Versican modulates embryonic chondrocyte morphology via the epidermal growth factor-like motifs in G3

Experimental Cell Research

Volumn 263, Issue 1, 2001, Pages 33-42

  Zhang, Y ^a   Wu, Y ^a   Cao, L ^a   Lee, V ^a   Chen, L ^a   Lin, Z ^a   Kiani, C ^a   Adams, M E ^a   Yang, B B ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Actin; CBP; CRD; G3 domain; Proteoglycan

Indexed keywords

ACTIN; ANTISENSE OLIGONUCLEOTIDE; EPIDERMAL GROWTH FACTOR; PROTEOGLYCAN; VERSICAN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL STRUCTURE; CHICK EMBRYO; CONTROLLED STUDY; CYTOSKELETON; EMBRYO; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF;

GALLUS GALLUS; STERNA;

EID: 0035242502     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5095     Document Type: Article

References (42)

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3. Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter
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7. Regulation of development and differentiation by the extracellular matrix
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9. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
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13. The occurrence of a new type of proteochondroitin sulfate in the developing chick embryo
14. Chemical and physical changes in proteoglycans during development of chick limb bud chondrocytes grown in vitro
15. Morphological and biochemical differentiation of limb bud cells cultured in chemically defined medium
16. Physical and immunochemical characterization of proteoglycans synthesized during chondrogenesis in the chick embryo
17. Tissue variation of two large chondroitin sulfate proteoglycans (PG-M/versican and PG-H/aggrecan) in chick embryos
18. Independent deposition of collagen types II and IX at epithelial-mesenchymal interfaces
19. Chondroitin sulfate proteoglycan (PG-M-like proteoglycan) is involved in the binding of hyaluronic acid to cellular fibronectin
20. Regulation of cell-substrate adhesion by proteoglycans immobilized on extracellular substrates
21. The versican C-type lectin domain recognizes the adhesion protein tenascin-R
22. The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety
23. A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences
24. Promotion of chondrocyte proliferation by versican mediated by G1 domain and EGF-like motifs
25. Tandem repeats are involved in G1 domain inhibition of versican expression and secretion and the G3 domain enhances glycosaminoglycan modification and secretion via the complement-binding protein motif
26. Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid
27. Chondrocyte apoptosis induced by aggrecan G1 domain as a result of decreased cell adhesion
28. beta-Integrin-collagen interaction reduces chondrocyte apoptosis
29. The G3 domain of versican inhibits mesenchymal chondrogenesis via the epidermal growth factor-like motifs
30. In vitro differentiation potential of the periosteal cells from a membrane bone, the quadratojugal of the embryonic chick
31. The G3 domain of versican enhances cell proliferation via EGF-like motifs
32. Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the dermis
33. Versican gene expression in human articular cartilage and comparison of mRNA splicing variation with aggrecan
34. Abnormal occurrence of a large chondroitin sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage
35. Aggrecan and link protein affect cell adhesion to culture plates and to type II collagen
36. Aggrecan synthesized by mature bovine chondrocytes suspended in alginate. Identification of two distinct metabolic matrix pools
37. Synergistic action of transforming growth factor-beta and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytes
38. Compressive force promotes sox9, type II collagen and aggrecan and inhibits IL-1beta expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells
39. Isolated chondrons: A viable alternative for studies of chondrocyte metabolism in vitro
40. Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes in vitro
41. Distribution of targets for avian retrovirus DNA integration in vivo
42. Insertional mutagenesis and marker rescue in a protozoan parasite: Cloning of the uracil phosphoribosyltransferase locus from Toxoplasma gondii