Interleukin-4 variant (BAY 36-1677) selectively induces apoptosis in acute lymphoblastic leukemia cells

Blood

Volumn 97, Issue 3, 2001, Pages 752-758

  Srivannaboon, Kleebsabai ^b   Shanafelt, Armen B ^b   Todisco, Elisabetta ^b   Forte, Carla P ^b   Behm, Frederick G ^b   Raimondi, Susana C ^b   Pui, Ching Hon ^b   Campana, Dario ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BAY 36 1677; INTERLEUKIN 4; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; DRUG EFFECT; ENDOTHELIUM CELL; FIBROBLAST; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN VARIANT; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE ACTIVATION;

EID: 0035253868     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.3.752     Document Type: Article

References (41)

1. Drug therapy: Acute lymphoblastic leukemia
2. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia
3. Potential long-term toxic effects in children treated for acute lymphoblastic leukemia
4. Acute myeloid leukemia in children treated with epi-podophyllotoxins for acute lymphoblastic leukemia
5. L-asparaginase may potentiate the leukemogenic effect of the epi-podophyllotoxins
6. Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood
7. Cranial irradiation is the major cause of learning problems in children treated for leukemia and lymphoma: A comparative study
8. Identification of a T cell-derived B cell growth factor distinct from interleukin 2
9. Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation
10. Inhibitory effect of interleukin-4 on the in vitro growth of Phi-positive acute lymphoblastic leukemia cells
11. Interleukin 4 inhibits in vitro proliferation of leukemic and normal human B cell precursors
12. Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia
13. Interleukin-4 enhances the survival of severe combined immunodeficient mice engrafted with human B-cell precursor leukemia
14. Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy
15. Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections - A phase I dose toxicity trial
16. Recombinant human interleukin-4 (rhu IL-4) administered by the intravenous and subcutaneous routes in patients with advanced cancer - A phase I toxicity study and pharmacokinetic analysis
17. Phase II studies of recombinant human interleukin-4 in advanced renal cancer and malignant melanoma
18. Interleukin-4 and cancer therapy
19. Safety evaluation of recombinant human interleukin-4. II: Clinical studies
20. Interleukin-4: A prototypic immunoregulatory lymphokine
21. The IL-4 receptor: Signaling mechanisms and biologic functions
22. An immune cell-selective interleukin 4 agonist
23. Rapid and efficient site-specific mutagenesis without phenotypic selection
24. CD38 ligation inhibits normal and leukemic myelopoiesis
25. Ligation of CD38 suppresses human B lymphopoiesis
26. Stroma-supported Culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome
27. Prevalence and growth characteristics of malignant stem cells in B-lineage acute lymphoblastic leukemia
28. Cyclosporin A induces apoptosis in childhood acute lymphoblastic leukemia cells
29. In vitro cytotoxicity of docetaxel in childhood acute leukemias
30. Hyperdiploid acute lymphoblastic leukemia with 51 to 65 chromosomes: A distinct biological entity with a marked propensity to undergo apoptosis
31. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining
32. Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)
33. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
34. Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia
35. Interleukin-13 inhibits the proliferation of normal and leukemic human B-cell precursors
36. Biological activity of IL-4 and IL-13 on human endothelial cells: Functional evidence that both cytokines act through the same receptor
37. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4
38. IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts
39. Bone marrow stromal cell regulation of B lymphopoiesis: Interleukin-1 (IL-1) and IL-4 regulate stromat cell support of pre-B cell production in vitro
40. IRS-1: Essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells
41. Human interleukin-4 and variant R88Q: Phasing x-ray diffraction data by molecular replacement using x-ray and nuclear magnetic resonance models