α-spectrins are major ubiquitinated proteins in rat hippocampal neurons and components of ubiquitinated inclusions in neurodegenerative disorders

Brain Research Bulletin

Volumn 54, Issue 4, 2001, Pages 405-411

  Sangerman, José ^a   Killilea, Alison ^a   Chronister, Robert ^a   Pappolla, Miguel ^a   Goodman, Steven R ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's and Parkinson's diseases; Spectrin; Ubiquitin proteasome

Indexed keywords

FODRIN; IODINE 125; PROTEIN; PROTEIN ANTIBODY; PROTEIN SUBUNIT; SPECTRIN; UBIQUITIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CELL CULTURE; CELL INCLUSION; CELL LYSATE; CONTROLLED STUDY; DEGENERATIVE DISEASE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; NERVE CELL DEGENERATION; NEWBORN; NONHUMAN; PARKINSON DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ALZHEIMER DISEASE; ANIMALS; CELLS, CULTURED; HIPPOCAMPUS; HUMANS; NEURODEGENERATIVE DISEASES; NEURONS; PARKINSON DISEASE; RATS; SPECTRIN; UBIQUITINS;

EID: 0035279872     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(01)00426-9     Document Type: Article

References (33)

1. Ubiquitin, cellular inclusions and their role in neurodegeneration
2. Synthesis and assembly of spectrin during avian erythropoiesis; Stoichiometric assembly but unequal synthesis of α and β spectrin
3. Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities
4. Brain α-erythroid spectrin; Identification, compartmentalization, and β-spectrin associations
5. Structure of tetraubiquitin shows how multiubiquitin chains can be formed
6. Ubiquitin is conjugated to the cytoskeletal protein α-spectrin in mature erythrocytes
7. Identification of α-spectrin domains susceptible to ubiquitination
8. Changes in ubiquitin immunoreactivity in developing rat brain; A putative role for ubiquitin and ubiquitin conjugates in dendrite outgrowth and differentiation
9. Brain spectrin (240/235A); A novel astrocyte specific spectrin isoform
10. Brain spectrin; Of mice and men
11. Subcellular distribution of ubiquitin-protein conjugates in the hippocampus following transient ischemia
12. The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin I
13. Ubiquitin-dependent protein degradation
14. The short-lived MAT α2 transcriptional regulator is ubiquitinated in vivo
15. Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene
16. The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. The organization of cytoplasm at the presynaptic active zone of a central nervous system synapse
19. Ubiquitin is a component of paired helical filaments in Alzheimer's disease
20. Cyclin ubiquitination; The destructive end of mitosis
21. Characterization of a new beta spectrin gene which is predominantly expressed in brain
22. Brain spectrin (240/235) and brain spectrin 240/235E); Two distinct spectrin subtypes with different locations within mammalian neural cells
23. Brain spectrin (240/235) and brain spectrin (240/235E); Differential expression during mouse brain development
24. Synthesis, assembly, and turnover of α and β-erythroid and nonerythroid spectrins in rat hippocampal neurons
25. Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
26. Spectrin (βSpIIΣ1) is an essential component of synaptic transmission
27. Synapsin I-mediated interaction of brain spectrin with synaptic vesicles
28. Identification and characterization of βV spectrin, a mammalian ortholog of Drosophila beta H spectrin
29. A widely expressed βIII spectrin associated with Golgi and cytoplasmic vesicles
30. β-spectrin in human skeletal muscle; Tissue-specific differential processing of 3′ β-spectrin pre-mRNA generates a β-spectrin isoform with a unique carboxyl terminus
31. Spectrin subtypes in mammalian brains; An immunoelectron microscopic study
32. Localization of spectrin in mammalian brain
33. The domain of brain β-Spectrin responsible for synaptic vesicle association is essential for synaptic transmission