The Rad51 and Dmc1 recombinases: A non-identical twin relationship

Trends in Biochemical Sciences

Volumn 26, Issue 2, 2001, Pages 131-136

  Masson, Jean Yves ^a   West, Stephen C ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA;

CELL SURVIVAL; DNA REPAIR; DNA STRAND BREAKAGE; ESCHERICHIA COLI; GENETIC RECOMBINATION; GENOME; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CELL CYCLE PROTEINS; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; ESCHERICHIA COLI; HUMANS; MEIOSIS; MODELS, GENETIC; RAD51 RECOMBINASE; RECOMBINATION, GENETIC;

ESCHERICHIA COLI;

EID: 0035252918     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01742-4     Document Type: Review

References (49)

1. Recombination at work for meiosis
2. Biochemistry of homologous recombination in Escherichia coli
3. Recognition of duplex DNA containing single-stranded regions by RecA protein
4. Characterization of complexes between RecA protein and duplex DNA by electron microscopy
5. Processing of recombination intermediates by the RuvABC proteins
6. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
7. Semidominant suppressors of srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to prokaryotic RecA proteins
8. A mutation in mouse RAD51 results in an early embryonic lethal that is suppressed by a mutation in p53
9. Rad51 deficient vertebrate cells accumulate chromosomal breaks prior to cell death
10. Roles for two RecA homologs in promoting meiotic chromosome synapsis
11. Distribution of Rad51 recombinase in human and mouse spermatocytes
12. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes
13. Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage
14. Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage
15. Dynamic changes of Brca1 subnuclear location and phosphorylation state are initiated by DNA damage
16. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
17. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation
18. Purification and characterisation of the human Rad51 protein, an analogue of E. coli RecA
19. Similarity of the yeast Rad51 filament to the bacterial RecA filament
20. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro
21. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast Rad51 protein
22. Synergistic actions of Rad51 and Rad52 in genetic recombination and DNA repair
23. Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein-A
24. Stimulation by Rad52 of yeast Rad51-mediated recombination
25. Function of yeast Rad52 protein as a mediator between replication protein-A and the Rad51 recombinase
26. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins
27. Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation
28. Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament
29. Superhelicity-driven homologous DNA pairing by yeast recombination factors Rad51 and Rad54
30. A single-stranded DNA-binding protein is needed for efficient complex formation by the Saccharomyces cerevisiae Rad51 protein
31. Heteroduplex formation by human Rad51 protein: Effects of DNA end-structure, hRP-A and hRad52
32. Meiotic chromosomes: It takes two to tango
33. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
34. DMC1: A meiosis-specific yeast homolog of E. coli RecA required for recombination, synaptonemal complex formation, and cell cycle progression
35. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog
36. The mouse recA-like gene DMC1 is required for homologous chromosome synapsis during meiosis
37. Recombination activities of HsDmc1 protein the meiotic human homolog of RecA protein
38. The meiosis-specific recombinase hDmc1 forms rings structures and interacts with hRad51
39. Human Dmc1 protein binds DNA as an octameric ring
40. Dmc1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the Rad51 pathway
41. Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homolog of RAD54, RDH54/TID1, in mitosis and meiosis
42. RDH54, a RAD54 homolog in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis
43. RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis
44. Rad51 and Dmc1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes
45. Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination
46. RecA-like proteins are components of early meiotic nodules in lily
47. Tid1/Rdh54 promotes colocalization of Rad51 and Dmc1 during meiotic recombination
48. Interhomolog bias during meiotic recombination: Meiotic functions promote a highly differentiated interhomolog only pathway
49. A surfeit of RAD51-like genes?