Analysis of sequence signature defining functional specificity and structural stability in helix-loop-helix proteins

Proteins: Structure, Function and Genetics

Volumn 42, Issue 4, 2001, Pages 471-480

  Chavali, Gayatri B ^a   Vijayalakshmi, C ^a   Salunke, Dinakar M ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Functional dimerization; HLH motif; Molecular interactions; Specificity; Transcriptional regulation

Indexed keywords

HELIX LOOP HELIX PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; DIMERIZATION; EMBRYO DEVELOPMENT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; GENES, REGULATOR; HELIX-LOOP-HELIX MOTIFS; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 0035282937     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0134(20010301)42:4<471::AID-PROT60>3.0.CO;2-P     Document Type: Article

References (26)

1. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains
2. Dimerization specificity of myogenic helix-loop-helix DNA-binding factors directed by non-conserved hydrophilic residues
3. Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides
4. Helix-loop-helix motif in GnRH associated peptide is critical for negative regulation of prolactin secretion
5. The MYOD family and myogenesis: Redundancy, networks, and thresholds
6. The four human muscle regulatory, helix-loop-helix proteins Myf3-Myf6 exhibit similar heterodimerization and DNA binding properties
7. The achaete - Scute gene complex of Drosophila melanogaster comprises four homologous genes
8. Transcriptional regulation by dimerization: Two sides to an incestuous relationship
9. Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: Prediction and rational design
10. GenBank
11. Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer
12. Crystal structure of MYOD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation
13. Unified approach to alignments and phylogenies
14. A novel computer modelling approach to the structures of small bioactive peptides. The structure of gonadotropin releasing hormone
15. PROCHECK: A program to check the stereochemical quality of protein structures
16. Structure and function of the n/HLH/Z domain of USF
17. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MYOD, and Myc proteins
18. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system
19. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
20. A natural classification of the basic helix-loop-helix class of transcription factors
21. A novel human muscle factor related to but distinct from MYOD1 induces myogenic conversion in 10T1/2 fibroblasts
22. NeuroD2 and neuroD3: Distinct expression patterns and transcriptional activation potentials within the neuroD gene family
23. Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the down syndrome chromosomal region
24. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif
25. Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system
26. Co-operativity of functional domains in the muscle-specific transcription factor Myf-5