Pattern formation during C. elegans vulval induction

Current Topics in Developmental Biology

Volumn 51, Issue , 2001, Pages 189-220

  Wang, Minqin ^a   Sternberg, Paul W ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; LET 60 PROTEIN, C ELEGANS; LET-60 PROTEIN, C ELEGANS; RAS PROTEIN;

ANIMAL; CAENORHABDITIS ELEGANS; CYTOLOGY; EMBRYO INDUCTION; EVOLUTION; FEMALE; FORECASTING; METABOLISM; MORPHOGENESIS; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; VULVA;

ANIMALS; BODY PATTERNING; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; EMBRYONIC INDUCTION; EVOLUTION; FEMALE; FORECASTING; RAS PROTEINS; SIGNAL TRANSDUCTION; STEM CELLS; VULVA;

EID: 0035219986     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0070-2153(01)51006-6     Document Type: Review

References (131)

1. V Ambros Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulval precursor cells Development 126 1999 1947 1956
2. V Ambros H.R Horvitz Heterochronic mutants of the nematode Caenorhabditis elegans Science 226 1984 409 416
3. V Ambros H.R Horvitz The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events Genes Dev. 1 1987 398 414
4. R.V Aroian P.W Sternberg Multiple functions of let-23 , a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction Genetics 128 1991 251 267
5. R.V Aroian M Koga J.E Mendel Y Ohshima P.W Sternberg The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily Nature 348 1990 693 699
6. G.J Beitel Genetic and molecular analysis of let-60 ras, lin-1 and lin-9 : genes that function in C. elegans vulval induction Ph.D. thesis 1994 Massachusetts Institute of Technology Cambridge, Massachusetts
7. G.J Beitel S.G Clark H.R Horvitz Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction Nature 348 1990 503 509
8. G.J Beitel S Tuck I Greenwald H.R Horvitz The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch in the vulval induction pathway Genes Dev. 9 1995 3149 3162
9. K Brunschwig C Wittmann R Schnabel T.R Bürglin H Tobler F Müller Anterior organization of the Caenorhabditis elegans embryo by the labial -like Hox gene ceh-13 Development 126 1999 1537 1546
10. R.D Burdine C.S Branda M.J Stern EGF-17(FGF) expression coordinates the attraction of the migration sex myoblasts with vulval induction in C. elegans Development 125 1998 1083 1093
11. H.M Chamberlin P.W Sternberg The -3/let-23 pathway mediates inductive signaling during male spicule development in norhabditis elegans Development 120 1994 2713 2721
12. C Chang N.A Hopper P.W Sternberg C. elegans SOS-1 is required for multiple RAS-dependent events and cooperates with a SOS-1-independent pathway during vulval induction Embo J. 19 2000 3283 3293
13. T.R Clandinin W.S Katz P.W Sternberg Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal Dev. Biol. 182 1997 150 161
14. S.G Clark M.J Stern H.R Horvitz C. elegans cell-signaling gene sem-5 encodes a protein with SH2 and SH3 domains Nature 356 1992 340 344
15. S.G Clark M.J Stern H.R Horvitz Genes involved in two Caenorhabditis elegans cell-signaling pathways Cold Spring Harb. Symp. Quant. Biol. 57 1992 363 373
16. S.G Clark A.D Chisholm H.R Horvitz Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39 Cell 74 1993 43 55
17. S.G Clark X Lu H.R Horvitz The Caenorhabditis elegans locus lin-15 , a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins Genetics 137 1994 987 997
18. J Cooke J.C Smith Measurement of developmental time by cells of early embryos Cell 60 1990 891 894
19. B.A Edgar P.H O'Farrel The three postblastoderm cell cycles of Drosophila embryo-genesis are regulated in G2 by string Cell 62 1990 469 480
20. D.M Eisenmann S.K Kim Signal transduction and cell fate specification during Caenorhabditis elegans vulval development Curr. Opin. Genet. Dev. 4 1994 508 516
21. D.M Eisenmann J.N Maloof J.S Simske C Kenyon S.K Kim The β-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development Development 125 1998 3667 3680
22. A Eizinger R.J Sommer The homeotic gene lin-39 and the evolution of nematode epidermal cell fates Science 278 1997 452 455
23. S Euling V Ambros Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulval precursor cells Cell 84 1996 667 676
24. S Euling V Ambros Reversal of cell fate determination in Caenorhabditis elegans vulval development Development 122 1996 2507 2515
25. M.-A Félix P.W Sternberg Two nested gonadal inductions of the vulva in nematodes Development 124 1997 253 259
26. E.L Ferguson H.R Horvitz Identification and genetic characterization of 22 genes that affect the vulval lineages of the nematode Caenorhabditis elegans Genetics 110 1985 17 72
27. E.L Ferguson H.R Horvitz The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways Genetics 123 1989 109 121
28. E.L Ferguson P.W Sternberg H.R Horvitz A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans Nature 326 1987 259 267
29. W Fixsen P.W Sternberg H Ellis H.R Horvitz Genes that affect cell fates during the development of Caenorhabditis elegans Cold Spring Harbor Symp. Quant. Biol. 50 1985 99 104
30. M Freeman Cell determination strategies in the Drosophila eye Development 124 1997 261 270
31. R.H Gomer R.A Firtel Cell-autonomous determination of cell-type choice in Dictyostelium development by cell-cycle phase Science 237 1987 758 762
32. B Grant I Greenwald The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1 , encodes a predicted extracellular protein Genetics 143 1996 237 247
33. I Greenwald Development of the vulva D Riddle T Blumenthal B Meyer J Priess C. elegans II 1997 Cold Spring Harbor Laboratory Press New York 519 541
34. I Greenwald G Seydoux Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans Nature 346 1990 197 199
35. I.S Greenwald P.W Sternberg H.R Horvitz The lin-12 locus specifies cell fates in Caenorhabditis elegans Cell 34 1983 435 444
36. T Gu S Orita M Han Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction Mol. Cell. Biol. 18 1998 4556 4564
37. J.B Gurdon A Mitchell D Mahony Direct and continuous assessment by cells of their position in a morphogen gradient Nature 376 1985 520 521
38. M.J Gutch A.J Flint J Keller N.K Tonks M.O Hengartner The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development Genes Dev. 12 1998 571 585
39. A Hajnal C.W Whitfield S.K Kim Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase Genes Dev. 11 1997 2715 2728
40. M Han P.W Sternberg let-60 , a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein Cell 63 1990 921 931
41. M Han R Aroian P.W Sternberg The let-60 locus controls the switch between vulval and non-vulval cell types in C. elegans Genetics 126 1990 899 913
42. M Han A Golden Y Han P.W Sternberg C. elegans lin-45 raf gene participates in let-60 ras -mediated vulval differentiation Nature 363 1993 133 140
43. W.A Harris V Hartenstein Neuronal induction without cell division in Xenopus embryos Neuron 6 1991 499 515
44. V Hartentein J.W Posakony Sensillum development in the absence of cell division: the sensillum phenotype of the Drosophila mutant string Dev. Biol. 138 1990 147 158
45. E.M Hedgecock R.K Herman The ncl-1 gene and genetic mosaics of Caenorhabditis elegans Genetics 141 1995 989 1006
46. R.K Herman E.M Hedgecock Limitations of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis Nature 348 1990 169 171
47. R.J Hill P.W Sternberg The gene lin-3 encodes an inductive signal for vulval development for C. elegans Nature 358 1992 470 476
48. Y Hong R Roy V Ambros Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans Development 125 1999 3585 3597
49. N.A Hopper J Lee P.W Sternberg ARK-1 inhibits EGFR signaling in C. elegans Molec. Cell 6 2000 65 75
50. H.R Horvitz P.W Sternberg Multiple intercellular signaling systems control the development of the Caenorhabditis elegans vulva Nature 351 1991 535 541
51. H.R Horvitz J.E Sulston Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans Genetics 96 1980 435 454
52. R Hoskins A.F Hajnal S Harp S.K Kim The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins Development 122 1996 97 111
53. J Hsieh J Liu S.A Kostas C Chang P.W Sternberg A Fire The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans Genes Dev. 13 1999 2958 2970
54. L.S Huang P Tzou P.W Sternberg The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development Mol. Biol. Cell 5 1994 395 412
55. E.J.A Hubbard G Wu J Kitajewski I Greenwald sel-10 , a negative regulator of lin-12 activity in Caenorhabditis elegans , encodes a member of the CDC4 family of proteins Genes Dev. 11 1997 3182 3193
56. L.I Jiang P.W Sternberg Interaction of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans Development 125 1998 2337 2347
57. G.D Jongeward T.R Clandinin P.W Sternberg sli-1 , a negative regulator of let-23 -mediated signaling in C. elegans Genetics 139 1995 1553 1566
58. S.M Kaech C.W Whitfield S.K Kim The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells Cell 94 1998 761 771
59. W.S Katz R.J Hill T.R Clandinin P.W Sternberg Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates Cell 82 1995 297 307
60. W.S Katz G.M Lesa D Yannoukakos T.R Clandinin J Schlessinger P.W Sternberg A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans Epidermal Growth Receptor homolog Mol. Cell. Biol. 16 1996 529 537
61. J Kimble Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans Dev. Biol. 87 1981 286 300
62. J Kimble P Simpson The LIN-12/Notch signaling pathway and its regulation Ann. Rev. Cell Dev. Biol. 13 1997 333 361
63. R.W King R.J Deshaies J.-M Peteres M.W Kirschner How proteolysis drives the cell cycle Science 274 1996 1652 1658
64. E.T Kipreos L.E Lander J.P Wing W.W He E.M Hedgecock cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family Cell 85 1996 829 839
65. M Koga Y Ohshima Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans Development 121 1995 2655 2666
66. K Kornfeld Vulval development in Caenorhabditis elegans Trends Genet. 13 1997 55 61
67. K Kornfeld K.-L Guan H.R Horvitz The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK Genes Dev. 9 1995 756 768
68. K Kornfeld D.B Hom H.R Horvitz The ksr-1 gene encodes a novel protein kinase involved in ras -mediated signaling in Caenorhabditis elegans Cell 83 1995 903 913
69. M.R Lackner K Kornfeld L.M Miller H.R Horvitz S.K Kim A MAP kinase homologue, mpk-1 , is involved in ras mediated induction of vulval cell fates in Caenorhabditis elegans Genes Dev. 8 1994 160 173
70. J Lee G.D Jongeward P.W Sternberg unc-101 , a gene required for many aspects of Caenorhabditis elegans development and behavior, encoded a clathrin-associated protein Genes Dev. 8 1994 60 73
71. D Levitan I Greenwald Facilitation of lin-12 -mediated signaling by sel-12 , a Caenorhabditis elegans S182 Alzheimer's disease gene Nature 377 1995 351 354
72. D Levitan I Greenwald LIN-12 protein expression and localization during vulval development in C. elegans Development 125 1998 3101 3109
73. D Levitan I Greenwald Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans Development 125 1998 3599 3606
74. X Lu H.R Horvitz lin-35 and lin-53 , two genes that antaganize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48 Cell 95 1998 981 991
75. J.N Maloof C Kenyon The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling Development 125 1998 181 190
76. S.K McConnell C.E Kaznowski Cell cycle dependence of laminar determination in developing neocortex Science 254 1991 282 285
77. L.M Miller M.E Gallegos B.A Morisseau S.K Kim lin-31 , a Caenorhabditis elegans HNF- 3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development Genes Dev. 7 1993 933 947
78. L.M Miller D.A Waring S.K Kim Mosaic analysis using a ncl-1 (+) extrachromosomal array reveals that lin-31 acts in the Pn.p cells during Caenorhabditis elegans vulval development Genetics 143 1996 1181 1191
79. E.G Moss R.C Lee V Ambros Control of developmental timing in C. elegans by the cold chock domain protein LIN-28 and its regulation by the lin-4 RNA Cell 88 1997 637 646
80. A.P Newman J.G White P.W Sternberg Morphogenesis of the C. elegans hermaphrodite uterus Development 122 1996 3617 3626
81. D Pan G.M Rubin Kuzbaninian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis Cell 90 1997 271 280
82. G.D Plowman S Sundarsanam J Bingham D Whyte T Hunter The protein kinases of Caenorhabditis elegans : a model for signal transduction in multicellular organisms Proc. Natl. Acad. Sci. USA 96 1999 13603 13610
83. M.C Raff E.R Abney J Fok-Seang Reconstitution of a developmental clock in vitro: a critical role for astrocytes in the timing of oligodendrocyte differentiation Cell 42 1985 61 69
84. W.J Ray M Yao P Nowotny J Mumm W Zhang J.Y Wu R Kopan A.M Goate Evidence for physical interaction between presenilin and Notch Proc. Natl. Acad. Sci. USA 96 1999 3263 3268
85. S.J Salser C Kenyon Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration Nature 355 1992 255 258
86. S.J Salser C.M Loer C Kenyon Multiple HOM-C gene interactions specify cell fates in the nematode central nervous system Genes Dev. 7 1993 1714 1724
87. H Sawa L Lobel H.R Horvitz The Caenorhabditis elegans gene lin-17 , which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila Frizzled protein Genes Dev. 10 1996 2189 2197
88. R Sharma-Kishore J.G White E Southgate B Podbilewicz Formation of the vulva in Caenorhabditis elegans : a paradigm for organogenesis Development 126 1999 691 699
89. Y Shi C Mello A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans Genes Dev. 12 1998 943 955
90. D.S Sieburth Q Sun M Han SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans Cell 94 1998 119 130
91. D.S Sieburth M Sundaram R.M Howard M Han A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction Genes Dev. 13 1999 2562 2569
92. J.S Simske S.K Kim Sequential signaling during Caenorhabditis elegans vulval induction Nature 375 1995 142 146
93. J.S Simske S.M Kaech S.A Harp S.K Kim LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction Cell 85 1996 195 204
94. N Singh M Han sur-2 , a novel gene, functions late in the let-60 ras -mediated signaling pathway during Caenorhabditis elegans vulval induction Genes Dev. 9 1995 2251 2265
95. F Solari J Ahringer NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans Curr. Biol. 10 2000 223 226
96. F Solari A Bateman J Ahringer The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning Development 126 1998 2483 2494
97. R.J Sommer Evolutionary changes of developmental mechanisms in the absence of cell lineage alterations during vulval formation in the Diplogastridae (Nematoda) Development 124 1997 243 251
98. R.J Sommer P.W Sternberg Changes of induction and competence during the evolution of vulval development in nematodes Science 265 1994 114 118
99. R.J Sommer P.W Sternberg Apoptosis and change of competence limit the size of the vulva equivalence group in Pristionchus pacificus : a genetic analysis Current Biology 6 1996 52 59
100. R.J Sommer A Eizinger K.-Z Lee B Jungblut A Bubeck I Schlak The Pristionchus HOX gene Ppa-lin-39 inibits programmed cell death to specify the vulva equivalence group and is not required during vulval induction Development 125 1998 3865 3873
101. M.J Stern D.L DeVore Extending and connecting signaling pathways in C. elegans Dev. Biol. 166 1994 443 459
102. P.W Sternberg Lateral inhibition during vulval induction in Caenorhabditis-elegans Nature 335 1988 551 554
103. P.W Sternberg M Han Genetics of RAS signaling in C. elegans Trends Genet. 14 1998 452 466
104. P.W Sternberg H.R Horvitz Pattern formation during vulval induction in C. elegans Cell 44 1986 761 772
105. P.W Sternberg H.R Horvitz lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions Dev. Biol. 130 1988 67 73
106. P.W Sternberg H.R Horvitz The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans Cell 58 1989 679 693
107. P.W Sternberg C.H Yoon J Lee G.D Jongeward P.S Kayne W.S Katz G Lesa J Liu A Golden L.S Huang H.M Chamberlin Molecular genetics of proto-oncogenes and candidate tumor suppressors in Caenorhabditis elegans Cold Spring Harb. Symp. Quant. Biol. 59 1994 155 163
108. J.E Sulston H.R Horvitz Postembryonic cell lineages of the nematode Caenorhabditis elegans Dev. Biol. 56 1977 110 156
109. J.E Sulston H.R Horvitz Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans Dev. Biol. 82 1981 41 55
110. J.E Sulston J.G White Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans Dev. Biol. 78 1980 577 597
111. M Sundaram I Greenwald Suppressor of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans Genetics 135 1993 765 783
112. M Sundaram M Han The Caenorhabditis elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction Cell 83 1995 889 901
113. M Sundaram M Han Control and integration of cell signaling pathways during C. elegans vulval development Bioessays 18 1996 473 480
114. P.B Tan M.R Lackner S.K Kim MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction Cell 93 1998 569 580
115. F.E Tax J.H Thomas E.L Ferguson H.R Horvitz Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans Genetics 147 1997 1675 1695
116. J.H Thomas H.R Horvitz The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway Development 126 1999 3449 3459
117. J.H Thomas M.J Stern H.R Horvitz Cell interactions coordinate the development of the C. elegans egg-laying system Cell 62 1990 1041 1052
118. A Tomlinson G Struhl Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye Development 126 1999 5725 5738
119. S Tuck I Greenwald lin-25 , a gene required in vulval induction in Caenorhabditis elegans Genes Dev. 9 1995 341 357
120. A.J.M Walhout R Sordella X Lu J.L Hartley G.F Temple M.A Brasch N Thierry-Mieg M Vidal Protein interaction mapping in C. elegans using proteins involved in vulval development Science 287 2000 116 122
121. M Wang P.W Sternberg Competence and commitment of Caenorhabditis elegans vulval precursor cells Dev. Biol. 212 1999 12 24
122. B.B Wang M.M Muller-Immergluck J Austin N.T Robinson A Chisholm C Kenyon A homeotic gene cluster patterns the anteroposterior body axis of C. elegans Cell 74 1993 29 42
123. C Wen M.M Metzstein I Greenwald SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signaling Development 124 1997 4759 4767
124. C.W Whitfield C Benard T Barnes S Hekimi S.K Kim Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10 Mol. Biol. Cell 10 1999 2087 2100
125. B Wightman T.R Burglin J Gatto P Arasu G Ruvkun Negative regulatory sequences in the lin-14 3′-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development Genes Dev. 5 1991 1813 1824
126. C Wittmann O Bossinger B Goldstein M Fleischmann R Kohler K Brunschwig H Tobler F Müller The expression of the C. elegans labial-like Hox gene ceh-13 during early embryogenesis relies on cell fate and on anteroposterior cell polarity Development 124 1997 4193 4200
127. Y Wu M Han Suppression of activated Let-60 Ras defines a role of Caenorhabditis elegans sur-1 MAP kinase in vulval differentiation Genes Dev. 8 1994 147 159
128. Y Wu M Han K.-L Guan MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events Genes Dev. 9 1995 742 755
129. G Wu E.J.A Hubbard J.K Kitajewski I Greenwald Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin Proc. Natl. Acad. Sci. USA 95 1998 15787 15791
130. J Yochem K Weston I Greenwald The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch Nature 335 1988 547 550
131. C.H Yoon J Lee G.D Jongeward P.W Sternberg Similarity of sli-1 , a regulator of vulval development in C. elegans , to the mammalian proto-oncogene c-cbl Science 269 1995 1102 1105