Utilization of reaction medium-dependent regiospecificity of Candida antarctica lipase (Novozym 435) for the synthesis of 1,3-dicapryloyl-2-docosahexaenoyl (or eicosapentaenoyl) glycerol

JAOCS, Journal of the American Oil Chemists' Society

Volumn 78, Issue 3, 2001, Pages 285-290

  Irimescu, Roxana ^a   Furihata, Kiyomi ^a   Hata, Kazuhiko ^a   Iwasaki, Yugo ^b   Yamane, Tsuneo ^b  

^a NIPPON SUISAN KAISHA LTD   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

1,3 Dicapryloyl 2 docosahexaenoyl glycerol; 1,3 dicapryloyl 2 eicosapentaenoylglycerol; Esterification; Ethanolysis; I mmobilized Candida antarctica lipase; Immobilized Rhizomucor mienei lipase; Regiospecificity of lipases; Transesterification

Indexed keywords

CATALYSTS; COMPOSITION; ENZYMES; ESTERIFICATION; GLYCEROL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MIXTURES; SUBSTRATES; SYNTHESIS (CHEMICAL);

CANDIDA ANTARTICA; DICAPRYLOYL DOCOSAHEXAENOYL GLYCEROL; DICAPRYLOYL EICOSAPENTAENOYLGLYCEROL; ETHANOLYSIS; LIPASE; REGIOSPECIFICITY; RHIZOMUCOR MIEHEI; TRANSESTERIFICATION;

ENZYME IMMOBILIZATION;

EID: 0035269729     PISSN: 0003021X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11746-001-0258-3     Document Type: Article

References (15)

1. Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope-labeled oleic, linoleic, and linolenic acids by male subjects
2. Polyunsaturated fatty acids, Part 1: Occurrence, biological activities and applications
3. Oxidation of synthetic triacylglycerols containing eicosapentaenoic and docosahexaenoic acids: Effect of oxidation system and triacylglycerol structure
4. Fat emulsions based on structured lipids (1,3-specific triglycerides): An investigation of the in vivo fate
5. Intestinal absorption and lymphatic transport of eicosapentaenoic (EPA), docosahexaenoic (DHA), and decanoic acids: Dependence on intramolecular triacylglycerol structure
6. Production of structured lipid containing docosahexaenoic and caprylic acids using immobilized Rhizopus delemar lipase
7. Enzymatic synthesis of structured lipids from single cell oil of high docosahexaenoic acid
8. Optimization of the reaction conditions in the lipase-catalyzed synthesis of structured glycerides
9. Use of isopropanol as a modifier in a hexane-acetonitrile based mobile phase for the silver ion HPLC separation of positional isomers of triacylglycerols containing long-chain polyunsaturated fatty acids
10. Enzymatic synthesis of structured lipids
11. Enzymatic synthesis of 1,3-dicapryloyl-2-eicosapentaenoylglycerol
12. The synthesis of homogenous triglycerides of eicosapentaenoic acid and docosahexaenoic acid by lipase
13. Preparation of highly purified concentrates of eicosapentaenoic acid and docosahexaenoic acid
14. The preparation of concentrates of eicosapentaenoic acid and docosahexaenoic acid by lipase-catalyzed transesterification of fish oil with ethanol
15. Comparison of lipase-catalyzed acidolysis and interesterification for synthesis of 1,3-Dicapryloyl-2-eicosapentaenoylglycerol