M.3
  • 6
    • 0017386903 scopus 로고
    • Synthesis and anti-tumor activities of platinum (II) complexes of 1,2-diaminocyclo hexane isomers and their related derivatives
    • COI: 1:CAS:528:DyaE2sXktVShu7Y%3D
    • Kidani Y, Inagaki K, Saito R, et al.: Synthesis and anti-tumor activities of platinum (II) complexes of 1,2-diaminocyclo hexane isomers and their related derivatives. J Clin Hematol Oncol 1977, 7:197–209.
    • (1977) J Clin Hematol Oncol , vol.7 , pp. 197-209
    • Kidani, Y.1    Inagaki, K.2    Saito, R.3
  • 7
    • 0027522684 scopus 로고
    • Role of carrier ligand in platinum resistance of human carcinoma cell lines
    • PID: 8428361, COI: 1:CAS:528:DyaK3sXhs1Sksr0%3D
    • Schmidt W, Chaney SG: Role of carrier ligand in platinum resistance of human carcinoma cell lines. Cancer Res 1993, 53:799–805.
    • (1993) Cancer Res , vol.53 , pp. 799-805
    • Schmidt, W.1    Chaney, S.G.2
  • 8
    • 15444350120 scopus 로고    scopus 로고
    • In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair
    • PID: 9157971, COI: 1:CAS:528:DyaK2sXjtlGlt78%3D
    • Fink D, Zheng H, Nebel S, et al.: In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res 1997, 57:1841–1845.
    • (1997) Cancer Res , vol.57 , pp. 1841-1845
    • Fink, D.1    Zheng, H.2    Nebel, S.3
  • 9
    • 0031864830 scopus 로고    scopus 로고
    • Oxaliplatin: mechanism of action and antineoplastic activity
    • PID: 9609103, COI: 1:CAS:528:DyaK1cXjvVCkt70%3D, Excellent general review of mechanism of action of oxaliplatin with recent evidence for relationship to MMR cellular defects
    • Raymond E, Sandrine F, Woynarowski JM, Chaney SG: Oxaliplatin: mechanism of action and antineoplastic activity. Semin Oncol 1998, 25(suppl 5):4–15. Excellent general review of mechanism of action of oxaliplatin with recent evidence for relationship to MMR cellular defects.
    • (1998) Semin Oncol , vol.25 , pp. 4-15
    • Raymond, E.1    Sandrine, F.2    Woynarowski, J.M.3    Chaney, S.G.4
  • 10
    • 0022910291 scopus 로고
    • A phase I trial of trans-1-diaminocyclohexane oxalato-platinum (L-OHP)
    • COI: 1:STN:280:BiiB3Mvkt1E%3D
    • Mathe G, Kidani Y, Triana K, et al.: A phase I trial of trans-1-diaminocyclohexane oxalato-platinum (L-OHP). Biomed Pharmacolther 1986, 40:372–376.
    • (1986) Biomed Pharmacolther , vol.40 , pp. 372-376
    • Mathe, G.1    Kidani, Y.2    Triana, K.3
  • 11
    • 0025020085 scopus 로고
    • Phase I study of oxaliplatin in patients with advanced cancer
    • PID: 2295116, COI: 1:STN:280:By%2BC3c1U%3D
    • Extra JM, Espie M, Calvo F, et al.: Phase I study of oxaliplatin in patients with advanced cancer. Cancer Chemother Pharmacol 1990, 25:299–303. DOI: 10.1007/BF00684890
    • (1990) Cancer Chemother Pharmacol , vol.25 , pp. 299-303
    • Extra, J.M.1    Espie, M.2    Calvo, F.3
  • 12
    • 0025338285 scopus 로고
    • Phase I trial of five-day continuous venous infusion of oxaliplatin at circadian rhythm-modulated rate compared with constant rate
    • PID: 2348469, COI: 1:STN:280:By%2BB2s7is1Q%3D
    • Caussanel JP, Levi F, Brienza S, et al.: Phase I trial of five-day continuous venous infusion of oxaliplatin at circadian rhythm-modulated rate compared with constant rate. J Natl Cancer Inst 1990, 82:1046–1050. DOI: 10.1093/jnci/82.12.1046
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1046-1050
    • Caussanel, J.P.1    Levi, F.2    Brienza, S.3
  • 13
    • 0033950031 scopus 로고    scopus 로고
    • Pharmacokinetics of oxaliplatin in patients with normal versus impaired renal function
    • PID: 10663631, COI: 1:CAS:528:DC%2BD3cXmtVyrsA%3D%3D, This pharmocokinetic study was reported abstract form 1994. this recent report, the authors carefully document the dependence of oxaliplatin clearance on renal function, and the lack of associated increased toxicity patients with renal impairment
    • Massari C, Brienza S, Rotarski M, et al.: Pharmacokinetics of oxaliplatin in patients with normal versus impaired renal function. Cancer Chemother Pharmacol 2000, 45:157–164. This pharmocokinetic study was reported in abstract form in 1994. In this recent report, the authors carefully document the dependence of oxaliplatin clearance on renal function, and the lack of associated increased toxicity in patients with renal impairment. DOI: 10.1007/s002800050024
    • (2000) Cancer Chemother Pharmacol , vol.45 , pp. 157-164
    • Massari, C.1    Brienza, S.2    Rotarski, M.3
  • 14
    • 0030967259 scopus 로고    scopus 로고
    • Cumulative pharmacokinetic study of oxaliplatin, administered every three weeks, combined with 5-fluorouracil in colorectal cancer patients
    • PID: 9815764, COI: 1:CAS:528:DyaK2sXkt1Ohs7k%3D
    • Gamelin E, Le Bouil A, Boisdron-Celle M, et al.: Cumulative pharmacokinetic study of oxaliplatin, administered every three weeks, combined with 5-fluorouracil in colorectal cancer patients. Clin Cancer Res 1997, 3:891–899.
    • (1997) Clin Cancer Res , vol.3 , pp. 891-899
    • Gamelin, E.1    Le Bouil, A.2    Boisdron-Celle, M.3
  • 15
    • 0033002906 scopus 로고    scopus 로고
    • Combination of oxaliplatin plus irinotecan in patients with gastrointentinal tumors: results of two independent phase I studies with pharmacokinetics
    • PID: 10561212, COI: 1:CAS:528:DyaK1MXktV2qtLk%3D, Well-performed phase I trial with important pharmacokinetic studies
    • Wasserman E, Cuvier C, Lokiec F, et al.: Combination of oxaliplatin plus irinotecan in patients with gastrointentinal tumors: results of two independent phase I studies with pharmacokinetics. J Clin Oncol 1999, 17:1751–1759. Well-performed phase I trial with important pharmacokinetic studies.
    • (1999) J Clin Oncol , vol.17 , pp. 1751-1759
    • Wasserman, E.1    Cuvier, C.2    Lokiec, F.3
  • 16
    • 0032930471 scopus 로고    scopus 로고
    • Oxaliplatin pharmacokinetics during a four-hour infusion
    • PID: 10213210, COI: 1:CAS:528:DyaK1MXislOnsL0%3D
    • Kern W, Braess J, Böttger B, et al.: Oxaliplatin pharmacokinetics during a four-hour infusion. Clin Cancer Res 1999, 5:761–765.
    • (1999) Clin Cancer Res , vol.5 , pp. 761-765
    • Kern, W.1    Braess, J.2    Böttger, B.3
  • 17
    • 0344783805 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients
    • PID: 9704726, Carefully performed phase II study establishing the activity of oxaliplatin at a dose of 130 mg/m2 every 3 weeks. The response rate was 25% previously untreated patients, confirming oxaliplatin as one of the three most active single agents colorectal cancer
    • Bécouarn Y, Ychou M, Ducreux M, et al.: Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. J Clin Oncol 1998, 16:2739–2744. Carefully performed phase II study establishing the activity of oxaliplatin at a dose of 130 mg/m2 every 3 weeks. The response rate was 25% in previously untreated patients, confirming oxaliplatin as one of the three most active single agents in colorectal cancer.
    • (1998) J Clin Oncol , vol.16 , pp. 2739-2744
    • Bécouarn, Y.1    Ychou, M.2    Ducreux, M.3
  • 18
    • 0004700371 scopus 로고    scopus 로고
    • Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: a phase II multicentric study
    • PID: 9541691, COI: 1:STN:280:DyaK1c3gt1OksA%3D%3D, This reported study is smaller than the preceding one but is important as well because of its confirmation of the single-agent activity of oxaliplatin previously untreated patients
    • Diaz-Rubio E, Sastre J, Zaniboni A, et al.: Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: a phase II multicentric study. Ann Oncol 1998, 9:105–108. This reported study is smaller than the preceding one but is important as well because of its confirmation of the single-agent activity of oxaliplatin in previously untreated patients. DOI: 10.1023/A:1008200825886
    • (1998) Ann Oncol , vol.9 , pp. 105-108
    • Diaz-Rubio, E.1    Sastre, J.2    Zaniboni, A.3
  • 19
    • 0027310715 scopus 로고
    • Oxaliplatin activity against metastatic colorectal cancer: a phase II study of 5-day continuous venous infusion at circadian rhythm modulated rate
    • PID: 8343268
    • Lévi F, Perpoint B, Garufi C, et al.: Oxaliplatin activity against metastatic colorectal cancer: a phase II study of 5-day continuous venous infusion at circadian rhythm modulated rate. Eur J Cancer 1993, 29A:1280–1284. DOI: 10.1016/0959-8049(93)90073-O
    • (1993) Eur J Cancer , vol.29A , pp. 1280-1284
    • Lévi, F.1    Perpoint, B.2    Garufi, C.3
  • 20
    • 0012797224 scopus 로고    scopus 로고
    • Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines
    • PID: 9081400, COI: 1:STN:280:ByiD2sjgtVI%3D
    • Machover D, Diaz-Rubio E, de Gramont A, et al.: Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines. Ann Oncol 1996, 7:95–98.
    • (1996) Ann Oncol , vol.7 , pp. 95-98
    • Machover, D.1    Diaz-Rubio, E.2    de Gramont, A.3
  • 21
    • 0026512446 scopus 로고
    • A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump
    • COI: 1:STN:280:By2C3snjt10%3D
    • L’evi F, Misset J, Brienza S, et al.: A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. Cancer 1992, 69:893–900. DOI: 10.1002/1097-0142(19920215)69:4<893::AID-CNCR2820690410>3.0.CO;2-X
    • (1992) Cancer , vol.69 , pp. 893-900
    • L’evi, F.1    Misset, J.2    Brienza, S.3
  • 22
    • 10344253782 scopus 로고    scopus 로고
    • Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer
    • PID: 8918492, COI: 1:CAS:528:DyaK2sXhtVKh
    • Bertheault-Cvitkovic F, Jami A, Ithzaki M, et al.: Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer. J Clin Oncol 1996, 14:2950–2958.
    • (1996) J Clin Oncol , vol.14 , pp. 2950-2958
    • Bertheault-Cvitkovic, F.1    Jami, A.2    Ithzaki, M.3
  • 23
    • 0039276846 scopus 로고    scopus 로고
    • A multicenter evaluation of intensified, ambulatory, chronomodulated chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin as initial treatment of patients with metastatic colorectal carcinoma
    • PID: 10375099
    • Lévi F, Zidani R, Brienza S, et al.: A multicenter evaluation of intensified, ambulatory, chronomodulated chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin as initial treatment of patients with metastatic colorectal carcinoma. Cancer 1999, 85:2532–2540. DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2532::AID-CNCR7>3.0.CO;2-1
    • (1999) Cancer , vol.85 , pp. 2532-2540
    • Lévi, F.1    Zidani, R.2    Brienza, S.3
  • 24
    • 0032791959 scopus 로고    scopus 로고
    • Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery
    • PID: 10442188, COI: 1:STN:280:DyaK1MzntVOktA%3D%3D, This recent retrospective review is one of the largest series of patients undergoing hepatic resection for colorectal metastases following systemic treatment with oxaliplatin. The authors emphasize the benefits of downstaging tumors previously defined as unresectable
    • Giacchetti S, Itzhaki M, Gruia G, et al.: Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 1999, 10:663–669. This recent retrospective review is one of the largest series of patients undergoing hepatic resection for colorectal metastases following systemic treatment with oxaliplatin. The authors emphasize the benefits of downstaging tumors previously defined as unresectable. DOI: 10.1023/A:1008347829017
    • (1999) Ann Oncol , vol.10 , pp. 663-669
    • Giacchetti, S.1    Itzhaki, M.2    Gruia, G.3
  • 25
    • 0028036652 scopus 로고
    • Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial
    • PID: 7932825
    • Lévi F, Zidani R, Vannetezel J, et al.: Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial. J Natl Cancer Inst 1994, 86:1608–1617. DOI: 10.1093/jnci/86.21.1608
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1608-1617
    • Lévi, F.1    Zidani, R.2    Vannetezel, J.3
  • 26
    • 0041055512 scopus 로고    scopus 로고
    • Randomised muilticentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer
    • PID: 9291901
    • Lévi F, Zidani R, Misset J, et al.: Randomised muilticentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. Lancet 1997, 350:681–686. DOI: 10.1016/S0140-6736(97)03358-8
    • (1997) Lancet , vol.350 , pp. 681-686
    • Lévi, F.1    Zidani, R.2    Misset, J.3
  • 27
    • 0033989203 scopus 로고    scopus 로고
    • Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
    • PID: 10623704, COI: 1:CAS:528:DC%2BD3cXmtFSqsw%3D%3D, One of two randomized phase III trials used as a pivotal trial for FDA licensing. An example oncology that response rate and progressionfree survival do not always translate into significant overall survival
    • Giacchetti S, Perpoint B, Zidani R, et al.: Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 2000, 18:136–147. One of two randomized phase III trials used as a pivotal trial for FDA licensing. An example in oncology that response rate and progressionfree survival do not always translate into significant overall survival.
    • (2000) J Clin Oncol , vol.18 , pp. 136-147
    • Giacchetti, S.1    Perpoint, B.2    Zidani, R.3
  • 28
    • 0000449676 scopus 로고    scopus 로고
    • A randomized trial of leucovorin (LV) and 5-fluorouracil (5FU) with or without oxaliplatin in advanced colorectal cancer (CRC) [abstract]
    • Reported only abstract form, this study is important because it was also used for the FDA licensing application. The 5-FU regimen did not include chronomodulation and is being used as an arm current US trials
    • de Gramont A, Figer A, Seymour M, et al.: A randomized trial of leucovorin (LV) and 5-fluorouracil (5FU) with or without oxaliplatin in advanced colorectal cancer (CRC) [abstract]. Proc ASCO 1998, 17:257. Reported only in abstract form, this study is important because it was also used for the FDA licensing application. The 5-FU regimen did not include chronomodulation and is being used as an arm in current US trials.
    • (1998) Proc ASCO , vol.17 , pp. 257
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 29
    • 0031774842 scopus 로고    scopus 로고
    • Bimonthly high-dose leucovorin, 5-fluorouracil infusion and oxaliplatin (FLOFOX3) for metastatic colorectal cancer resistant to the same leucovorin and 5-fluorouracil regimen
    • PID: 9862058
    • André T, Louvet C, Raymond E, et al.: Bimonthly high-dose leucovorin, 5-fluorouracil infusion and oxaliplatin (FLOFOX3) for metastatic colorectal cancer resistant to the same leucovorin and 5-fluorouracil regimen. Ann Oncol 1998, 9:1251–1253. DOI: 10.1023/A:1008475122124
    • (1998) Ann Oncol , vol.9 , pp. 1251-1253
    • André, T.1    Louvet, C.2    Raymond, E.3
  • 30
    • 0033198085 scopus 로고    scopus 로고
    • Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6)
    • PID: 10658524, COI: 1:CAS:528:DyaK1MXls1Wjsbo%3D
    • Maindrault-Goebel F, Louvet C, André T, et al.: Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6). Eur J Cancer 1999, 35:1338–1342. DOI: 10.1016/S0959-8049(99)00149-5
    • (1999) Eur J Cancer , vol.35 , pp. 1338-1342
    • Maindrault-Goebel, F.1    Louvet, C.2    André, T.3
  • 31
    • 0032730143 scopus 로고    scopus 로고
    • Multicenter phase II study of bimonthly high-dose leucovorin, fluorouracil infusion, and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen
    • PID: 10550155
    • André T, Bensmaine M, Louvet C, et al.: Multicenter phase II study of bimonthly high-dose leucovorin, fluorouracil infusion, and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen. J Clin Oncol 1999, 17:3560–3568.
    • (1999) J Clin Oncol , vol.17 , pp. 3560-3568
    • André, T.1    Bensmaine, M.2    Louvet, C.3
  • 32
    • 0031838984 scopus 로고    scopus 로고
    • Oxaliplatin plus 5-fluorouracil: clinical experience in patients with advanced colorectal cancer
    • PID: 9609106, COI: 1:CAS:528:DyaK1cXjvVCkt7g%3D
    • Bleiberg H, de Gramont A: Oxaliplatin plus 5-fluorouracil: clinical experience in patients with advanced colorectal cancer. Semin Oncol 1998, 25(suppl 5):32–39.
    • (1998) Semin Oncol , vol.25 , pp. 32-39
    • Bleiberg, H.1    de Gramont, A.2
  • 33
    • 10344253782 scopus 로고    scopus 로고
    • Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer
    • PID: 8918492, COI: 1:CAS:528:DyaK2sXhtVKh
    • Bertheault-Cvitkovic F, Jami A, Ithzaki M, et al.: Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer. J Clin Oncol 1996, 14:2950–2958.
    • (1996) J Clin Oncol , vol.14 , pp. 2950-2958
    • Bertheault-Cvitkovic, F.1    Jami, A.2    Ithzaki, M.3
  • 34
    • 0000319510 scopus 로고
    • Intensified (every 2 weeks) chronotherapy with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (L-OHP) in previously treated patients with metastatic colorectal cancer [abstract]
    • Brienza S, Levi F, Valori VM, et al.: Intensified (every 2 weeks) chronotherapy with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (L-OHP) in previously treated patients with metastatic colorectal cancer [abstract]. Proc ASCO 1993, 12:197.
    • (1993) Proc ASCO , vol.12 , pp. 197
    • Brienza, S.1    Levi, F.2    Valori, V.M.3
  • 35
    • 0002958698 scopus 로고    scopus 로고
    • Oxaliplatin (L-OHP) and 5-fluorouracil (5-FU) synergism in advanced colorectal cancer patients [abstract]
    • Meyer V, Delva R, Gamelin E, et al.: Oxaliplatin (L-OHP) and 5-fluorouracil (5-FU) synergism in advanced colorectal cancer patients [abstract]. Eur J Cancer 1997, 33:S167. DOI: 10.1016/S0959-8049(96)00360-7
    • (1997) Eur J Cancer , vol.33 , pp. S167
    • Meyer, V.1    Delva, R.2    Gamelin, E.3
  • 36
    • 85132633991 scopus 로고    scopus 로고
    • Oxaliplatin combined with 5-FU and folinic acid (5-FU/FA) as second or third line treatment in patients with advanced colorectal cancer [abstract]
    • Gerard B, Bleiberg H, Michel J, et al.: Oxaliplatin combined with 5-FU and folinic acid (5-FU/FA) as second or third line treatment in patients with advanced colorectal cancer [abstract]. Proc ASCO 1997, 16:228.
    • (1997) Proc ASCO , vol.16 , pp. 228
    • Gerard, B.1    Bleiberg, H.2    Michel, J.3
  • 37
    • 0008468046 scopus 로고    scopus 로고
    • Oxaliplatin (L-OHP) synergistic clinical activity with 5-fluorouracil (FU) in FU-resistant colorectal cancer (CRC) patients is independent of FU + FA schedule [abstract]
    • Louvet C, Bleiberg H, Gamelin E, et al.: Oxaliplatin (L-OHP) synergistic clinical activity with 5-fluorouracil (FU) in FU-resistant colorectal cancer (CRC) patients is independent of FU + FA schedule [abstract]. Proc ASCO 1996, 15:206.
    • (1996) Proc ASCO , vol.15 , pp. 206
    • Louvet, C.1    Bleiberg, H.2    Gamelin, E.3
  • 38
    • 0342832586 scopus 로고    scopus 로고
    • Extended Access French Program (EAFP) of oxaliplatin (OXA) + 5-FU in 5-FU refractory advanced colorectal cancer (RACRC) patients
    • Bensmaine A, Marty M, de Gramont A, et al.: Extended Access French Program (EAFP) of oxaliplatin (OXA) + 5-FU in 5-FU refractory advanced colorectal cancer (RACRC) patients. Proc ASCO 1999, 18:253a.
    • (1999) Proc ASCO , vol.18 , pp. 253a
    • Bensmaine, A.1    Marty, M.2    de Gramont, A.3
  • 39
    • 0006239691 scopus 로고    scopus 로고
    • Safety profile of oxaliplatin (single agent or with 5-FU) from the large North American compassionate use experience in advanced colorectal cancer (ACC)
    • Mitchell EP, LoRusso P, Gococo K, et al.: Safety profile of oxaliplatin (single agent or with 5-FU) from the large North American compassionate use experience in advanced colorectal cancer (ACC). Proc ASCO 2000, 19:1259.
    • (2000) Proc ASCO , vol.19 , pp. 1259
    • Mitchell, E.P.1    LoRusso, P.2    Gococo, K.3
  • 40
    • 0032905667 scopus 로고    scopus 로고
    • Cellular pharmacology of the combination of the DNA topoisomerase I inhibitor SN-38 and the diaminocyclohexane platinum derivative oxaliplatin
    • PID: 10353756, COI: 1:CAS:528:DyaK1MXjslKltb4%3D
    • Zeghari-Squalli N, Raymond E, Cvitkovic E, Goldwasser F: Cellular pharmacology of the combination of the DNA topoisomerase I inhibitor SN-38 and the diaminocyclohexane platinum derivative oxaliplatin. Clin Cancer Res 1999, 5:1189–1196.
    • (1999) Clin Cancer Res , vol.5 , pp. 1189-1196
    • Zeghari-Squalli, N.1    Raymond, E.2    Cvitkovic, E.3    Goldwasser, F.4
  • 41
    • 0000232497 scopus 로고    scopus 로고
    • Oxaliplatin (L-OHP) and irinotecan (CPT-11) phase I/II studies: results in 5 FU refractory (FR) colorectal cancer (CRC) patients [abstract]
    • Wasserman E, Kalla S, Misset JL, et al.: Oxaliplatin (L-OHP) and irinotecan (CPT-11) phase I/II studies: results in 5 FU refractory (FR) colorectal cancer (CRC) patients [abstract]. Proc ASCO 2000, 19:238.
    • (2000) Proc ASCO , vol.19 , pp. 238
    • Wasserman, E.1    Kalla, S.2    Misset, J.L.3
  • 42
    • 85132636384 scopus 로고    scopus 로고
    • CPT-11/oxaliplatin (L-OHP) combination every two weeks: final results of a phase I study in advanced digestive malignancies [abstract]
    • Goldwasser F, Gross M, Tigaud JM, et al.: CPT-11/oxaliplatin (L-OHP) combination every two weeks: final results of a phase I study in advanced digestive malignancies [abstract]. Proc ASCO 1999, 18:259.
    • (1999) Proc ASCO , vol.18 , pp. 259
    • Goldwasser, F.1    Gross, M.2    Tigaud, J.M.3
  • 43
    • 0033047747 scopus 로고    scopus 로고
    • Combined irinotecan and oxaliplatin plus granulocyte colony-stimulating factor in patients with advanced fluoropyrimidine/leucovorinpretreated colorectal cancer
    • PID: 10071282, COI: 1:CAS:528:DyaK1MXhvFGgu74%3D, This represents one of the first published phase II trials of oxaliplatin combined with CPT-11
    • Scheithauer W, Kornek G, Raderer M, et al.: Combined irinotecan and oxaliplatin plus granulocyte colony-stimulating factor in patients with advanced fluoropyrimidine/leucovorinpretreated colorectal cancer. J Clin Oncol 1999, 17:902–096. This represents one of the first published phase II trials of oxaliplatin combined with CPT-11.
    • (1999) J Clin Oncol , vol.17 , pp. 096-902
    • Scheithauer, W.1    Kornek, G.2    Raderer, M.3
  • 44
    • 0003279176 scopus 로고    scopus 로고
    • Phase I trial of weekly oxaliplatin and irinotecan in previously treated patients with metastatic colorectal cancer [abstract]
    • Kemeny N, Tong W, Stockman J, et al.: Phase I trial of weekly oxaliplatin and irinotecan in previously treated patients with metastatic colorectal cancer [abstract]. Proc ASCO 2000, 19:948.
    • (2000) Proc ASCO , vol.19 , pp. 948
    • Kemeny, N.1    Tong, W.2    Stockman, J.3
  • 45
    • 85132641047 scopus 로고    scopus 로고
    • Oxaliplatin (OXA), irinotecan (CPT-11), and 4-day continuous infusion 5-fluorouracil (CIVFU) every three weeks (Q3W): A phase I study in advanced gastrointestinal tumors [abstract]
    • Lerebours F, Cottu P, Hocini H, et al.: Oxaliplatin (OXA), irinotecan (CPT-11), and 4-day continuous infusion 5-fluorouracil (CIVFU) every three weeks (Q3W): A phase I study in advanced gastrointestinal tumors [abstract]. Proc ASCO 2000, 19:1237.
    • (2000) Proc ASCO , vol.19 , pp. 1237
    • Lerebours, F.1    Cottu, P.2    Hocini, H.3
  • 46
    • 85132623455 scopus 로고    scopus 로고
    • Phase I-II study of irinotecan (CPT-11), oxaliplatin (L-OHP), leucovorin (LV) and 5-fluorouracil (5-FU) 48 hours continuous infusion (CI) in metastatic colorectal cancer patients [abstract]
    • Falcone A, Masi G, Pfanner E, et al.: Phase I-II study of irinotecan (CPT-11), oxaliplatin (L-OHP), leucovorin (LV) and 5-fluorouracil (5-FU) 48 hours continuous infusion (CI) in metastatic colorectal cancer patients [abstract]. Proc ASCO 2000, 19:1161.
    • (2000) Proc ASCO , vol.19 , pp. 1161
    • Falcone, A.1    Masi, G.2    Pfanner, E.3
  • 47
    • 0001344119 scopus 로고    scopus 로고
    • Combined irinotecan, oxaliplatin, 5-FU in patients with metastatic colorectal cancer [abstract
    • Calvo E, Gonzalez-Cao M, Cortes J, et al.: Combined irinotecan, oxaliplatin, 5-FU in patients with metastatic colorectal cancer [abstract. Proc ASCO 2000, 19:1008.
    • (2000) Proc ASCO , vol.19 , pp. 1008
    • Calvo, E.1    Gonzalez-Cao, M.2    Cortes, J.3
  • 48
    • 85132613345 scopus 로고    scopus 로고
    • Phase I study of triple combination of oxaliplatin + irinotecan +Lv5fu2 in patients with metastatic solid tumors [abstract
    • Conroy T, Seitz J, Capodano G, et al.: Phase I study of triple combination of oxaliplatin + irinotecan +Lv5fu2 in patients with metastatic solid tumors [abstract.] Proc ASCO 2000, 19:921G.
    • (2000) Proc ASCO , vol.19 , pp. 921G
    • Conroy, T.1    Seitz, J.2    Capodano, G.3
  • 49
    • 4243957836 scopus 로고    scopus 로고
    • Randomized phase II study of oxaloplatin (OX) or CPT-11 combined with bimonthly leucovorin and 5-fluorouracil (5-FU) in metastaic colorectal cancer. Preliminary report [abstract]
    • Recchia F, DeFilippis S, Rosselli M, et al.: Randomized phase II study of oxaloplatin (OX) or CPT-11 combined with bimonthly leucovorin and 5-fluorouracil (5-FU) in metastaic colorectal cancer. Preliminary report [abstract]. Proc ASCO 2000, 19:1049.
    • (2000) Proc ASCO , vol.19 , pp. 1049
    • Recchia, F.1    DeFilippis, S.2    Rosselli, M.3


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