Conjugative metabolism of 1,2-dibromoethane in mitochondria: Disruption of oxidative phosphorylation and alkylation of mitochondrial DNA

Biochemical Pharmacology

Volumn 61, Issue 5, 2001, Pages 595-603

  Thomas, Carin ^a   Will, Yvonne ^b   Schoenberg, Saundra L ^a   Sanderlin, Dawn ^a   Reed, Donald J ^b  

^a CENTRAL WASHINGTON UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

1,2 Dibromoethane; Conjugative metabolism; Glutathione; Mitochondrial DNA; Mitochondrial dysfunction; Oxidative phosphorylation; Rat liver

Indexed keywords

1,2 DIBROMOETHANE; ADENOSINE TRIPHOSPHATE; GLUTATHIONE TRANSFERASE; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; S (2 BROMOETHYL)GLUTATHIONE; S [2 (N 7 GUANYL)ETHYL]GLUTATHIONE; S,S' (1,2 ETHANEDIYL)BIS(GLUTATHIONE); SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SWELLING; CHEMICAL REACTION; CONJUGATION; CONTROLLED STUDY; DNA ADDUCT; DNA ALKYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER MITOCHONDRION; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT; RESPIRATION CONTROL;

ADENOSINE TRIPHOSPHATE; ALKYLATION; ANIMALS; DNA ADDUCTS; DNA, MITOCHONDRIAL; ENVIRONMENTAL POLLUTANTS; ETHYLENE DIBROMIDE; GLUTATHIONE; GUANINE; MALE; MITOCHONDRIA, LIVER; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035282858     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00577-3     Document Type: Article

References (32)

1. Ethylene dibromide
2. Carcinogenicity studies on halogenated hydrocarbons
3. Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane
4. Two fatalities after acute occupational exposure to ethylene dibromide
5. Macromolecular binding and metabolism of the carcinogen 1,2-dibromoethane
6. 7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA
7. 7-guanyl)ethyl]glutathione in DNA
8. In vitro dipeptide, nucleoside, and glutathione alkylation by S-(2-chloroethyl)glutathione and S-(2-chloroethyl)-L-cysteine
9. 7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane
10. 1-adenyl)ethyl]glutathione as an adduct formed in RNA and DNA from 1,2-dibromoethane
11. Alkylation of oxytocin by S-(2-chloroethyl)glutathione and characterization of adducts by tandem mass spectrometry and Edman degradation
12. Enrichment and biochemical characterization of boundary membrane contact sites from rat-liver mitochondria
13. Decrease of hepatic mitochondrial glutathione and mitochondrial injury induced by 1,2-dibromoethane in the rat in vivo: Effect of diethylmaleate pretreatment
14. Status of the mitochondrial pool of glutathione in the isolated hepatocyte
15. Biochemical mechanism of GSH depletion induced by 1,2-dibromoethane in isolated rat liver mitochondria. Evidence of a GSH conjugation process
16. Modification of hepatic vitamin E stores in vivo. III. Vitamin E depletion by 1,2-dibromoethane may be related to initial conjugation with glutathione
17. Induction of calcium efflux from isolated rat-liver mitochondria
18. Calcium- and phosphate-dependent release and loading of glutathione by liver mitochondria
19. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
20. Mitochondrial isolation from liver and kidney: Strategy, techniques, and criteria for purity
21. High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides
22. Rapid isolation of animal mitochondrial DNA by alkaline extraction
23. Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives
24. 7-guanyl)ethyl] adducts by the postulated S-(2-chloroethyl)cysteinyl and S-(2-chloroethyl)glutathionyl conjugates of 1,2-dichloroethane
25. Thioredoxin alkylation by a dihaloethane-glutathione conjugate
26. Polymorphisms of mitochondrial DNAs in Norway rats (Rattus norvegicus): Cleavage site variations and length polymorphism of restriction fragments
27. Rapid halogenated hydrocarbon toxicity in isolated hepatocytes is mediated by direct solvent effects
28. The metabolism of ethylene dibromide in the rat: The enzymic reaction with glutathione in vitro and in vivo
29. Utilization of glutathione during 1,2-dihaloethane metabolism in rat hepatocytes
30. Succinate dehydrogenase