Effect of graded hypoxia on the rat hepatic tissue oxygenation and energy metabolism monitored by near-infrared and 31P nuclear magnetic resonance spectroscopy

FASEB Journal

Volumn 15, Issue 14, 2001, Pages 2642-2648

  Seifalian, A M ^a   El Desoky, E H ^a   Delpy, D T ^a   Davidson, B R ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

nucleoside triphosphate; Liver hypoxia; NIMR

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; DEOXYHEMOGLOBIN; NUCLEOSIDE TRIPHOSPHATE; OXYGEN; OXYHEMOGLOBIN;

ARTICLE; CELL HYPOXIA; CELL PH; ENERGY METABOLISM; INFRARED SPECTROSCOPY; LIVER INJURY; LIVER ISCHEMIA; LIVER METABOLISM; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; TISSUE OXYGENATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANOXIA; ELECTRON TRANSPORT COMPLEX IV; ENERGY METABOLISM; HEMOGLOBINS; HYDROGEN-ION CONCENTRATION; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDES; OXYGEN; OXYHEMOGLOBINS; PHOSPHATES; PHOSPHORIC ACID ESTERS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, INFRARED;

ANIMALIA;

EID: 0035214586     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0308com     Document Type: Article

References (47)

1. New simple models to evaluate zone-specific damage due to hipoxia in the perfused rat liver: Time course and effect of nutritional state
2. Effect of short lasting hypoxia on the metabolic function of the perfused pig liver. Comparison of ischaemic and hypoxaemic hypoxia
3. Reliable indices for the determination of viability of grafted liver immediately after orthotopic transplantation: Bile flow rate and cellular adenosine triphosphate level
4. Restoration of ATP contents in the transplanted liver closely relates to graft viability in dogs
5. Determination of adenosine-5-triphosphate with hexokinase and glucose-6-phosphate dehydrogenase
6. Changes in cellular levels of ATP and its catabolites in ischaemic rat liver
7. 31P NMR
8. Principles of multiwavelength near infrared spectroscopy for assessing oxidative metabolism
9. Structure and function of cytochrome c oxidase
10. Halothane induced lipid peroxidation and glucose 6 phosphatase inactivation in microsomes under hypoxic conditions
11. In vivo near-infrared spectroscopy
12. Metabolism of carbohydrates and formation of adenosine triphosphate
13. The mitochondrial permeability transition pore and its role in cell death
14. Energy-dependent redox state of heme a + a3 and copper of cytochrome oxidase in perfused rat brain in situ
15. Liver adenosine triphosphate (ATP) in hypoxia and hemorrhagic shock
16. Phosphorus-31 nuclear-magnetic-resonance study of phosphorylated metabolites compartmentation, intracellular pH and phosphorylation state during normoxia, hypoxia and ethanol perfusion, in the perfused rat liver
17. 31P-NMR studies of perfused mouse liver during nitrogen hypoxia
18. Changes in tissue oxygenation of the porcine liver measured by near infrared spectroscopy
19. Effect of graded hypoxia on hepatic tissue oxygenation measured by near infrared spectroscopy
20. Assessment of hepatic ischaemia reperfusion injury by measuring intracellular tissue oxygenation using near infrared spectroscopy
21. 31P NMR
22. The metabolism of purine and pyrimidine nucleotides during insulin-induced hypoglycemia and recovery
23. 13C resonances
24. 31P-NMR spectra using the surface-coil technique
25. Tissue metabolism studied in vivo by nuclear magnetic resonance
26. 31P-MRS in the rat
27. 31P-NMR spectroscopy
28. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies
29. The pathogenesis of irreversible cell injury in ischaemia
30. Defence strategies against hypoxia and hypothermia
31. The effects of anoxia on cytosolic free calcium, calcium fluxes and cellular ATP levels in cultured kidney cells
32. Sodium-mediated cell swelling is associated with irreversible damage in isolated hepatocytes exposed to hypoxia or mitochondrial toxins
33. Oxygen supply and uptake in the liver and the intestine
34. Liver hemodynamics and liver function in cats during graded hypoxic hypoxemia
35. Measurement of hepatic tissue hypoxia using near infrared spectroscopy: Comparison with hepatic vein oxygen partial pressure
36. Systemic hypoxia and hyperoxia, and liver blood flow and oxygen consumption in the greyhound. Synthesis of prostanoids and cyclic nucleotides by phagocytosing rat Kupffer cells
37. Near-infrared spectroscopy of the brain: Relevance to cytochrome oxidase bioenergetics
38. Mitochondrial function under hypoxic conditions: The steady states of cytochrome aa3 and their relation to mitochondrial energy states
39. Differences in the altered energy metabolism of hemorrhagic shock and hypoxemia
40. The oxygen dependence of cellular energy metabolism
41. Quantitative dependence of mitochondrial oxidative phosphorylation on oxygen concentration: A mathematical model
42. Intracellular oxygen supply during hypoxia
43. An experimental evaluation of the order of revascularization after interrupting hepatic afferent blood flow
44. 31P magnetic resonance spectroscopy study
45. Respiratory chains
46. Effect of oxygen tension on cellular energetics