Viral dynamics and anti-viral pharmacodynamics: Rethinking in vitro measures of drug potency

Trends in Pharmacological Sciences

Volumn 22, Issue 2, 2001, Pages 97-100

  Ferguson, Neil M ^a   Fraser, Christophe ^a   Anderson, Roy M ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PROTEINASE INHIBITOR;

ASSAY; DRUG POTENCY; DRUG POTENTIATION; IN VITRO STUDY; PHARMACODYNAMICS; PRIORITY JOURNAL; REVIEW; VIRUS INFECTION; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; HUMANS; VIRUS DISEASES; VIRUS REPLICATION; VIRUSES;

EID: 0035252382     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01615-1     Document Type: Review

References (12)

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2. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
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5. Persistence of HIV-1 transcription in peripheral blood mononuclear cells in patients receiving potent antiretroviral therapy
6. Treatment with indinavir, zidovudine and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
7. Alternative multidrug regimen provides improved suppression of HIV-1 replication over triple therapy
8. Human serum attenuates the activity of protease inhibitors toward wild-type and mutant HIV
9. The search for synergy: A critical review from a response surface perspective
10. Synergistic drug-interactions of an HIV-1 protease inhibitor with AZT in different in-vitro models of HIV-1 infection
11. Antagonism between human immunodeficiency virus type 1 protease inhibitors indinavir and saquinavir in vitro