COX-2-specific inhibitors: Definition of a new therapeutic concept

American Journal of Therapeutics

Volumn 8, Issue 1, 2001, Pages 49-64

  Verburg, Kenneth M ^a   Maziasz, Timothy J ^a   Weiner, Ethan ^a   Loose, Leland ^a   Isakson, Peter C ^a  

^a Clinical Research and Development A3E   (United States)

Author keywords

Anti inflammatory; Clinical assessments; Cox 2 specific inhibitors; Cyclooxygenase; Gastrointestinal toxicity

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ISOENZYME; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN;

DIGESTIVE SYSTEM; DRUG ANTAGONISM; DRUG EFFECT; HEMOSTASIS; HUMAN; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVIEW; RHEUMATOID ARTHRITIS; THROMBOCYTE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; BLOOD PLATELETS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DIGESTIVE SYSTEM; HEMOSTASIS; HUMANS; INTESTINAL MUCOSA; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS;

EID: 0035235121     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-200101000-00009     Document Type: Article

References (3)

1. Allison MC, Howatson AG, Torrance CJ, et al: Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N Engl J Med 1992;327:749-754.
2. Rodriguez LAG, Cattaruzzi C, Troncon M, et al: Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal antiinflammatory drugs, calcium antagonists, and other antihypertensive drugs. Arch Intern Med 1998;158:35-39.
3. Garciá-Rodríguez LA, Jick H: Risk of upper gastrointestinal bleeding and perforation associated with nonsteroidal anti-inflammatory drugs. The Lancet 1994;343:769-772.