Mu- and delta-opioid receptors are downregulated in the largest diameter primary sensory neurons during postnatal development in rats

Pain

Volumn 90, Issue 1-2, 2001, Pages 143-150

  Beland, Barbara ^a   Fitzgerald, Maria ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Dorsal root ganglion; Morphine; Neonate; Opioid receptor; Paediatric pain; Primary sensory neuron

Indexed keywords

DELTA OPIATE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR;

ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; IMMUNOREACTIVITY; LUMBAR SPINAL CORD; MALE; NEUROFILAMENT; NEWBORN; NOCICEPTIVE STIMULATION; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SENSORY NERVE; SPINAL GANGLION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CELL SIZE; DOWN-REGULATION; FEMALE; GANGLIA, SPINAL; LUMBOSACRAL REGION; MALE; NEURONS, AFFERENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 0035252360     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00397-3     Document Type: Article

References (38)

1. Axotomy reduces the effect of analgesic opioids yet increases the effect of nociception on dorsal root ganglion neurons
2. Delta-opioid receptor immunoreactivity: Distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin
3. Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord
4. Pre- and postnatal development of opiate receptor subtypes in rat spinal cord
5. Pre- and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord
6. Infant and neonatal pain: Anaesthetists' perceptions and prescribing pattern
7. Where and how do opioids act?
8. Opioid receptor subtypes in the rat spinal cord: Electrophysiological studies with μ- and δ-opioid receptor agonists in the control of nociception
9. Depression of A and C fibre-evoked segmental reflexes by morphine and clonidine in the in vitro spinal cord of the neonatal rat
10. Neonatal pharmacology of pain
11. The developmental neurobiology of pain
12. The postnatal development of spinal sensory processing
13. The functional development of descending inhibitory pathways in the dorsolateral funiculus of the newborn rat spinal cord
14. Quantification without pontification: Choosing a method for counting objects in sectioned tissues
15. Expression of mu-, delta-, and kappa-opioid receptor like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation
16. G-protein-coupled receptor heterodimerization modulates receptor function
17. Neuropeptide receptors in developing and adult rat spinal cord: An in vitro quantitative audioradiography study of calcitonin gene-related peptide, neurokinins, μ-opioid, galanin, somatostatin, neurotensin and vasoactive intestinal polypeptide receptors
18. Soma neurofilament immunoreactivity is related to cell size and fiber conduction velocity in rat primary neurones
19. Development of rat dorsal root ganglion neurones
20. Retrograde tracers for light and electron microscopy
21. Opioid systems and the newborn
22. Epidural opioid analgesia in infant rats I: Mechanical and heat responses
23. Development of opioid systems: Peptides, receptors and pharmacology
24. A comparison of the antinociceptive effects of opioid agonists in neonatal and adult rats in phasic and tonic nociceptive tests
25. Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachkinin A mRNA in the rat dorsal root ganglia
26. The use of opioids in neonates. A retrospective study of 933 cases
27. Electrophysiological studies on the postnatal development of the spinal antinociceptive effects of the delta opioid receptor agonist DPDPE in the rat
28. Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia
29. Mu opioid receptors in developing human spinal cord
30. Evidence for delta-opioid binding and GTP-regulatory proteins in 5-day-old rat brain membranes
31. Selective opioid inhibition of small nociceptive neurons
32. Ontogeny of mu opioid agonist antinociception in postnatal rats
33. Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias
34. Increased sensitivity to mu opiate antinociception in the neonatal rat despite weaker receptor-guanyl nucleotide binding protein coupling
35. Ontogeny of pharmacology and receptors: High and low affinity site differences
36. Effects of neurotoxins and hindpaw inflammation on opioid receptor immunoreactivities in dorsal root ganglia
37. Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: Evidence for association with the membrane of large dense-core vesicles
38. Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse