ProC Global: An automated screening test for Factor V Leiden and prothrombin mutation 20210 G to A detection [2]

Thrombosis Research

Volumn 101, Issue 3, 2001, Pages 215-216

  Sillero, Pilar Llamas ^a   Fernandez De Velasco J ^a   Loscertales, J ^a   Espinoza, J ^a   Soto, C ^a   Tomas J F ^a  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5 LEIDEN; PROTEIN C; PROTHROMBIN;

ADOLESCENT; ADULT; AGED; BLOOD CLOTTING FACTOR 5 DEFICIENCY; COLORIMETRY; CONTROLLED STUDY; DIAGNOSTIC TEST; ELECTROPHORESIS; FEMALE; GENE MUTATION; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; THROMBOPHILIA;

FACTOR V; GENETIC SCREENING; HUMANS; MUTATION; PREDICTIVE VALUE OF TESTS; PROTHROMBIN;

EID: 0035251865     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00375-3     Document Type: Letter

References (5)

1. Evaluation of a new screening assay ProC Global for identification of defects in the protein C/protein S anticoagulant pathway
2. Laboratory screening of thrombophilia. Evaluation of the diagnostic efficacy of a global test to detect congenital deficiencies of the protein C anticoagulant pathway
3. A common genetic variation in the 3′-untranslated region of prothrombin gene is associated with elevated plasma prothrombin levels and increase in venous thrombosis
4. Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis
5. Familial thrombophilia due to a previously unrecognised mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C