Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells

International Journal of Pharmaceutics

Volumn 213, Issue 1-2, 2001, Pages 135-142

  Raiman, Johanna ^a,b   Niemi, Riku ^a   Vepsäläinen, Jouko ^a   Yritys, Kirsi ^a   Järvinen, Tomi ^a   Mönkkönen, Jukka ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Bisphosphonates; Caco 2 cells; Clodronate

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CALCIUM CHELATING AGENT; CLODRONIC ACID; CLODRONIC ACID DIPHENYL ESTER; CLODRONIC ACID PHENYL ESTER; CLODRONIC ACID TRIPHENYL ESTER; ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; ESTERIFICATION; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; LIPOPHILICITY; MOLECULAR WEIGHT; PRIORITY JOURNAL;

ANALGESICS, NON-NARCOTIC; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CALCIUM; CHEMISTRY, PHYSICAL; CLODRONIC ACID; HUMANS; INTESTINAL ABSORPTION; LIPIDS; MOLECULAR WEIGHT; TETRAZOLIUM SALTS; THIAZOLES;

EID: 0035253522     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00655-4     Document Type: Article

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