Pathophysiology of primary headaches

Current Pain and Headache Reports

Volumn 5, Issue 1, 2001, Pages 71-78

  Edvinsson, Lars ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cluster Headache; Migraine; Migraine Attack; Sumatriptan; Trigeminal Neuralgia

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CALCIUM CHANNEL; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADRENERGIC SYSTEM; BLOOD VESSEL; BRAIN CIRCULATION; CLUSTER HEADACHE; HEADACHE; HUMAN; INNERVATION; METABOLISM; MIGRAINE; PATHOPHYSIOLOGY; REVIEW; TRIGEMINUS NEURALGIA; VASCULAR HEADACHE;

BLOOD VESSELS; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM CHANNELS; CEREBROVASCULAR CIRCULATION; CLUSTER HEADACHE; HEADACHE; HUMANS; MIGRAINE DISORDERS; SYMPATHETIC NERVOUS SYSTEM; TRIGEMINAL NEURALGIA; VASCULAR HEADACHES; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0035260417     PISSN: 15313433     EISSN: 15343081     Source Type: Journal    
DOI: 10.1007/s11916-001-0013-2     Document Type: Article

References (34)

1. Willis T, ed: Cerebri Anatome. London: Martin Allestry; 1664.
2. Liveing E, ed: On Migraine, Sick-Headache, and Some Allied Disorders: A Contribution To the Pathology of Nerve Storms. London: Churchill; 1873:1–512.
3. Ray BS, Wolff HG: Experimental studies on headaches, pain sensitive structures of the head and their significance in headaches. Arch Surg 1940, 41:813–856.
4. Radner S: Intracranial angiography via the vertebral artery. Acta Radiol 1947, 28:838–843. DOI: 10.3109/00016924709138027
5. Hauge T: Catheter vertebral angiography. Acta Radiol 1954, 109:1–219.
6. Olesen J, Iversen HK, Thomsen LL: Nitric oxide supersensitivity. A possible molecular mechanisms of migraine pain. Neuroreport 1993, 4:1027–1030. DOI: 10.1097/00001756-199308000-00008
7. Fanciullacci M, Alessandri M, Figini M, et al.: Increases in plasma calcitonin gene-related peptide from extracerebral circulation during nitroglycerin-induced cluster attack. Pain 1995, 60:119–123. DOI: 10.1016/0304-3959(94)00097-X
8. Edvinsson L, Owman C, Sjöberg N-O: Autonomic nerves, mast cells and amine receptors in human brain vessles. A histochemical and pharmacological study. Brain Res 1976, 115:337–393. DOI: 10.1016/0006-8993(76)90356-5
9. Edvinsson L, MacKenzie ET, McCulloch J, eds: Cerebral Blood Flow and Metabolism. New York: Raven Press; 1993:1–683.
10. Goadsby PJ, Zagami AS: Stimulation of the superior sagittal sinus increases metabolic activity and blood flow in certain regions of the brainstem and upper cervical spinal cord of the cat. Brain 1991, 114:1001–1004. DOI: 10.1093/brain/114.2.1001
11. McCulloch J, Uddman R, Kingman TA, Edvinsson L: Calcitonin gene-related peptide. Functional role in cerebrovascular regulation. Proc Nat Acad Sci U S A 1986, 83:5731–5735. DOI: 10.1073/pnas.83.15.5731
12. Edvinsson L, McCulloch J, Kingman TA, Uddman R: On the functional role of the trigemino-cerebrovascular system in the regulation of cerebral circulation. In Neural Regulations of the Cerebral Circulation. Edited by Owman C, Hardebo JE. Amsterdam: Elsevier; 1986:407–418.
13. Goadsby PJ, Lambert GA, Lance JW: Stimulation of the trigeminal ganglion increases flow in the extra cerebral but not the cerebral circulation of the monkey. Brain Res 1986, 381:63–67. DOI: 10.1016/0006-8993(86)90690-6
14. Tran-Dinh YR, Thurei C, Cunin G, et al.: Cerebral vasodilation after the thermocoagulation of the trigeminal ganglion in humans. Neurosurgery 1992, 31:658–662. DOI: 10.1097/00006123-199207000-00019
15. Goadsby PJ, Edvinsson L, Ekman R: Vasoactive peptide release in the extracerebral circulation of human during migraine headache. Ann Neurol 1990, 28:183–197. DOI: 10.1002/ana.410280213
16. Edvinsson L, Hara H, Uddman R: Retrograde tracing of nerve fibers to the rat middle cerebral artery with True Blue: localization with different peptides. J Cereb Blood Flow Metab 1989, 9:212–218.
17. Gallai V, Sarchielli P, Floridi A, et al.: Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally. Cephalalgia 1995, 15:384–390. DOI: 10.1046/j.1468-2982.1995.1505384.x
18. Goadsby PJ, Edvinsson L: The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 1993, 33:48–56. DOI: 10.1002/ana.410330109
19. Goadsby PJ, Edvinsson L: Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain 1994, 117:427–434. DOI: 10.1093/brain/117.3.427
20. Goadsby PJ, Edvinsson L, Ekman R: Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol 1988, 23:193–196. DOI: 10.1002/ana.410230214
21. Goadsby PJ, Edvinsson L, Ekman R: Cutaneous sensory stimulation leading to facial flushing and release of calcitonin gene-related peptide. Cephalalgia 1992, 12:53–56. DOI: 10.1046/j.1468-2982.1992.1201053.x
22. Goadsby PJ, Edvinsson L: Neuropeptide changes in a case of chronic paroxysmal hemicrania: evidence for trigeminoparasympathetic activation. Cephalalgia 1996, 16:448–450. DOI: 10.1046/j.1468-2982.1996.1606448.x
23. Goadsby PJ, Edvinsson L: Peripheral and central trigeminovascular activation in cat is blocked by the serotonin (HT)-ID receptor agonist 311C90. Headache 1994, 34:394–399. DOI: 10.1111/j.1526-4610.1994.hed3407394.x
24. Martin GR: Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5-HT 1B/1D agonist for migraine. Cephalalgia 1997, 17(suppl 18):4–14.
25. Ophoff RA, Terwindt GM, Vergouve MN, et al.: Familial hemiplegic migraine and episodic ataxia type 2 are caused by mutation in the Ca2+ channel gene CACNL1A4. Cell 1996, 87:543–552. DOI: 10.1016/S0092-8674(00)81373-2
26. Weiller C, May A, Limmroth V, et al.: Brain stem activation in spontaneous human migraine attacks. Nat Med 1995, 1:658–660. DOI: 10.1038/nm0795-658
27. Olesen J, Friberg L, Skyhöj OT: Timing and topography of cerebral blood flow, aura and headache during migraine attacks. Ann Neurol 1990, 28:791–798. DOI: 10.1002/ana.410280610
28. Woods RP, Iacoboni M, Mazziotta JC: Bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. New Engl J Med 1994, 31:1689–1692. DOI: 10.1056/NEJM199412223312505
29. Edvinsson L, Degueurce A, Duverger D, et al.: Central serotonergic nerves project to the pial vessels of the brain. Nature 1983, 306:55–57. DOI: 10.1038/306055a0
30. Reinhard JF Jr, Liebmann JR, Schlosberg AJ, Moskowits MA: Serotonin neurons project to small blood vessels in the brain. Science 1979, 206:85–87. DOI: 10.1126/science.482930
31. Lauritzen M: Pathophysiology of migraine aura: the spreading depression theory. Brain 1994, 117:199–210. DOI: 10.1093/brain/117.1.199
32. May A, Bahra A, Büchel C, et al.: Hypothalamic activation in cluster headache attacks. Lancet 1998, 351:275–278. Recent demonstration that in cluster headache there is activation of the hypothalamic center, putatively linked with symptomatology. DOI: 10.1016/S0140-6736(98)02470-2
33. May A, Kaube H, Buechel C, et al.: Experimental cranial pain elicited by capsaicin: a PET study. Pain 1998, 74:61–66. DOI: 10.1016/S0304-3959(97)00144-9
34. Edvinsson L, Goadsby PJ: Neuropeptides in headache. Eur J Neurol 1998, 5:329–341. A convenient review providing a wealth of information of the neuropeptides in headache. DOI: 10.1046/j.1468-1331.1998.540329.x