Effect of M2 and M3 Muscarinic receptors on airway responsiveness to carbachol in bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) Guinea pigs

Experimental Animals

Volumn 50, Issue 1, 2001, Pages 49-58

  Kadota, Hiromi ^a   Kuwahara, Masayoshi ^a   Nishibata, Ryoji ^b   Mikami, Hiroki ^b   Tsubone, Hirokazu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Nippon Zoki Pharmaceutical Co   (Japan)

Author keywords

Airway smooth muscle; Carbachol; mRNA; Muscarinic receptor subtypes

Indexed keywords

CAVIA;

4 DIPHENYLACETOXY 1,1 DIMETHYLPIPERIDINIUM; 4-DIPHENYLACETOXY-1,1-DIMETHYLPIPERIDINIUM; CARBACHOL; DIAMINE; MESSENGER RNA; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PIPERIDINE DERIVATIVE;

ANIMAL; ARTICLE; BRONCHUS HYPERREACTIVITY; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION; GENETICS; GUINEA PIG; LUNG; MALE; MUSCLE CONTRACTION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE; TRACHEA;

ANIMALS; BRONCHIAL HYPERREACTIVITY; CARBACHOL; DIAMINES; GENE EXPRESSION; GUINEA PIGS; LUNG; MALE; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERIDINES; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRACHEA;

EID: 0035230335     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.50.49     Document Type: Article

References (33)

1. Barnes, P.J. 1993. Muscarinic receptor subtypes in airways. Life Sci. 52: 521-527.
2. Birumachi, J., Maeda, M., Kuwahara, M., Sugano, S., Nishibata, R., Mikami, H., and Tsubone, H. 1998. Histamine-induced airway contraction in congenitally bronchial hypersensitive (BHS) and bronchial hyposensitive (BHR) guinea pigs. Exp. Anim. 47: 55-62.
3. Bonner, T.I., Buckley, N.J., Young, A.C., and Brann, M.R. 1987. Identification of a family of muscarinic acetylcholine receptor genes. Science 237: 527-532.
4. D'Agostino, G., Chiari, M. C., Grana, E., Subissi, A., and Kilbinger, H. 1990. Muscarinic inhibition of acetylcholine release from a novel in vitro preparation of the guinea-pig trachea. Naunyn Schmiedebergs Arch. Pharmacol. 342: 141-145.
5. Emala, C.W., Clancy, J., and Hirshman, C.A. 1997. Glucocorticoid treatment decreases muscarinic receptor expression in canine airway smooth muscle. Am. J. Physiol. 272:L745-L751.
6. Ewart, S.L., Mitzner, W., DiSilvestre, D.A., Meyers, D.A., and Levitt, R.C. 1996. Airway hyperresponsiveness to acetylcholine: Segregation analysis and evidence for linkage to murine chromosome 6. Am. J. Respir. Cell Mol. Biol. 14:487-495.
7. 2 muscarinic receptors in the lungs. Life Sci. 52: 529-536.
8. Garassen, J., Van Loveren, H., Gierveld, C.M., Van Der Vliet, H., and Nijkamp, F.P. 1993. Functional characterization of muscarinic receptors in murine airways. Br. J. Pharmacol. 109: 53-60.
9. Gleich, G.J., Jacoby, D.B., and Fryer, A.D. 1995. Eosinophil-assosiated inflammation in bronchial asthma: A connection to the nervous system. Int. Arch. Allergy Immunol. 107: 205-207.
10. 2 muscarinic receptor. TIPS 19: 322-327.
11. Haddad, E.B., Landry, Y., and Gies, J.P. 1991. Muscarinic receptor subtypes in guinea pig airways. Am. J. Physiol. 261: L327-L333.
12. Haddad, E.B., Mak, J.C.W., Belvisi, M.G., Nishikawa, M., Rousell, J., and Barnes, P.J. 1996. Muscarinic and ß-adrenergic receptor expression in peripheral lung from normal and asthmatic patients. Am. J. Physiol. 270: L947-L953.
13. 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 345: 1213-1214.
14. 2 adrenoceptor polymorphisms: Are they clinically important? Thorax. 51: 351-353.
15. 2 muscarinic receptors in airway smooth muscle contraction. Life Sci. 64: 443-448.
16. Kadota, H., Kuwahara, M., Nishibata, R., Mikami, H., and Tsubone, H. 2001. Effect of acetylcholinesterase activity on pathogenesis of airway hyperresponsiveness in guinea pigs. Exp. Anim. 50: 91-95.
17. Koga, Y., Satoh, S., Sodeyama, N., Hashimoto, Y., Yanagisawa, T., and Hirshman, C.A. 1992. Role of acetylcholinesterase in airway epithelium-mediated inhibition of acetylcholine-induced contraction of guinea-pig isolated trachea. Eur. J. Pharmacol. 220: 141-146.
18. Kubo, T., Maeda, A., Sugimoto, K., Akiba, I., Mikami, A., Takahashi, H., Haga, T., Haga, K., Ichiyama, A., Kangawa, K., Matsuo, H., Hirose, T., and Numa, S. 1986. Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence. FEBS Lett. 209: 367-372.
19. Levitt, R.C. and Mitzner, W. 1989. Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine. J. Appl. Physiol. 67: 1125-1132.
20. Levitt, R.C. and Mitzner, W. 1988. Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice. FASEB J. 2: 2605-2608.
21. Mak, J.C.W., Baraniuk, J.N., and Barnes, P.J. 1992. Localization of muscarinic receptor subtype mRNAs in human lung. Am. J. Respir. Cell Mol. Biol. 4: 344-348.
22. Mikami, H., Inoue, A., Nishibata, R., Namura, S., Ino, T., and Kawamoto, Y. 1988. Reaction of various experimental animals to exposure to acetylcholine or histamine, and morphological observations of bronchial smooth muscle. Exp. Anim. 37: 269-275.
23. Mikami, H., Nishibata, R., Kawamoto, Y., and Ino, T. 1991. Selective breeding of two lines of guinea pigs differing in bronchial sensitivity to acetylcholine and histamine exposure. Exp. Anim. 45: 195-202.
24. Mikami, H., Nishibata, R., Osaki, K., Numazawa, T., Kawamoto, Y., and Ino, T. 1991. Characteristics of two line of guinea pigs (BHS and BHR) differing in bronchial sensitivity to acetylcholine and histamine exposure. Exp. Anim. 40: 453-460.
25. Minette, P.A., Lammers, J., Dixon, C.M.S., McCusker, M.T., and Barnes, P.J. 1989. A muscarinic agonist inhibits reflex bronchoconstriction in normal but in asthmatic subjects. J. Appl. Physiol. 67: 2461-2465.
26. Patel, H.J., Barnes, P.J., Takahashi, T., Tadjkarimi, S., Yacoub, M.H., and Belvisi, M.G. 1995. Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Am. J. Respir. Crit. Care Med. 152: 872-878.
27. Ramnarine, S.I., Haddad, E.B., Khawaja, A.M., Mak, J.C.W., and Rogers, D.F. 1996. On muscarinic control of neurogenic mucus secretion in ferret trachea. J. Physiol. 494: 577-586.
28. Schaefer, O.P., Ethier, M.F., and Madison, J.M. 1995. Muscarinic regulation of cyclic AMP in bovine trachealis cells. Am. J. Respir. Cell Mol. Biol. 13: 217-226.
29. 2 receptors after the early allergic reaction: Possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs. Br. J. Pharmacol. 114: 881-887.
30. Tsubone, H., Sekizawa, S., Maeda, M., Kuwahara, M., Birumachi, J., Sugano, S., Nishibata, R., and Mikami, H. 1997. Bradykinin-induced airway contraction in two lines of guinea pigs with congenitally different airway sensitivity. J. Vet. Med. Sci. 59:613-615.
31. 2-adrenergic receptor in nocturnal and nonnocturnal asthma: Evidence that Gly16 correlates with the nocturnal phenotype. J. Clin. Invest. 95: 1635-1641.
32. 3H] acetylcholine release from the isolated guinea-pig trachea. Naunyn Schmiedebergs Arch. Pharmacol. 342: 387-393.
33. Yagi, Y., Kuwahara, M., Maeda, M., Kadota, H., Saegusa, S., Birumachi, J., Sugano, S., Nishibata, R., Mikami, H., and Tsubone, H. 1998. Airway responsiveness to acetylcholine in congenitally bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs in vivo and in vitro. Exp. Anim. 47: 173-181.