Seasonal variation in cotyledoside concentration of Tylecodon wallichii (Harv.) Tölken subsp. wallichii sampled in a krimpsiekte-prevalent region

Onderstepoort Journal of Veterinary Research

Volumn 68, Issue 1, 2001, Pages 1-9

  Botha, C J ^a   Rundberget, T ^b   Wilkins, A L ^c   Mulders M S G ^a   Flaøyen A ^b   Van Aardt, M P ^d  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b NORWEGIAN VETERINARY INSTITUTE   (Norway)

^c UNIVERSITY OF WAIKATO   (New Zealand)

^d State Veterinarian   (South Africa)

Author keywords

Cardiac glycoside; Cotyledoside; Crassulaceae; Goat; Krimpsiekte; Sheep; Tylecodon wallichii subsp. wallichii

Indexed keywords

BUFADIENOLIDE DERIVATIVE; COTYLEDOSIDE; PLANT TOXIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; EPIDEMIC; GOAT; GOAT DISEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; NEUROMUSCULAR DISEASE; PLANT; SEASON; SHEEP; SHEEP DISEASE;

ANIMALS; BUFANOLIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE OUTBREAKS; GOAT DISEASES; GOATS; NEUROMUSCULAR DISEASES; PLANT POISONING; PLANTS, TOXIC; SEASONS; SHEEP; SHEEP DISEASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0035285868     PISSN: 00302465     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. ANDERSON, L.A.P., JOUBERT, J.P.J. PROZESKY, L., KELLERMAN, T.S., SCHULTZ, R. ANITRA, PROCOS, J & OLIVIER, PHILLIPA M. 1983.The experimental production of krimpsiekte in sheep with Tylecodon grandiflorus (Burm. f.) Toelken and some of its bufadienolides. Onderstepoort Journal of Veterinary Research, 50:301-307.
2. BOTHA, C.J., VAN DER LUGT, J.J., ERASMUS, G.L., KELLERMAN, T.S., SCHULTZ, R. ANITRA & VLEGGAAR, R. 1997. Krimpsiekte, associated with thalamic lesions, induced by the neurotoxic cardiac glycoside, cotyledoside, isolated from Tylecodon wallichii (Harv.) Toelken subsp. wallichii. Onderstepoort Journal of Veterinary Research, 64:189-194.
3. BOTHA, C.J., KELLERMAN, T.S., SCHULTZ, R. ANITRA, ERASMUS, G.L., VLEGGAAR, R. & RETIEF, E. 1998. Krimpsiekte in a sheep following a single dose of Tylecodon ventricosus (Burm. f.) Toelken and the isolation of tyledoside D from this plant species. Onderstepoort Journal of Veterinary Research, 65:17-23.
4. BOURDON, P.R. & MERCIER, M. 1969. Dosage des hétérosides cardiotoniques dans les liquides biologiques par spectrophotométrie d'absorption atomique. Annales de Biologie Clinique, 27:10-12; 651-657.
5. HENNING, M.W. 1926 Krimpsiekte. Report on Veterinary Research, Union of South Africa, 12:331-365.
6. KELLERMAN, T.S., COETZER, J.A.W. & NAUDÉ, T.W. 1988. Plant Poisonings and Mycotoxicoses of Livestock in Southern Africa. Cape Town: Oxford University Press.
7. KELLERMAN, T.S., NAUDÉ, T.W. & FOURIE, N. 1996. The distribution, diagnoses and estimated economic impact of plant poisonings and mycotoxicoses in South Africa. Onderstepoort Journal of Veterinary Research, 63:65-90.
8. LOW, A.B. & REBELO, A.G. 1998. Vegetation of South Africa, Lesotho and Swaziland. Department of Environmental Affairs and Tourism, Pretoria.
9. STEYN, D.G., 1949. Vergiftiging van mens en dier. Pretoria: J.L. van Schaik.
10. STEYN, P.S., VAN HEERDEN, F.R. & VAN WYK, A.J. 1984. The structure of cotyledoside, a novel toxic bufadienolide glycoside from Tylecodon wallichii (Harv.) Toelken. Journal of the Chemical Society, Perkin Transactions I: 965-967.
11. STEYN, P.S., VAN HEERDEN, F.R., VLEGGAAR, R. & ANDERSON, L.A.P. 1986a. Structure elucidation and absolute configuration of the tyledosides, bufadienolide glycosides from Tylecodon grandiflorus. Journal of the Chemical Society, Perkin Transactions I: 429-435.
12. STEYN, P.S., VAN HEERDEN, R. & VLEGGAAR, R. & ANDERSON, L.A.P. 1986b. Bufadienolide glycosides of the Crassulaceae. Structure and stereochemistry of orbicusides A - C, novel toxic metabolites of Cotyledon orbiculata. Journal of the Chemical Society, Perkin Transactions I: 1633-1636.
13. TÖLKEN, H.R. 1978. New taxa and new combinations in Cotyledon and allied genera. Bothialia, 12: 377-393.
14. VAHRMEIJER, J. 1981. Poisonous plants of southern Africa that cause stock losses. Cape Town: Tafelberg Uitgewers Bpk.